Zobrazeno 1 - 10
of 19
pro vyhledávání: '"E. Sila Ozdemir"'
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 6 (2024)
ABSTRACT There is a growing interest in the use of probiotic bacteria as biosensors for the detection of disease. However, there is a lack of bacterial receptors developed for specific disease biomarkers. Here, we have investigated the use of the pep
Externí odkaz:
https://doaj.org/article/e0e3da1ed7584f30838b67b0d840ad90
Autor:
Hillary H. Le, Suleyman S. Cinaroglu, Elise C. Manalo, Aysegul Ors, Michelle M. Gomes, Burcin Duan Sahbaz, Karla Bonic, Carlos A. Origel Marmolejo, Arnaud Quentel, Justin S. Plaut, Taryn E. Kawashima, E. Sila Ozdemir, Sanjay V. Malhotra, Yavuz Ahiska, Ugur Sezerman, Gunseli Bayram Akcapinar, Joshua C. Saldivar, Emel Timucin, Jared M. Fischer
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103646- (2021)
Background: Senescent cells accumulate in tissues over time as part of the natural ageing process and the removal of senescent cells has shown promise for alleviating many different age-related diseases in mice. Cancer is an age-associated disease an
Externí odkaz:
https://doaj.org/article/e47bd46165a546c3a103052aa9b58199
Publikováno v:
Viruses, Vol 14, Iss 6, p 1129 (2022)
The COVID-19 pandemic began in 2019, but it is still active. The development of an effective vaccine reduced the number of deaths; however, a treatment is still needed. Here, we aimed to inhibit viral entry to the host cell by inhibiting spike (S) pr
Externí odkaz:
https://doaj.org/article/3d2bcdca1a894e82a2a127126b2c31e2
Publikováno v:
Molecular Cancer Therapeutics. 21:1846-1856
Tumor protein p63 (TP63) is a member of the TP53 protein family that are important for development and in tumor suppression. Unlike TP53, TP63 is rarely mutated in cancer, but instead different TP63 isoforms regulate its activity. TA isoforms (TAp63)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba74173d46177414aa7fed030480297
https://doi.org/10.1158/1535-7163.mct-22-0008
https://doi.org/10.1158/1535-7163.mct-22-0008
Supplementary Data from Computational Modeling of TP63–TP53 Interaction and Rational Design of Inhibitors: Implications for Therapeutics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f1ab43e9e0a03ca134125c524cf387
https://doi.org/10.1158/1535-7163.22523334
https://doi.org/10.1158/1535-7163.22523334
How has artificial intelligence impacted COVID-19 drug repurposing and what lessons have we learned?
Publikováno v:
Expert opinion on drug discovery. 17(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57420ac0519fe29763610b1942635359
https://pubmed.ncbi.nlm.nih.gov/36154343
https://pubmed.ncbi.nlm.nih.gov/36154343
Publikováno v:
Genes. 13(2)
Formation of Ras multimers, including dimers and nanoclusters, has emerged as an exciting, new front of research in the ‘old’ field of Ras biomedicine. With significant advances made in the past few years, we are beginning to understand the struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5e03e214dfc2f85e8aded55e272022
https://pubmed.ncbi.nlm.nih.gov/35205266
https://pubmed.ncbi.nlm.nih.gov/35205266
Publikováno v:
Current Opinion in Structural Biology. 56:11-17
Proteins are dynamic, and this holds especially for their surfaces. They display ensembles of conformations, which allows them to interact with diverse partners, often via the same patch of surface, and execute their distinct functions. Binding a spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505cc9304e7480795b20d0eeda86402a
https://doi.org/10.1016/j.sbi.2018.10.007
https://doi.org/10.1016/j.sbi.2018.10.007
Publikováno v:
Cancer Research. 82:3358-3358
p63 plays a central role in limb formation and epithelial differentiation. p63, reported to correlate with cancer formation, is rarely mutated in cancers. Different p63 isoforms can have anti-tumorigenic or pro-tumorigenic activity. TA isoforms act a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8925384c437241785e84beb5da19d5cc
https://doi.org/10.1158/1538-7445.am2022-3358
https://doi.org/10.1158/1538-7445.am2022-3358
Autor:
Hyunbum Jang, Chung-Jung Tsai, Ozlem Keskin, Ezgi Odabasi, Ibrahim Halil Kavakli, Attila Gursoy, Ruth Nussinov, Elif Nur Firat-Karalar, E. Sila Ozdemir, Cihan Aydin, Serena Muratcioglu
Publikováno v:
J Mol Biol
Ras recruits and activates effectors that transmit receptor-initiated signals. Monomeric Ras can bind Raf; however, Raf's activation requires dimerization, which can be facilitated by Ras dimerization. Previously, we showed that active K-Ras4B dimeri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d05f67a46e88285b941927b69c204b9
https://aperta.ulakbim.gov.tr/record/8711
https://aperta.ulakbim.gov.tr/record/8711