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ChemInform Abstract: Synthesis of Ellipticine and Olivacine by the Thermal Electrocyclic Reaction via Pyridine 3,4-Quinodimethane Intermediates

Autor: Satoshi Hibino, E. Sugino

Publikováno v: ChemInform. 22

A synthesis of the antitumor alkaloids ellipticine 1 and olivacine 2 is reported. The route involves a thermal electrocyclic reaction of conjugated hexatriene system 4 derived from 2-alkenylindole derivatives 5. Heating of the 2-alkenylindole derivat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e208bb0e15e93f5feef13a34e1ce1da4
https://doi.org/10.1002/chin.199111320

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Pharmacokinetics of 9alpha-fluoromedroxyprogesterone acetate in rats: comparison with medroxyprogesterone acetate

Autor: D, Kozutsumi, A, Kawashima, T, Sugimoto, Y, Kotohda, S, Fujimori, M, Takami, T, Kohno, T, Oikawa, E, Sugino, T, Choshi, S, Hibino

Publikováno v: Biopharmaceuticsdrug disposition. 20(6)

Medroxyprogesterone acetate (MPA) is widely used in endocrine therapy for breast cancer and other diseases. Recently, it has been demonstrated that 9alpha-fluoromedroxyprogesterone acetate (FMPA) also has anti-tumour activity in chemical-induced rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e08c217af8c9f01ebe090d3b00ce74a
https://pubmed.ncbi.nlm.nih.gov/10701698

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Catalytic properties of carbonyl reductase from rabbit liver for analogs of acetohexamide and 4-acetylpyridine

Autor: Y, Imamura, T, Koga, T, Higuchi, M, Otagiri, E, Sugino, S, Hibino, S, Nagumo, H, Akita

Publikováno v: Biochemistry and molecular biology international. 33(5)

A correlation was observed between the values of specificity constant (kcat/Km) of carbonyl reductase from rabbit liver for acetohexamide analogs and their partition coefficients. This result indicates that the hydrophobicity in straight-chain alkyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::92040abbc2f7372e6a651bc3a223bfda
https://pubmed.ncbi.nlm.nih.gov/7987258

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Purification and properties of carbonyl reductase from rabbit kidney

Autor: Masaki Otagiri, Toshiyuki Higuchi, E. Sugino, Satoshi Hibino, Yoshihide Nozaki, Yorishige Imamura

Publikováno v: Archives of biochemistry and biophysics. 300(2)

An enzyme catalyzing the metabolic reduction of acetohexamide, an oral antidiabetic drug, has been purified from the cytosolic fraction of rabbit kidney to apparent homogeneity by various chromatographic techniques. The purified enzyme consists of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc239b6348aa195fba45962b422712f7
https://pubmed.ncbi.nlm.nih.gov/8382027

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