Výsledky vyhledávání - "E. Tarnowski"

Activating transcription factor-4 promotes neuronal death induced by Parkinson’s disease neurotoxins and α-synuclein aggregates

Autor: Heather E. Tarnowski-Garner, Matthew D. Demmings, Gillian N. Petroff, Elizabeth C. Tennyson, Sean P. Cregan

Publikováno v: Cell Death Differ

Parkinson’s disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra resulting in severe and progressive motor impairments. However, the mechanisms underlying this neuronal loss remain la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473b62f8286bfbf7c148432a92024551
https://doi.org/10.1038/s41418-020-00688-6

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ATF4 regulates neuronal death in models of Parkinson’s Disease

Autor: Matthew D. Demmings, Gillian N. Petroff, Heather E. Tarnowski-Garner, Sean P. Cregan

Parkinson’s Disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra resulting in severe motor impairments. However, the mechanisms underlying this neuronal loss remain largely unknown. Activating Transcription Fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179cb98d99d6211c236626f58c1d8732
https://doi.org/10.1101/783795

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Relatively high rates of G:C → A:T transitions at CpG sites were observed in certain epithelial tissues including pancreas and submaxillary gland of adult big blue® mice

Autor: Sarmitha Sathiamoorthy, Laura Creamer, Kathleen A. Hill, Heather E. Tarnowski, Anita Prtenjaca, Alison M. Marr, Melanie A. Heney

Publikováno v: Environmental and Molecular Mutagenesis. 55:51-63

With few exceptions, spontaneous mutation frequency and pattern are similar across tissue types and relatively constant in young to middle adulthood in wild type mice. Underrepresented in surveys of spontaneous mutations across murine tissues is the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9490f13561f93d3e6b6810c20d9354db
https://doi.org/10.1002/em.21816

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Structural and genic characterization of stable genomic regions in breast cancer: Relevance to chemotherapy

Autor: Heather E. Tarnowski, Peter K. Rogan, Nicole I. Park, Joan H.M. Knoll

Publikováno v: Molecular Oncology. 6:347-359

Cancer genomes accumulate frequent and diverse chromosomal abnormalities as well as gene mutations but must maintain the ability to survive in vivo. We hypothesize that genetic selection acts to maintain tumour survival by preserving copy number of s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5360d0b0cfe51d40aace7a02aed304
https://doi.org/10.1016/j.molonc.2012.01.001

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The Evolution of Cold Tolerance inDrosophilaLarvae

Autor: Lauren A. Strachan, Katie E. Marshall, Brent J. Sinclair, Heather E. Tarnowski-Garner

Publikováno v: Physiological and Biochemical Zoology. 84:43-53

Temperature is a primary determinant of insect and other ectotherm distribution and activity. Physiological and behavioral adaptations allow many insects to survive at subzero temperatures, yet the evolutionary influences on insect cold tolerance are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544277647c81f3d2287032fc6adb88e8
https://doi.org/10.1086/657147

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Relatively high rates of G:C → A:T transitions at CpG sites were observed in certain epithelial tissues including pancreas and submaxillary gland of adult big blue® mice

Autor: Anita, Prtenjaca, Heather E, Tarnowski, Alison M, Marr, Melanie A, Heney, Laura, Creamer, Sarmitha, Sathiamoorthy, Kathleen A, Hill

Publikováno v: Environmental and molecular mutagenesis. 55(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22b4c77e9c304d37934149e37bc31983
https://pubmed.ncbi.nlm.nih.gov/24105921

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