A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes

Autor: Joanna Hui Juan Tan, Zhihui Li, Mar Gonzalez Porta, Ramesh Rajaby, Weng Khong Lim, Ye An Tan, Rodrigo Toro Jimenez, Renyi Teo, Maxime Hebrard, Jack Ling Ow, Shimin Ang, Justin Jeyakani, Yap Seng Chong, Tock Han Lim, Liuh Ling Goh, Yih Chung Tham, Khai Pang Leong, Calvin Woon Loong Chin, SG10K_Health Consortium, Sonia Davila, Neerja Karnani, Ching-Yu Cheng, John Chambers, E. Shyong Tai, Jianjun Liu, Xueling Sim, Wing Kin Sung, Shyam Prabhakar, Patrick Tan, Nicolas Bertin

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Structural variants (SVs) are significant contributors to inter-individual genetic variation associated with traits and diseases. Current SV studies using whole-genome sequencing (WGS) have a largely Eurocentric composition, with little know

Externí odkaz: https://doaj.org/article/bb56de9b54524700a6c80797234f227e

The evaluation of goal-directed activities to promote well-being and health in heart failure: EUROIA scale

Autor: Robert P. Nolan, Fatima Syed, Nicolette Stogios, Robert Maunder, Sanjeev Sockalingam, E. Shyong Tai, Mark Cobain, Rachel G. Peiris, Ella Huszti

Publikováno v: Journal of Patient-Reported Outcomes, Vol 8, Iss 1, Pp 1-13 (2024)

Abstract Background The EvalUation of goal-diRected activities to prOmote well-beIng and heAlth (EUROIA) scale is a novel patient-reported measure that was administered to individuals with chronic heart failure (CHF). It assesses goal-directed activi

Externí odkaz: https://doaj.org/article/a780e2662aaf42a681639e09fee05525

X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements

Autor: Markus Scholz, Katrin Horn, Janne Pott, Matthias Wuttke, Andreas Kühnapfel, M. Kamal Nasr, Holger Kirsten, Yong Li, Anselm Hoppmann, Mathias Gorski, Sahar Ghasemi, Man Li, Adrienne Tin, Jin-Fang Chai, Massimiliano Cocca, Judy Wang, Teresa Nutile, Masato Akiyama, Bjørn Olav Åsvold, Nisha Bansal, Mary L. Biggs, Thibaud Boutin, Hermann Brenner, Ben Brumpton, Ralph Burkhardt, Jianwen Cai, Archie Campbell, Harry Campbell, John Chalmers, Daniel I. Chasman, Miao Ling Chee, Miao Li Chee, Xu Chen, Ching-Yu Cheng, Renata Cifkova, Martha Daviglus, Graciela Delgado, Katalin Dittrich, Todd L. Edwards, Karlhans Endlich, J. Michael Gaziano, Ayush Giri, Franco Giulianini, Scott D. Gordon, Daniel F. Gudbjartsson, Stein Hallan, Pavel Hamet, Catharina A. Hartman, Caroline Hayward, Iris M. Heid, Jacklyn N. Hellwege, Bernd Holleczek, Hilma Holm, Nina Hutri-Kähönen, Kristian Hveem, Berend Isermann, Jost B. Jonas, Peter K. Joshi, Yoichiro Kamatani, Masahiro Kanai, Mika Kastarinen, Chiea Chuen Khor, Wieland Kiess, Marcus E. Kleber, Antje Körner, Peter Kovacs, Alena Krajcoviechova, Holly Kramer, Bernhard K. Krämer, Mikko Kuokkanen, Mika Kähönen, Leslie A. Lange, James P. Lash, Terho Lehtimäki, Hengtong Li, Bridget M. Lin, Jianjun Liu, Markus Loeffler, Leo-Pekka Lyytikäinen, Patrik K. E. Magnusson, Nicholas G. Martin, Koichi Matsuda, Yuri Milaneschi, Pashupati P. Mishra, Nina Mononen, Grant W. Montgomery, Dennis O. Mook-Kanamori, Josyf C. Mychaleckyj, Winfried März, Matthias Nauck, Kjell Nikus, Ilja M. Nolte, Raymond Noordam, Yukinori Okada, Isleifur Olafsson, Albertine J. Oldehinkel, Brenda W. J. H. Penninx, Markus Perola, Nicola Pirastu, Ozren Polasek, David J. Porteous, Tanja Poulain, Bruce M. Psaty, Ton J. Rabelink, Laura M. Raffield, Olli T. Raitakari, Humaira Rasheed, Dermot F. Reilly, Kenneth M. Rice, Anne Richmond, Paul M. Ridker, Jerome I. Rotter, Igor Rudan, Charumathi Sabanayagam, Veikko Salomaa, Neil Schneiderman, Ben Schöttker, Mario Sims, Harold Snieder, Klaus J. Stark, Kari Stefansson, Hannah Stocker, Michael Stumvoll, Patrick Sulem, Gardar Sveinbjornsson, Per O. Svensson, E-Shyong Tai, Kent D. Taylor, Bamidele O. Tayo, Andrej Teren, Yih-Chung Tham, Joachim Thiery, Chris H. L. Thio, Laurent F. Thomas, Johanne Tremblay, Anke Tönjes, Peter J. van der Most, Veronique Vitart, Uwe Völker, Ya Xing Wang, Chaolong Wang, Wen Bin Wei, John B. Whitfield, Sarah H. Wild, James F. Wilson, Thomas W. Winkler, Tien-Yin Wong, Mark Woodward, Xueling Sim, Audrey Y. Chu, Mary F. Feitosa, Unnur Thorsteinsdottir, Adriana M. Hung, Alexander Teumer, Nora Franceschini, Afshin Parsa, Anna Köttgen, Pascal Schlosser, Cristian Pattaro

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-relat

Externí odkaz: https://doaj.org/article/268d127148904565be810f5bb7b9bb96

Personalised care and support planning in Singapore: qualitative interviews with people living with diabetes

Autor: Monica Lazarus, Tong Wei Yew, Wee Hian Tan, Kavita Venkataraman, Jose Maria Valderas, Doris Yee Ling Young, E Shyong Tai, Victor Weng Keong Loh

Publikováno v: BJGP Open, Vol 8, Iss 1 (2024)

Background: Personalised care and support planning (CSP) is a person-centred approach for the care of people living with long-term conditions. Patient Activation through Community Empowerment/Engagement for Diabetes Management (PACE-D) adapts the Yea

Externí odkaz: https://doaj.org/article/b7d2991317524b248d41af3ecde2edea

Patient perspectives of diabetes care in primary care networks in Singapore: a mixed-methods study

Autor: Lay Hoon Goh, Anna Szücs, Chiew Jiat Rosalind Siah, Monica A Lazarus, E Shyong Tai, Jose M Valderas, Doris Yee Ling Young

Publikováno v: BMC Health Services Research, Vol 23, Iss 1, Pp 1-14 (2023)

Abstract Background Type 2 diabetes (T2D) remains an important chronic condition worldwide requiring integrated patient-centred care as advocated by the Chronic Care Model (CCM). The Primary Care Networks (PCNs) in Singapore organise general practiti

Externí odkaz: https://doaj.org/article/0406c812d0ab4d0792dacbc3401a59df