Zobrazeno 1 - 10
of 1 597
pro vyhledávání: '"E. Wenzel"'
Autor:
Kazuhiro Yamada, Claudette St. Croix, Donna B. Stolz, Yulia Y. Tyurina, Vladimir A. Tyurin, Laura R. Bradley, Alexander A. Kapralov, Yanhan Deng, Xiuxia Zhou, Qi Wei, Bo Liao, Nobuhiko Fukuda, Mara Sullivan, John Trudeau, Anuradha Ray, Valerian E. Kagan, Jinming Zhao, Sally E. Wenzel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract A stable mitochondrial pool is crucial for healthy cell function and survival. Altered redox biology can adversely affect mitochondria through induction of a variety of cell death and survival pathways, yet the understanding of mitochondria
Externí odkaz:
https://doaj.org/article/1c733dcdc5e7478d914aed5291e53938
Autor:
Jamie L. Everman, Satria P. Sajuthi, Maude A. Liegeois, Nathan D. Jackson, Erik H. Collet, Michael C. Peters, Maurizio Chioccioli, Camille M. Moore, Bhavika B. Patel, Nathan Dyjack, Roger Powell, Cydney Rios, Michael T. Montgomery, Celeste Eng, Jennifer R. Elhawary, Angel C. Y. Mak, Donglei Hu, Scott Huntsman, Sandra Salazar, Luigi Feriani, Ana Fairbanks-Mahnke, Gianna L. Zinnen, Cole R. Michel, Joe Gomez, Xing Zhang, Vivian Medina, Hong Wei Chu, Pietro Cicuta, Erin D. Gordon, Pamela Zeitlin, Victor E. Ortega, Nichole Reisdorph, Eleanor M. Dunican, Monica Tang, Brett M. Elicker, Travis S. Henry, Eugene R. Bleecker, Mario Castro, Serpil C. Erzurum, Elliot Israel, Bruce D. Levy, David T. Mauger, Deborah A. Meyers, Kaharu Sumino, David S. Gierada, Annette T. Hastie, Wendy C. Moore, Loren C. Denlinger, Nizar N. Jarjour, Mark L. Schiebler, Sally E. Wenzel, Prescott G. Woodruff, Jose Rodriguez-Santana, Chad G. Pearson, Esteban G. Burchard, John V. Fahy, Max A. Seibold
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives the formation of pathologic mucus which leads to airway mucus plugging. Here we investigate the molecular role and clinical si
Externí odkaz:
https://doaj.org/article/e5fbd453726447a6a3e42371a05beeb5
Autor:
John S. Kim, Yifei Sun, Pallavi Balte, Mary Cushman, Rebekah Boyle, Russell P. Tracy, Linda M. Styer, Taison D. Bell, Michaela R. Anderson, Norrina B. Allen, Pamela J. Schreiner, Russell P. Bowler, David A. Schwartz, Joyce S. Lee, Vanessa Xanthakis, Margaret F. Doyle, Elizabeth A. Regan, Barry J. Make, Alka M. Kanaya, Sally E. Wenzel, Josef Coresh, Carmen R. Isasi, Laura M. Raffield, Mitchell S. V. Elkind, Virginia J. Howard, Victor E. Ortega, Prescott Woodruff, Shelley A. Cole, Joel M. Henderson, Nicholas J. Mantis, Monica M. Parker, Ryan T. Demmer, Elizabeth C. Oelsner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract This study investigates correlates of anti-S1 antibody response following COVID-19 vaccination in a U.S. population-based meta-cohort of adults participating in longstanding NIH-funded cohort studies. Anti-S1 antibodies were measured from dr
Externí odkaz:
https://doaj.org/article/70812139a43e4ea6855d4d113d776773
Autor:
Michelle L. Manni, Victoria A. Heinrich, Gregory J. Buchan, James P. O’Brien, Crystal Uvalle, Veronika Cechova, Adolf Koudelka, Dharti Ukani, Mohamad Rawas-Qalaji, Tim D. Oury, Renee Hart, Madeline Ellgass, Steven J. Mullett, Merritt L. Fajt, Sally E. Wenzel, Fernando Holguin, Bruce A. Freeman, Stacy G. Wendell
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Bile acid profiles are altered in obese individuals with asthma. Thus, we sought to better understand how obesity-related systemic changes contribute to lung pathophysiology. We also test the therapeutic potential of nitro-oleic acid (NO2-OA
Externí odkaz:
https://doaj.org/article/40111bfc71bc4fc1b5f339c0101d5c5d
Autor:
