Zobrazeno 1 - 10
of 259
pro vyhledávání: '"E. von Angerer"'
Publikováno v:
Journal of Medicinal Chemistry. 41:4965-4972
The aim of this study was the identification of the essential structural elements in the 12-formyl-5,6-dihydroindolo[2, 1-a]isoquinoline system required for the inhibition of tubulin polymerization which is understood to be the predominant mode of ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b613ad21645e00c8b5cf149e97fe87
https://doi.org/10.1021/jm980228l
https://doi.org/10.1021/jm980228l
Autor:
E. von Angerer, C. Biberger
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 64:277-285
In the 2-phenylindole system, the side chain at the nitrogen atom dominates the endocrine profile both in respect to the reduction of estrogenic action and the increase of antiestrogenic potency. In previous papers we reported on 2-phenylindoles with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b995faa729b15f250508ffc57d424d7
https://doi.org/10.1016/s0960-0760(97)00197-0
https://doi.org/10.1016/s0960-0760(97)00197-0
Publikováno v:
Journal of Radiosurgery. 1:51-56
Gamma-knife radiosurgery is one of the only means of treating otherwise inoperable intracranial neoplasia. At present the mechanism by which single-dose γ-radiation reduces tumor bulk is unknown. Using the human mammary cell line MCF-7 to represent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e722fc89a235a9733e92af8541f21ae6
https://doi.org/10.1023/b:jora.0000010877.65003.31
https://doi.org/10.1023/b:jora.0000010877.65003.31
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 58:385-393
The proliferation of mammary carcinoma cells can be stimulated by estrogens and various growth factors such as EGF and IGF-I. Steroid hormones and growth factors are understood to exert their effects via different receptors and signal transduction pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b9ddd101c241fd44759c88974861c6
https://doi.org/10.1016/0960-0760(96)00054-4
https://doi.org/10.1016/0960-0760(96)00054-4
Publikováno v:
Annals of the New York Academy of Sciences. 761:176-191
2-Phenylindoles and isosteric structures such as benzo[b]furans and benzo[b]thiophenes were used as estrogen receptor binding moiety for the syntheses of new nonsteroidal antiestrogens. The antiestrogenic potency was considerably enhanced following t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0e0e79c2061558849313b71e945f48
https://doi.org/10.1111/j.1749-6632.1995.tb31378.x
https://doi.org/10.1111/j.1749-6632.1995.tb31378.x
1-carbamoylalkyl-2-phenylindoles: Relationship between side chain structure and estrrogen antagonism
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 49:51-62
The 2-phenylindole system has proved to be a versatile structure for the design of potent antiestrogens, especially when functional groups have been introduced into the alkyl side chain in position 1. In analogy to steroidal structures such as ICI 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489511ea5b0e69526a37724bcc9f3cbb
https://doi.org/10.1016/0960-0760(94)90300-x
https://doi.org/10.1016/0960-0760(94)90300-x
Publikováno v:
Archives of Gynecology and Obstetrics. 254:981-984
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c853dc3d9c4fc066549fb03e4e2e734
https://doi.org/10.1007/bf02266267
https://doi.org/10.1007/bf02266267
Publikováno v:
ChemInform. 22
A number of 1-(omega-aminoalkyl)-5-hydroxy-2-(4-hydroxyphenyl)indoles were synthesized and studied for their binding affinities for the calf uterine estrogen receptor and estrogen antagonistic activities. Highest binding affinities were found with de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc2a1202997d5a3c7f2a94a6eb5122ce
https://doi.org/10.1002/chin.199108188
https://doi.org/10.1002/chin.199108188
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9050650eb133ff68e4ebce4e2f2324e
https://doi.org/10.1002/chin.199316233
https://doi.org/10.1002/chin.199316233
Publikováno v:
ChemInform. 24
Syntheses of 6,7-dihydro-4H-indolones 6 and 10 by a selective Birch reduction of the benzene ring of the indole system are described. The antiestrogen zindoxifene and the 2-phenylindole 2 as well as 6 and 10 were tested for their relative binding aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::739494da446cb4713c960b88a527cc71
https://doi.org/10.1002/chin.199324162
https://doi.org/10.1002/chin.199324162