Výsledky vyhledávání - "E. W. van Tilburg"

N6,5‘-Disubstituted Adenosine Derivatives as Partial Agonists for the Human Adenosine A3 Receptor

Autor: E. W. van Tilburg, Adriaan P. IJzerman, R C Vollinga, A. Lorenzen, J. K. Von Frijtag Drabbe Künzel, M de Groote

Publikováno v: Journal of Medicinal Chemistry. 42:1393-1400

5'-(Alkylthio)-substituted analogues of N6-benzyl- and N6-(3-iodobenzyl)adenosine were synthesized in 37-61% overall yields. The affinities of these compounds for the adenosine A1, A2A, and A3 receptors were determined using rat brain cortex, rat bra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d58b8ff32d4f44c3871a5c76b4818b4
https://doi.org/10.1021/jm981090+

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Improved and semi-automated GMP-compliant radiosynthesis of [11C]docetaxel

Autor: M. van der Meij, Albert D. Windhorst, J. Brinkhorst, E. W. van Tilburg, Martinus P J Mooijer

Publikováno v: Applied Radiation and Isotopes, 66(10), 1414-1418. Elsevier Limited
van Tilburg, E W, Mooijer, M P, Brinkhorst, J, van der, M M & Windhorst, A D 2008, ' Improved and semi-automated GMP-compliant radiosynthesis of [11C]docetaxel ', Applied Radiation and Isotopes, vol. 66, no. 10, pp. 1414-1418 . https://doi.org/10.1016/j.apradiso.2008.02.076

[ 11 C]Docetaxel (Taxotere ® ) has been synthesized via an improved synthesis route, which involves a more efficient intermediate removal of the excess 1,2,2,2-tetrachloroethyl chloroformate. Furthermore, the purification and formulation into a huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0789fc92081dba9df6deb5628d765b
https://research.vumc.nl/en/publications/b113571c-eb32-4eb1-a22a-0c76b0d409b1

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Radiosynthesis of [11C]docetaxel

Autor: D. Elshove, J. J. M. van der Hoeven, M. van der Meij, Adriaan A. Lammertsma, Eric J.F. Franssen, Albert D. Windhorst, E. W. van Tilburg

Publikováno v: Van Tilburg, E W, Franssen, E J F, Van Der Hoeven, J J M, Van Der Meij, M, Elshove, D, Lammertsma, A A & Windhorst, A D 2004, ' Radiosynthesis of [ 11 C]docetaxel ', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 47, no. 11, pp. 763-777 . https://doi.org/10.1002/jlcr.861
Journal of Labelled Compounds and Radiopharmaceuticals, 47(11), 763-777. John Wiley and Sons Ltd

Docetaxel (Taxotere®) is an accepted chemotherapeutic agent for the treatment of breast cancer and non-small cell lung cancers. A potential means of predicting response is measuring tumor uptake of [11C]docetaxel using Positron Emission Tomography (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86442fef0377371a55864ffe5608ca68
https://research.vumc.nl/en/publications/85b15959-0f8f-4b3c-8027-e0f2037b188b

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Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor

Autor: Margot W. Beukers, M de Groote, Adriaan P. IJzerman, P. A. M. Van Der Klein, E. W. van Tilburg

Publikováno v: Bioorganicmedicinal chemistry letters. 11(15)

The synthesis and receptor binding of novel adenosine receptor antagonists is described. We found that non-xanthine 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives may have high affinity and substantial selectivity for the adenosine A(1) rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d34720e627b81c23713e1a64fa70505
https://pubmed.ncbi.nlm.nih.gov/11454470

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Extracellular adenosine-induced apoptosis in mouse neuroblastoma cells: studies on involvement of adenosine receptors and adenosine uptake

Autor: S M, Schrier, E W, van Tilburg, H, van der Meulen, A P, Ijzerman, G J, Mulder, J F, Nagelkerke

Publikováno v: Biochemical pharmacology. 61(4)

The induction of apoptosis by adenosine was studied in the mouse neuroblastoma cell line N1E-115. Apoptosis was characterized by fluorescence and electron microscopy, fluorescence-activated cell sorter (FACS) analysis, and caspase activity assays. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::63dd3de203d2c94ce9edce1fb491fdf6
https://pubmed.ncbi.nlm.nih.gov/11226375

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