Zobrazeno 1 - 10 of 42 pro vyhledávání: '"E. W. Blank"'
1
Initial clinical evaluation of radiolabeled MX-DTPA humanized BrE-3 antibody in patients with advanced breast cancer
Autor: E L, Kramer, L, Liebes, C, Wasserheit, M E, Noz, E W, Blank, A, Zabalegui, J, Melamed, P, Furmanski, J A, Peterson, R L, Ceriani
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 4(7)
To evaluate radiometal-labeled humanized BrE-3 (huBrE-3) monoclonal antibody as a radioimmunolocalization and therapeutic agent in breast cancer patients, tumor localization, pharmacokinetics, radiation dosimetry, and immunogenicity of (111)In-labele
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bed8a63f16a388c0ea147c352a097f81
https://pubmed.ncbi.nlm.nih.gov/9676842
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2
Effect of multiple, repeated doses of radioimmunotherapy on target antigen expression (breast MUC-1 mucin) in breast carcinomas
Autor: J A, Peterson, E W, Blank, R L, Ceriani
Publikováno v: Cancer research. 57(6)
The effect of radioimmunotherapy (RIT) on target antigen expression was studied in breast carcinomas transplanted in immunodeficient mice. In nine separate experiments, a single dose of 1500 microCi of 131I-labeled monoclonal antibody (MAb) Mc5 was g
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::60a4553df1d78198110b33cd287f0eb7
https://pubmed.ncbi.nlm.nih.gov/9067279
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3
Biological activity of two humanized antibodies against two different breast cancer antigens and comparison to their original murine forms
Autor: R L, Ceriani, E W, Blank, J R, Couto, J A, Peterson
Publikováno v: Cancer research. 55
We have humanized two monoclonal antibodies (MoAbs), hu-BrE-3 and hu-Mc3, that are bound to two different antigens of the breast epithelial cell. They bind to the breast epithelial mucin (M(r) 400,000) and the BA46 antigen (M(r) 46,000). They could p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::afe87bb8497be5b17b20d384abe03115
https://pubmed.ncbi.nlm.nih.gov/7493359
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4
Anti-BA46 monoclonal antibody Mc3: humanization using a novel positional consensus and in vivo and in vitro characterization
Autor: J R, Couto, E W, Blank, J A, Peterson, R L, Ceriani
Publikováno v: Cancer research. 55(8)
Mc3 is a murine mAb that is highly effective in treating breast tumors in experimental radioimmunotherapy. Mc3 binds to BA46, a 46-kDa glycoprotein of the human milk fat globule membrane that is also expressed in breast carcinoma cells. We cloned and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::07c6af23129b3859738c07abb587ba95
https://pubmed.ncbi.nlm.nih.gov/7712480
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7
5-Iododeoxyuridine increases the efficacy of the radioimmunotherapy of human tumors growing in nude mice
Autor: O, Santos, K D, Pant, E W, Blank, R L, Ceriani
Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 33(8)
Recently, there has been much interest in the use of radionuclide conjugated monoclonal antibodies for the treatment of human malignancies. One way to potentially maximize the therapeutic effectiveness of radioimmunotherapy would be to sensitize tumo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f39debb0333bff7f339b878fc2be3b8
https://pubmed.ncbi.nlm.nih.gov/1634946
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