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Native and engineered extracellular vesicles (EVs) generated from human megakaryocytes (huMkEVs) or from the human megakaryocytic cell line CHRF (CHEVs) interact with tropism delivering their cargo to both human and murine hematopoietic stem and prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c3edf62da3138d7880d34022829fb38
https://doi.org/10.1101/2023.04.11.536479
https://doi.org/10.1101/2023.04.11.536479
Autor:
Timothy A. Whitehead, Amanda M. Lewis, Christina Chan, Chien-Ting Li, E. Terry Papoutsakis, Michael J. Betenbaugh, Scott Banta, William E. Bentley, Steffen Schaffer, Rashmi Kshirsagar, Michael C. Jewett, Mattheos A. G. Koffas, Douglas S. Clark, Ian Wheeldon, Laura Segatori, Costas D. Maranas, Beth Junker, Corinne A. Hoesli, Kristala L. J. Prather
Publikováno v:
PMC
Biotechnol Bioeng
Biotechnol Bioeng
© 2020 Wiley Periodicals LLC Today's Biochemical Engineer may contribute to advances in a wide range of technical areas. The recent Biochemical and Molecular Engineering XXI conference focused on “The Next Generation of Biochemical and Molecular E
Publikováno v:
Metabolic Engineering. 45:67-74
Methane, the main component of natural gas, can be used to produce methanol which can be further converted to other valuable products. There is increasing interest in using biological systems for the production of fuels and chemicals from methanol, t
Autor:
Yu-Sin Jang, E. Terry Papoutsakis, Jung-Hee Cho, Doyoung Seung, Jin-dal-rae Choi, Hyohak Song, Sang Yup Lee, George N. Bennett
Publikováno v:
Biotechnology and Bioprocess Engineering. 18:266-271
Corn steep liquor (CSL) obtained from a commercial starch manufacturing process was analyzed and tested as a complex nutrient source for ABE (acetone, butanol, and ethanol) production by Clostridium acetobutylicum PJC4BK_AdhE1. CSL contained a wealth
Autor:
Do Young Seung, E. Terry Papoutsakis, Sang Yup Lee, Byung-Kwan Cho, Changhee Cho, George N. Bennett, Kyung-Jin Kim, Donghui Choe, Yu-Sin Jang, Won Jun Kim
Publikováno v:
Biotechnology journal. 12(2)
Previously the development of a hyper acetone-butanol-ethanol (ABE) producing Clostridium acetobutylicum BKM19 strain capable of producing 30.5% more total solvent by random mutagenesis of its parental strain PJC4BK, which is a buk mutant C. acetobut
Autor:
Peter G. Fuhrken, E. Terry Papoutsakis, Weiqi Huang, Hao Wang, Elizabeth A. Eklund, Yu Feng Lu
Publikováno v:
Journal of Biological Chemistry. 282:16164-16176
HoxA10 is a homeodomain transcription factor that is frequently overexpressed in human acute myeloid leukemia. In murine bone marrow transplantation studies, HoxA10 overexpression induces a myeloproliferative disorder with accumulation of mature phag
Autor:
Kelvin H. Lee, E. Terry Papoutsakis, Matthew T. Ralston, Shuyu Hou, Keerthi P. Venkataramanan, Lie Min, Shawn William Jones
Publikováno v:
Biotechnology for Biofuels
Background Clostridium acetobutylicum is a model organism for both clostridial biology and solvent production. The organism is exposed to its own toxic metabolites butyrate and butanol, which trigger an adaptive stress response. Integrative analysis
Publikováno v:
Nucleic Acids Research. 32:1973-1981
Prokaryotic genes are frequently organized in multicistronic operons (or transcriptional units, TUs), and usually the regulatory motifs for the whole TU are located upstream of the first TU gene. Although the number of sequenced genomes has increased
Publikováno v:
Experimental Hematology. 29:873-883
Objective We have recently reported that 20% O 2 significantly enhances total megakaryocyte (Mk) number, polyploidy, and proplatelet formation compared to 5% O 2 in culture. In order to further elucidate the regulatory role of pO 2 on megakaryocytopo
Publikováno v:
British Journal of Haematology. 111:879-889
Megakaryocytes (Mks) mature adjacent to bone marrow (BM) sinus walls and subsequently release platelets within the sinusoidal space or in lung capillaries. As the sites for platelet release have higher levels of oxygen tension (pO2) than the core of