Zobrazeno 1 - 10
of 61
pro vyhledávání: '"E. V. USPENSKAYA"'
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 11, Iss 4, Pp 28-39 (2022)
Introduction. The review is dedicated to the scientific analysis of the composition, properties and features of the biological effects on the man's organism of the Lycium Fruit as a prospective plant raw material for the production of innovative drug
Externí odkaz:
https://doaj.org/article/4654e435ba4a47b9acf8cb97e2305304
Autor:
A. V. Syroeshkin, T. E. Elizarova, T. V. Pleteneva, E. V. Uspenskaya, O. V. Levitskaya, I. A. Zlatskiy, T. V. Maksimova
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 9, Iss 2, Pp 24-32 (2020)
Introduction. The study discusses the hydrogen isotope 2H effect on the biological activity of pharmaceutical substances.Text. Two aspects of the deuterium effect on the properties of active pharmaceutical ingredients and excipients are considered. T
Externí odkaz:
https://doaj.org/article/3c702cec65ce45ee9a3fb55f9a30edf4
Determination of Active Pharmaceutical Substances Dissolution Rate by Laser Light Diffraction Method
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 9, Iss 1, Pp 75-81 (2020)
Introduction. The strategy of quality control of drugs provides for compliance with the requirements of regulatory documentation methods and critical quality indicators that determine its effectiveness. Special attention should be paid to the propert
Externí odkaz:
https://doaj.org/article/d8470b3daa3241048df1bfdef8c3efe2
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 4, Pp 152-157 (2019)
Drug release studies (or in vitro release) of valsartan in three dissolution media simulating the main sections of the gastrointestinal tract were conducted. The concentrations were determined using UV/Vis spectrophotometer (Varian Cary 50) at 254 nm
Externí odkaz:
https://doaj.org/article/810a4287d6394c1f887401b6eb033785
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 1, Pp 150-155 (2019)
The kinetic evaluation of solubility of drug substances of different chemical and pharmacological groups (bendazol hydrochloride, lactose monohydrate and taurine) was conducted in aqueous solutions with different isotopic composition of hydrogen. The
Externí odkaz:
https://doaj.org/article/a261d91f72624173ba54a13aa76b6b76
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 2, Pp 72-76 (2019)
Solubility is the most important quality indicator, reflecting the physicochemical properties of active pharmaceutical ingredients (APIs). Prior to the release of API, solubility is one of the key factors affecting the efficacy and safety of drugs. T
Externí odkaz:
https://doaj.org/article/dc5dbacb89b14a94880f2965e4536ced
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 0, Iss 1, Pp 25-28 (2018)
Two optical methods - polarimetry and laser light diffraction - have been used to study valine aqueous solutions. It has been shown that optical activity of valine enantiomers depends on deuterium content in aqueous solutions. The influence of deuter
Externí odkaz:
https://doaj.org/article/28c8285690e84b01906c525768f80bfc
Autor:
A. V. Syroeshkin, T. V. Pleteneva, M. A. Morozova, E. V. Uspenskaya, O. V. Titorovich, E. V. Lesnikov, V. I. Dobrovolsky
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 0, Iss 3, Pp 31-36 (2018)
Processing of interferon gamma antibodies, which involves gradual reduction of the concentration, induces the formation of deuterium-stabilized giant heterophase clusters (GHCs) of water characterized by the specific size spectrum and kinetics of for
Externí odkaz:
https://doaj.org/article/fc7aba22b9b14fe59477ce43f6dcb167
Autor:
A. V. Syroeshkin, E. V. Uspenskaya, T. V. Pleteneva, M. A. Morozova, I. A. Zlatskiy, A. M. Koldina, M. V. Nikiforova
Publikováno v:
The Scientific World Journal, Vol 2018 (2018)
This study demonstrates the link between the modification of the solid-phase pharmaceutical substances mechanical structure and their activity in waters with different molar ratio «deuterium-protium». Mechanochemical transformation of the powders o
Externí odkaz:
https://doaj.org/article/710c9e7def7f4d26b5e14297f04857d0
Autor:
T. V. Pleteneva, O. V. Levitskaya, S. N. Novikova, Igor Zlatskiy, Irina V. Tarabrina, E. V. Uspenskaya, Anton Syroeshkin
Publikováno v:
International Journal of Applied Pharmaceutics. :65-73
The review is devoted to the influence of the hydrogen isotope–deuterium on biological models of organisms and the biological activity of pharmaceutical substances. The positions of the influence of deuterium on the properties of active pharmaceuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66171bb09dccadcd7c534d21c0be2771
https://doi.org/10.22159/ijap.2021v13i4.41818
https://doi.org/10.22159/ijap.2021v13i4.41818