Výsledky vyhledávání - "E. Xirouchaki"

Akademický článek

MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention

Autor: Bin Qiu, Ahmed Lawan, Chrysovalantou E. Xirouchaki, Jae-Sung Yi, Marie Robert, Lei Zhang, Wendy Brown, Carlos Fernández-Hernando, Xiaoyong Yang, Tony Tiganis, Anton M. Bennett

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Abstract Nonalcoholic steatohepatitis (NASH) is triggered by hepatocyte death through activation of caspase 6, as a result of decreased adenosine monophosphate (AMP)-activated protein kinase-alpha (AMPKα) activity. Increased hepatocellular death pro

Externí odkaz: https://doaj.org/article/7f0cbbbde00c4636bef5fd1be82a4956

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Akademický článek

Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity

Autor: Garron T. Dodd, Chrysovalantou E. Xirouchaki, Matthew Eramo, Christina A. Mitchell, Zane B. Andrews, Belinda A. Henry, Michael A. Cowley, Tony Tiganis

Publikováno v: Cell Reports, Vol 28, Iss 11, Pp 2905-2922.e5 (2019)

Summary: The importance of hypothalamic leptin and insulin resistance in the development and maintenance of obesity remains unclear. The tyrosine phosphatases protein tyrosine phosphatase 1B (PTP1B) and T cell protein tyrosine phosphatase (TCPTP) att

Externí odkaz: https://doaj.org/article/60e76c7095e44457a9a4422b890fabd6

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Data from PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor Immunity

Autor: Tony Tiganis, Nicholas K. Tonks, Phillip K. Darcy, Paul A. Beavis, Roger J. Daly, Kevin Sek, Spencer Greatorex, Samuel J. Hogarth, Chrysovalantou E. Xirouchaki, Pei Kee Goh, Rachel Xu, Mara N. Zeissig, Xin Du, Kun-Hui Lu, Florian Wiede

Immunotherapies aimed at alleviating the inhibitory constraints on T cells have revolutionized cancer management. To date, these have focused on the blockade of cell-surface checkpoints such as PD-1. Herein we identify protein tyrosine phosphatase 1B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e751b3f7f88629ae3ff63080275333a
https://doi.org/10.1158/2159-8290.c.6549505

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Akademický článek

Impaired glucose metabolism and exercise capacity with muscle-specific glycogen synthase 1 (gys1) deletion in adult mice

Autor: Chrysovalantou E. Xirouchaki, Salvatore P. Mangiafico, Katherine Bate, Zheng Ruan, Amy M. Huang, Bing Wilari Tedjosiswoyo, Benjamin Lamont, Wynne Pong, Jenny Favaloro, Amy R. Blair, Jeffrey D. Zajac, Joseph Proietto, Sofianos Andrikopoulos

Publikováno v: Molecular Metabolism, Vol 5, Iss 3, Pp 221-232 (2016)

Objective: Muscle glucose storage and muscle glycogen synthase (gys1) defects have been associated with insulin resistance. As there are multiple mechanisms for insulin resistance, the specific role of glucose storage defects is not clear. The aim of

Externí odkaz: https://doaj.org/article/3e704c6c580b4585935f4d9189422482

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PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor Immunity

Autor: Tony Tiganis, Pei Kee Goh, Chrysovalantou E. Xirouchaki, Spencer Greatorex, Kevin Sek, Paul A. Beavis, Rachel Xu, Xin Du, Samuel J. Hogarth, Phillip K. Darcy, Mara N. Zeissig, Kun-Hui Lu, Roger J. Daly, Florian Wiede, Nicholas K. Tonks

Publikováno v: Cancer Discov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe8179c7b63b6bcc3c67dfaef438480
https://doi.org/10.1158/2159-8290.cd-21-0694

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Hepatocyte-specific miR-33 deletion attenuates NAFLD-NASH-HCC progression

Autor: Pablo Fernández-Tussy, Jonathan Sun, Magdalena P. Cardelo, Nathan L. Price, Leigh Goedeke, Chrysovalantou E. Xirouchaki, Xiaoyong Yang, Oscar Pastor-Rojo, Anton M. Bennett, Tony Tiganis, Yajaira Suárez, Carlos Fernández-Hernando

Publikováno v: bioRxiv

The complexity of the multiple mechanisms underlying non-alcoholic fatty liver disease (NAFLD) progression remains a significant challenge for the development of effective therapeutics. miRNAs have shown great promise as regulators of biological proc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a685c6a02c0c1eb0bf66953c653aed
https://europepmc.org/articles/PMC9882318/

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PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity

Autor: Mara N. Zeissig, Spencer Greatorex, Chrysovalantou E. Xirouchaki, Nicholas K. Tonks, Kevin Sek, Rachel Xu, Pei Kee Goh, Samuel J. Hogarth, Paul A. Beavis, Roger J. Daly, Florian Wiede, Phillip K. Darcy, Xin Du, Tony Tiganis, Kun-Hui Lu

Immunotherapies aimed at alleviating the inhibitory constraints on T cells have revolutionised cancer management. To date, these have focused on the blockade of cell surface checkpoints such as PD-1. Herein we identify protein-tyrosine-phosphatase 1B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8094c4f372999a9062c30382b8ebf209
https://doi.org/10.1101/2021.11.11.468140

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Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance

Autor: Garron T. Dodd, Zane B. Andrews, Tony Tiganis, Mathieu Méquinion, Seung Jae Kim, Chrysovalantou E. Xirouchaki, Jens C. Brüning

Publikováno v: Science Advances

Insulin signaling in the hypothalamus limits the size of meals to prevent postprandial hyperglycemia and insulin resistance.
The importance of hypothalamic insulin signaling on feeding and glucose metabolism remains unclear. We report that insul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141f7770046d41ec14e71f00f425c88b
http://europepmc.org/articles/PMC7909880

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