Silva Kasela, Victor E. Ortega, Molly Martorella, Suresh Garudadri, Jenna Nguyen, Elizabeth Ampleford, Anu Pasanen, Srilaxmi Nerella, Kristina L. Buschur, Igor Z. Barjaktarevic, R. Graham Barr, Eugene R. Bleecker, Russell P. Bowler, Alejandro P. Comellas, Christopher B. Cooper, David J. Couper, Gerard J. Criner, Jeffrey L. Curtis, MeiLan K. Han, Nadia N. Hansel, Eric A. Hoffman, Robert J. Kaner, Jerry A. Krishnan, Fernando J. Martinez, Merry-Lynn N. McDonald, Deborah A. Meyers, Robert Paine, Stephen P. Peters, Mario Castro, Loren C. Denlinger, Serpil C. Erzurum, John V. Fahy, Elliot Israel, Nizar N. Jarjour, Bruce D. Levy, Xingnan Li, Wendy C. Moore, Sally E. Wenzel, Joe Zein, NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Charles Langelier, Prescott G. Woodruff, Tuuli Lappalainen, Stephanie A. Christenson
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)
Abstract Background The large airway epithelial barrier provides one of the first lines of defense against respiratory viruses, including SARS-CoV-2 that causes COVID-19. Substantial inter-individual variability in individual disease courses is hypot
Externí odkaz:
https://doaj.org/article/87ab72a86e144f1c976576cc59d3efd7
Autor:
Haider H. Dar, Michael W. Epperly, Vladimir A. Tyurin, Andrew A. Amoscato, Tamil S. Anthonymuthu, Austin B. Souryavong, Alexander A. Kapralov, Galina V. Shurin, Svetlana N. Samovich, Claudette M. St. Croix, Simon C. Watkins, Sally E. Wenzel, Rama K. Mallampalli, Joel S. Greenberger, Hülya Bayır, Valerian E. Kagan, Yulia Y. Tyurina
Publikováno v:
JCI Insight, Vol 7, Iss 4 (2022)
Total body irradiation (TBI) targets sensitive bone marrow hematopoietic cells and gut epithelial cells, causing their death and inducing a state of immunodeficiency combined with intestinal dysbiosis and nonproductive immune responses. We found enha
Externí odkaz:
https://doaj.org/article/064649aa63e64d92892a0366bc434be8
Autor:
Tadao Nagasaki, Alexander J. Schuyler, Jinming Zhao, Svetlana N. Samovich, Kazuhiro Yamada, Yanhan Deng, Scott P. Ginebaugh, Stephanie A. Christenson, Prescott G. Woodruff, John V. Fahy, John B. Trudeau, Detcho Stoyanovsky, Anuradha Ray, Yulia Y. Tyurina, Valerian E. Kagan, Sally E. Wenzel
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 1 (2022)
Altered redox biology challenges all cells, with compensatory responses often determining a cell’s fate. When 15 lipoxygenase 1 (15LO1), a lipid-peroxidizing enzyme abundant in asthmatic human airway epithelial cells (HAECs), binds phosphatidyletha
Externí odkaz:
https://doaj.org/article/45e6d435807b449cbb11a73fc2795bf4
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100847- (2021)
Summary: Bulk expression data from heterogeneous cell populations pose a challenge for investigators, as differences in cell numbers and transcriptional programs may complicate analysis. To improve the performance of bulk RNA sequencing on mixed popu
Externí odkaz:
https://doaj.org/article/4299c19b6f05428b986c836bdf3b8a83
Autor:
Matthew J. Camiolo, Xiuxia Zhou, Qi Wei, Humberto E. Trejo Bittar, Naftali Kaminski, Anuradha Ray, Sally E. Wenzel
Publikováno v:
JCI Insight, Vol 6, Iss 21 (2021)
Asthma is a common disease with profoundly variable natural history and patient morbidity. Heterogeneity has long been appreciated, and much work has focused on identifying subgroups of patients with similar pathobiological underpinnings. Previous st
Externí odkaz:
https://doaj.org/article/ac27576b5c58412c83d0dff478b50aff
Autor:
Haider H. Dar, Tamil S. Anthonymuthu, Liubov A. Ponomareva, Austin B. Souryavong, Galina V. Shurin, Alexandr O. Kapralov, Vladimir A. Tyurin, Janet S. Lee, Rama K. Mallampalli, Sally E. Wenzel, Hülya Bayir, Valerian E. Kagan
Publikováno v:
Redox Biology, Vol 45, Iss , Pp 102045- (2021)
Ferroptosis is a redox-driven type of regulated cell death program arising from maladaptation of three metabolic pathways: glutathione homeostasis, iron handling and lipid peroxidation. Though GSH/Gpx4 is the predominant system detoxifying phospholip
Externí odkaz:
https://doaj.org/article/e3f67850337e451888b65ee03ea99b6a