Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site.

Autor: Vera J E van Vliet, Nhan Huynh, Judith Palà, Ankoor Patel, Alex Singer, Cole Slater, Jacky Chung, Mariska van Huizen, Joan Teyra, Shane Miersch, Gia-Khanh Luu, Wei Ye, Nitin Sharma, Safder S Ganaie, Raquel Russell, Chao Chen, Mindy Maynard, Gaya K Amarasinghe, Brian L Mark, Marjolein Kikkert, Sachdev S Sidhu

Publikováno v: PLoS Pathogens, Vol 18, Iss 12, p e1011065 (2022)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has made it clear that combating coronavirus outbreaks benefits from a combination of vaccines and therapeutics. A promising drug target common to all coronaviruses-including S

Externí odkaz: https://doaj.org/article/ed5803623a7743ac82f5abe2f5dcf89b

Hemoglobinopathy prevention in primary care: a reflection of underdetection and difficulties with accessibility of medical care, a quantitative study

Autor: Margo E. van Vliet, Jean-Louis H. Kerkhoffs, Cornelis L. Harteveld, Elisa J. F. Houwink

Publikováno v: European Journal of Human Genetics, 30(7), 790-794. SPRINGERNATURE

As in most Northern European countries, the prevalence of hemoglobinopathies in The Netherlands is increasing due to migration. Although hemoglobinopathies are severe chronic diseases with few treatment options, timely detection of carriers allows at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc36cad05d5d7bd2ca8933d267754bf
https://doi.org/10.1038/s41431-022-01051-8

Knowledge about the emergency management of dental injuries among field hockey coaches

Autor: Kirsten E. van Vliet, Henk S. Brand, Frank Lobbezoo, Jan de Lange

Publikováno v: van Vliet, K E, Brand, H S, Lobbezoo, F & de Lange, J 2022, ' Knowledge about the emergency management of dental injuries among field hockey coaches ', Dental traumatology, vol. 38, no. 6, pp. 526-531 . https://doi.org/10.1111/edt.12774
Dental traumatology. Blackwell Munksgaard
Dental traumatology, 38(6), 526-531. Blackwell Munksgaard

Background/Aim: Field hockey is frequently associated with oro-dental injuries. In such acute situations, appropriate management of the injury by coaches can contribute to a better clinical outcome and prognosis. Therefore, the aim of this study was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8041bd9ee9f5c4a18d9c097285ff7e8c
https://research.vu.nl/en/publications/54d9509b-9844-416e-8695-13ac0edbf268

The Load-Modulated linearizer: A technique for intermodulation cancellation in PA systems

Autor: Anton N. Atanasov, Wasam R. A. Mukhtar Ahmad, Mark S. Oude Alink, Frank E. Van Vliet

Publikováno v: 2022 IEEE BiCMOS and Compound Semiconductor Integrated Circuits and Technology Symposium (BCICTS), 174-177
STARTPAGE=174;ENDPAGE=177;TITLE=2022 IEEE BiCMOS and Compound Semiconductor Integrated Circuits and Technology Symposium (BCICTS)

—A novel application utilizing the load-modulated balanced amplifier (LMBA) principle to actively absorb individual out-of-band intermodulation components at the output of a power amplifier operating in high compression is presented. The system req

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf01e7f7676303c87e1ea45a559239c3
https://doi.org/10.1109/bcicts53451.2022.10051742

Hemoglobinopathy screening in primary care in the Netherlands: exploring the problems and needs of patients and general practitioners

Autor: Margo E. van Vliet, Jean-Louis H. Kerkhoffs, Cornelis L. Harteveld, Elisa. J. F. Houwink

Publikováno v: European Journal of Human Genetics, 31, 417-423. SPRINGERNATURE

The prevalence of hemoglobinopathies in The Netherlands is increasing due to migration. Hemoglobinopathies are severe hereditary diseases. An informed reproductive choice by at-risk couples, such as pre-implantation diagnosis or termination of affect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e697cf85c6efe11585cb75793cbe20
http://hdl.handle.net/1887/3563774