Výsledky vyhledávání - "E. T. Joannides"

Structure-activity relationships of quinolone agents against mycobacteria: effect of structural modifications at the 8 position

Autor: Stephen J. Gracheck, John M. Domagala, Robert C. Reynolds, Gregory E. Roland, Julie A. Dever, Martin A. Shapiro, M R Jacobs, Thomas E. Renau, E. T. Joannides, Joseph P. Sanchez, Jeffrey W. Gage

Publikováno v: Antimicrobial Agents and Chemotherapy. 40:2363-2368

A series of quinolones with substitutions at the 8 position has been prepared as part of a study to examine the relationship between structural modifications at this position and activity against mycobacteria. The compounds were prepared by procedure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9e9c9ee18fab082ca1f24d37eb8490
https://doi.org/10.1128/aac.40.10.2363

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ChemInform Abstract: New 8-(Trifluoromethyl)-Substituted Quinolones. The Benefits of the 8- Fluoro Group with Reduced Phototoxic Risk

Autor: Martin A. Shapiro, Joseph P. Sanchez, D. L. Szotek, Alexander James Bridges, J. C. Sesnie, E. T. Joannides, Rocco D. Gogliotti, Ruth A. Bucsh, Susan Elizabeth Hagen, John M. Domagala, Carl L. Heifetz

Publikováno v: ChemInform. 23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81611c5ed7c6448bd748f77f508e646e
https://doi.org/10.1002/chin.199242177

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In vivo therapeutic efficacies of PD 138312 and PD 140248, two novel fluoronaphthyridines with outstanding gram-positive potency

Autor: J. C. Sesnie, S R Vanderroest, E. T. Joannides, Julie A. Dever, Martin A. Shapiro

PD 138312 and PD 140248 are novel broad-spectrum 7-pyrrolidinyl fluoronaphthyridines with a cyclopropyl or a difluorophenyl substitution at the 1 positions, respectively. They have been demonstrated to have excellent in vitro activity against gram-po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa09137ada3dc40fc826876bc83dac1
https://europepmc.org/articles/PMC162910/

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New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk

Autor: J P, Sanchez, A J, Bridges, R, Bucsh, J M, Domagala, R D, Gogliotti, S E, Hagen, C L, Heifetz, E T, Joannides, J C, Sesnie, M A, Shapiro

Publikováno v: Journal of medicinal chemistry. 35(2)

A series of 8-(trifluoromethyl)-substituted quinolones has been prepared and evaluated for in vitro and in vivo antibacterial activity, and phototolerance in a mouse phototolerance assay. These analogues were compared to the corresponding series of 6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896a80d210cb414787072f2d87220488
https://pubmed.ncbi.nlm.nih.gov/1732554

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