Gene delivery corrects N-acetylglutamate synthase deficiency and enables insights in the physiological impact of L-arginine activation of N-acetylglutamate synthase

Autor: P. Sonaimuthu, E. Senkevitch, N. Haskins, P. Uapinyoying, M. McNutt, H. Morizono, M. Tuchman, L. Caldovic

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)

Abstract The urea cycle protects the central nervous system from ammonia toxicity by converting ammonia to urea. N-acetylglutamate synthase (NAGS) catalyzes formation of N-acetylglutamate, an essential allosteric activator of carbamylphosphate synthe

Externí odkaz: https://doaj.org/article/3cb4d09c378b4a00b4053cca1e4add5d

Urolithin A Hijacks ERK1/2‐ULK1 Cascade to Improve CD8⁺ T Cell Fitness for Antitumor Immunity.

Autor: Ma, Shuaiya¹ (AUTHOR), Wu, Qi² (AUTHOR), Wu, Wenxian^1,3,4 (AUTHOR), Tian, Ye¹ (AUTHOR), Zhang, Jie⁵ (AUTHOR), Chen, Chaojia¹ (AUTHOR), Sheng, Xue¹ (AUTHOR), Zhao, Fangcheng¹ (AUTHOR), Ding, Lu¹ (AUTHOR), Wang, Taixia⁶ (AUTHOR), Zhao, Laixi¹ (AUTHOR), Xie, Yuying³ (AUTHOR), Wang, Yongxiang³ (AUTHOR), Yue, Xuetian⁷ (AUTHOR), Wu, Zhuanchang¹ (AUTHOR), Wei, Jian⁸ (AUTHOR), Zhang, Kun⁶ (AUTHOR), Liang, Xiaohong¹ (AUTHOR), Gao, Lifen¹ (AUTHOR), Wang, Hongyan⁹ (AUTHOR)

Publikováno v: Advanced Science. May2024, Vol. 11 Issue 18, p1-19. 19p.

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Targeting Glutamine Metabolism to Enhance Immunoprevention of EGFR‐Driven Lung Cancer.

Autor: Huang, Mofei¹ (AUTHOR), Xiong, Donghai¹ (AUTHOR), Pan, Jing¹ (AUTHOR), Zhang, Qi¹ (AUTHOR), Sei, Shizuko² (AUTHOR), Shoemaker, Robert H.² (AUTHOR), Lubet, Ronald A.² (AUTHOR), Montuenga, Luis M.^3,4,5,6 (AUTHOR), Wang, Yian¹ (AUTHOR), Slusher, Barbara S.^7,8 (AUTHOR), You, Ming¹ (AUTHOR) myou@houstonmethodist.org

Publikováno v: Advanced Science. Sep2022, Vol. 9 Issue 26, p1-18. 18p.