Study protocol: a pragmatic, cluster-randomized controlled trial to evaluate the effect of implementation of the Truenat platform/MTB assays at primary health care clinics in Mozambique and Tanzania (TB-CAPT CORE)

Autor: V. N. Leukes, J. Hella, I. Sabi, M. Cossa, C. Khosa, B. Erkosar, C. Mangu, E. Siyame, B. Mtafya, A. Lwilla, S. Viegas, C. Madeira, A. Machiana, J. Ribeiro, A. L. Garcia-Basteiro, F. Riess, D. Elísio, M. Sasamalo, G. Mhalu, C. M. Denkinger, M. D. M. Castro, S. Bashir, S. G. Schumacher, E. Tagliani, A. Malhotra, D. Dowdy, C. Schacht, J. Buech, D. Nguenha, N. Ntinginya, M. Ruhwald, A. Penn-Nicholson, K. Kranzer, TB-CAPT Consortium

Publikováno v: BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-12 (2024)

Abstract Background In 2020, the WHO-approved Molbio Truenat platform and MTB assays to detect Mycobacterium tuberculosis complex (MTB) and resistance to rifampicin directly on sputum specimens. This primary health care center-based trial in Mozambiq

Externí odkaz: https://doaj.org/article/9e5a54ac3fab41c59c8f932721bcec7a

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Adjunctive N-Acetylcysteine and Lung Function in Pulmonary Tuberculosis.

Autor: Wallis RS; The Aurum Institute, Johannesburg.; Department of Medicine, Case Western Reserve University, Cleveland.; Department of Medicine, Vanderbilt University, Nashville., Sabi I; National Institute for Medical Research-Mbeya Medical Research Center, Mbeya, Tanzania., Lalashowi J; National Institute for Medical Research-Mbeya Medical Research Center, Mbeya, Tanzania., Bakuli A; Institute of Infectious Diseases and Tropical Medicine, Ludwig Maximilian University Hospital, Munich, Germany., Mapamba D; National Institute for Medical Research-Mbeya Medical Research Center, Mbeya, Tanzania., Olomi W; National Institute for Medical Research-Mbeya Medical Research Center, Mbeya, Tanzania., Siyame E; National Institute for Medical Research-Mbeya Medical Research Center, Mbeya, Tanzania., Ngaraguza B; National Institute for Medical Research-Mbeya Medical Research Center, Mbeya, Tanzania., Chimbe O; National Institute for Medical Research-Mbeya Medical Research Center, Mbeya, Tanzania., Charalambous S; The Aurum Institute, Johannesburg.; Department of Medicine, Vanderbilt University, Nashville., Rachow A; Institute of Infectious Diseases and Tropical Medicine, Ludwig Maximilian University Hospital, Munich, Germany.; German Centre for Infection Research, Partner Site Munich, Munich, Germany.; Unit Global Health, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Neuherberg, Germany., Ivanova O; Institute of Infectious Diseases and Tropical Medicine, Ludwig Maximilian University Hospital, Munich, Germany.; German Centre for Infection Research, Partner Site Munich, Munich, Germany.; Unit Global Health, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Neuherberg, Germany., Zurba L; Education for Health Africa, Durban, South Africa., Myombe B; National Institute for Medical Research-Mbeya Medical Research Center, Mbeya, Tanzania., Kunambi R; National Institute for Medical Research-Mbeya Medical Research Center, Mbeya, Tanzania., Hoelscher M; Institute of Infectious Diseases and Tropical Medicine, Ludwig Maximilian University Hospital, Munich, Germany.; German Centre for Infection Research, Partner Site Munich, Munich, Germany.; Unit Global Health, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Neuherberg, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP; Immunology, Infection and Pandemic Research, Munich, Germany., Ntinginya N; National Institute for Medical Research-Mbeya Medical Research Center, Mbeya, Tanzania., Churchyard G; The Aurum Institute, Johannesburg.; Department of Medicine, Vanderbilt University, Nashville.

Publikováno v: NEJM evidence [NEJM Evid] 2024 Sep; Vol. 3 (9), pp. EVIDoa2300332. Date of Electronic Publication: 2024 Aug 27.