Zobrazeno 1 - 10
of 1 604
pro vyhledávání: '"E. Vaughan"'
Autor:
A. Liew, C. Baustian, D. Thomas, E. Vaughan, C. Sanz-Nogués, M. Creane, X. Chen, S. Alagesan, P. Owens, J. Horan, P. Dockery, M. D. Griffin, A. Duffy, T. O’Brien
Publikováno v:
Cell Transplantation, Vol 27 (2018)
Intramuscular administration of mesenchymal stromal cells (MSCs) represents a therapeutic option for diabetic critical limb ischemia. Autologous or allogeneic approaches may be used but disease-induced cell dysfunction may limit therapeutic efficacy
Externí odkaz:
https://doaj.org/article/3698c355a75c4e9a936cf7c9256d85a1
Autor:
L. K. Metthew Lam, Emily Oatman, Kaitlyn A. Eckart, Nathan J. Klingensmith, Emily Flowers, Layal Sayegh, Julia Yuen, Rebecca L. Clements, Nuala J. Meyer, Kellie A. Jurado, Andrew E. Vaughan, Stephanie C. Eisenbarth, Nilam S. Mangalmurti
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Red blood cells (RBCs) express the nucleic acid-binding toll-like receptor 9 (TLR9) and bind CpG-containing DNA. However, whether human RBCs express other nucleic acid-binding TLRs is unknown. Here we show that human RBCs express the RNA sen
Externí odkaz:
https://doaj.org/article/afd7120448ec4e1f9581ca8408fd6e8a
Autor:
Gan Zhao, Maria E. Gentile, Lulu Xue, Christopher V. Cosgriff, Aaron I. Weiner, Stephanie Adams-Tzivelekidis, Joanna Wong, Xinyuan Li, Sara Kass-Gergi, Nicolas P. Holcomb, Maria C. Basal, Kathleen M. Stewart, Joseph D. Planer, Edward Cantu, Jason D. Christie, Maria M. Crespo, Michael J. Mitchell, Nuala J. Meyer, Andrew E. Vaughan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Inflammation induced by lung infection is a double-edged sword, moderating both anti-viral and immune pathogenesis effects; the mechanism of the latter is not fully understood. Previous studies suggest the vasculature is involved in tissue i
Externí odkaz:
https://doaj.org/article/298e4f96eba74047b28b7e392be57e41
Autor:
Carrie A. M. Wegh, Margriet H. C. Schoterman, Elaine E. Vaughan, Sofie C. C. van der Zalm, Hauke Smidt, Clara Belzer, Marc A. Benninga
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-9 (2024)
Abstract Background Functional constipation (FC) in children is a common gastrointestinal disorder with a worldwide-pooled prevalence of 9.5%. Complaints include infrequent bowel movements, painful defecation due to hard and/or large stools, faecal i
Externí odkaz:
https://doaj.org/article/b1996ee56c984a75a8c1e3e0b26bd1e4
Autor:
Xuexiang Han, Junchao Xu, Ying Xu, Mohamad-Gabriel Alameh, Lulu Xue, Ningqiang Gong, Rakan El-Mayta, Rohan Palanki, Claude C. Warzecha, Gan Zhao, Andrew E. Vaughan, James M. Wilson, Drew Weissman, Michael J. Mitchell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The ionizable lipidoid is a key component of lipid nanoparticles (LNPs). Degradable lipidoids containing extended alkyl branches have received tremendous attention, yet their optimization and investigation are underappreciated. Here, we devi
Externí odkaz:
https://doaj.org/article/5c7c469fc7ef44afbf32232dfd7a12e4
Autor:
Lulu Xue, Alex G. Hamilton, Gan Zhao, Zebin Xiao, Rakan El-Mayta, Xuexiang Han, Ningqiang Gong, Xinhong Xiong, Junchao Xu, Christian G. Figueroa-Espada, Sarah J. Shepherd, Alvin J. Mukalel, Mohamad-Gabriel Alameh, Jiaxi Cui, Karin Wang, Andrew E. Vaughan, Drew Weissman, Michael J. Mitchell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Lipid nanoparticles for delivering mRNA therapeutics hold immense promise for the treatment of a wide range of lung-associated diseases. However, the lack of effective methodologies capable of identifying the pulmonary delivery profile of ch
Externí odkaz:
https://doaj.org/article/5610f990ab3349ad8170012a73e2cbb4
Autor:
Ling Qiu, Dylan Chirman, Justin R. Clark, Yikun Xing, Haroldo Hernandez Santos, Ellen E. Vaughan, Anthony W. Maresso
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
The emergence of antimicrobial resistance (AMR) is a principal global health crisis projected to cause 10 million deaths annually worldwide by 2050. While the Gram-negative bacteria Escherichia coli is commonly found as a commensal microbe in the hum
Externí odkaz:
https://doaj.org/article/d5792eca43de42c48797fcce0e81af56
Autor:
Kazushige Shiraishi, Michael P. Morley, Dakota L. Jones, Gan Zhao, Aaron I. Weiner, Maria C. Basil, Edward Cantu, Laura T. Ferguson, Michele Oyster, Apoorva Babu, Yun Ying, Su Zhou, Shanru Li, Andrew E. Vaughan, Edward E. Morrisey
Publikováno v:
npj Regenerative Medicine, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract Maintenance of the cellular boundary between airway and alveolar compartments during homeostasis and after injury is essential to prohibit pathological plasticity which can reduce respiratory function. Lung injury and disease can induce eith
Externí odkaz:
https://doaj.org/article/4486089a25224937b86b481d6f45d135
Autor:
Anthony M. Steinle, Jeffrey W. Chen, Alexander O'Brien, Wilson E. Vaughan, Andrew J. Croft, W. Hunter Waddell, Justin Vickery, Robert W. Elrod, Hani Chanbour, Julian Lugo-Pico, Scott L. Zuckerman, Amir M. Abtahi, Byron F. Stephens
Publikováno v:
Spine Surgery and Related Research, Vol 7, Iss 3, Pp 242-248 (2023)
Introduction: Despite recent advances in applied instruments and surgical techniques, the incidence of iatrogenic durotomies caused by traditional techniques remains significant. The ultrasonic bone scalpel (UBS) has been shown to improve speed and r
Externí odkaz:
https://doaj.org/article/d11f74535a694fad89165d6bef3bd875
Autor:
Emma W. Littleton, Anita Shepherd, Anna B. Harper, Astley F. S. Hastings, Naomi E. Vaughan, Jonathan Doelman, Detlef P. vanVuuren, Timothy M. Lenton
Publikováno v:
GCB Bioenergy, Vol 15, Iss 3, Pp 303-318 (2023)
Abstract Large‐scale bioenergy plays a key role in climate change mitigation scenarios, but its efficacy is uncertain. This study aims to quantify that uncertainty by contrasting the results of three different types of models under the same mitigat
Externí odkaz:
https://doaj.org/article/9e3d8f75a54e46b190e5f0c6847aec88