Zobrazeno 1 - 9 of 9 pro vyhledávání: '"E. W. F. W. Alton"'
2
‘Soluble’: Decision-making in the diagnosis of Jaundice
Autor: D. Fok, N. Newman, J. Hooper, F. R. Vicary, E. W. F. W. Alton
Publikováno v: International Journal of Bio-Medical Computing. 27:47-57
We have designed a computer program ‘Solubile’ to aid clinicians in the diagnosis of jaundice. Based on Bayes' theorem, ‘Solubile’ uses up to 47 items of information about the patient to produce the most probable diagnosis from 22 possible di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afa79f2a07bb5e674a6cf4ebec54159
https://doi.org/10.1016/0020-7101(91)90020-f
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3
Gene therapy for cystic fibrosis: steady progress, should do well
Autor: E. W. F. W. Alton, D. M. Geddes
Publikováno v: European Respiratory Journal. 10:257-259
In the early 1990s, when clinical gene therapy trials were initiated for a number of diseases, including cystic fibrosis (CF), there was great expectation both amongst the general public and in some quarters of the scientific and medical profession t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bac3550a8426d7c16a2a08f2b0d9723
https://doi.org/10.1183/09031936.97.10020257
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4
Gene therapy progress and prospects: cystic fibrosis
Autor: U Griesenbach, S Ferrari, D M Geddes, E W F W Alton
Publikováno v: Gene Therapy
Since the cloning of the cystic fibrosis gene (CFTR) in 1989, 18 clinical trials have been carried out, including five in the 2 years reviewed here. Most trials demonstrated proof-of-principle for gene transfer to the airway. However, gene transfer e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44332a369ec7bf5d05ac45debafae2c4
https://pubmed.ncbi.nlm.nih.gov/12364999
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5
The CF gene: 10 years on
Autor: D M Geddes, E W F W Alton
Publikováno v: Thorax. 54(12)
These days everyone is looking for genes. Grant money, media interviews, self-esteem, Nobel prizes, and lots of interesting biology lure researchers into molecular genetics, and diseases as diverse as asthma, chronic obstructive pulmonary disease and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::725e982e17ab440f2f524f93e4e165af
https://pubmed.ncbi.nlm.nih.gov/10567621
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7
Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice
Autor: E. W. F. W. Alton, P. G. Middleton, N. J. Caplen, S. N. Smith, D. M. Steel, F. M. Munkonge, P. K. Jeffery, D. M. Geddes, S. L. Hart, R. Williamson, K. I. Fasold, A. D. Miller, P. Dickinson, B. J. Stevenson, G. McLachlan, J. R. Dorin, D. J. Porteous
Publikováno v: Nature genetics. 5(2)
We report gene transfer to the Edinburgh insertional mutant mouse (cf/cf), delivering CFTR cDNA-liposome complexes into the airways by nebulization. We show full restoration of cAMP related chloride responses in some animals and demonstrate, in the s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f8764e040310608fde86f761df1599
https://pubmed.ncbi.nlm.nih.gov/7504552
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9
Microcomputer-aided Diagnosis of Jaundice (Solubile)
Autor: J. Hooper, E. W. F. W. Alton, N. Newman, F. R. Vicary
Publikováno v: Computers in Gastroenterology ISBN: 9781447132615
There have been many attempts to use computers as aids to diagnosis. Increasingly, attention has been focused on the differentiation of a number of possible diseases given a particular presenting symptom (such as abdominal pain: DeDombal et al. 1972)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd17bd0c6250f712c1f57d659b60cca7
https://doi.org/10.1007/978-1-4471-3259-2_23
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