Zobrazeno 1 - 10
of 119
pro vyhledávání: '"E. Zilkha"'
Autor:
N. G. P. Slater, G. Wetherley-Mein, R. W. Ross Russell, E. Zilkha, L. Symon, P. R. D. Humphrey, T.C. Pearson, J. Marshall, G. H. Boulay
Publikováno v:
Acta Neurologica Scandinavica. 61:201-209
It has been suggested that blood viscosity is involved in the control of cerebral blood flow (CBF) (Thomas et al. 1977a, b, Humphrey et al. 1979). CBF, using the intravenous Xenon133 technique, blood viscosity and haematocrit were measured in 21 pati
Autor:
G. H. Du Boulay, R. W. Ross Russell, L. Symon, G. Wetherley-Mein, E. Zilkha, J. A. Shirley, T.C. Pearson, J. P. H. Wade, John Marshall
Publikováno v:
Acta Neurologica Scandinavica. 61:210-215
The cerebral blood flow is low in primary polycythaemia, and it has been suggested that this is due to the increase in viscosity which accompanies the elevated haematocrit. In the present study cerebral blood flow has been measured by a non-invasive
Publikováno v:
British Journal of Pharmacology. 122:372-378
1 It is generally considered that glutamate-mediated transmission can be altered from a physiological to neurotoxic action when extracellular glutamate levels become excessive subsequent to impaired uptake and/or excessive release. However, high extr
Publikováno v:
Life Sciences. 61:523-535
We have examined how various challenges to brain acid-base homeostasis, resulting in extracellular acidosis, after N -methyl-D-aspartate (NMDA)-evoked depolarizations in vivo . Repeated stimuli were produced by perfusion of 200 μM NMDA for 2 min thr
Autor:
T.P. Obrenovitch, E. Zilkha
Publikováno v:
British Journal of Pharmacology. 117:931-937
1. Spreading depression (SD) is a propagating transient suppression of electrical activity, associated with cellular depolarization, which probably underlies the migraine aura and may contribute to neuronal damage in focal ischaemia. The purpose of t
Publikováno v:
Journal of Neuroscience Methods. 60:1-9
An enzyme-amperometric detector cell is described for flow analysis of glutamate in dialysate emerging from an implanted microdialysis probe. Its small size allows it to be placed within a few centimetres of the animal preparation, reducing the delay
Autor:
E. Zilkha, Tihomir P. Obrenovitch
Publikováno v:
Journal of Neurophysiology. 73:2107-2114
1. Cortical spreading depression (SD) is a propagating transient suppression of electrical activity associated with depolarization, which may contribute to the pathophysiology of important neurological disorders, including cerebral ischemia and migra
Publikováno v:
Analytical Letters. 27:453-473
Two designs of thin film amperometric enzyme biosensor flow cell are described for the on-line measurement of glucose and glutamate concentrations in the extracellular fluid of the brain in conjunction with a microdialysis probe. The biosensors have
Publikováno v:
Analytical Letters. 26:831-849
A novel method of eliminating interferences which arise from electrochemically active substances is described. The sample solutions are passed through a platinum tube electrode inserted into the sample flow line, where they are subjected to DC pre-el
Publikováno v:
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 18(2-3)
Beneficial effects of glutamate-receptor antagonists in models of neurological disorders are often used to support the notion that endogenous excitotoxicity (i.e. resulting from extracellular accumulation of endogenous glutamate) is a major contribut