Zobrazeno 1 - 10
of 526
pro vyhledávání: '"E. Sears"'
Autor:
Elliot H. Choi, Susie Suh, Avery E. Sears, Rafał Hołubowicz, Sanjay R. Kedhar, Andrew W. Browne, Krzysztof Palczewski
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 8, Pp 1678-1690 (2023)
Abstract Genome-editing technologies have ushered in a new era in gene therapy, providing novel therapeutic strategies for a wide range of diseases, including both genetic and nongenetic ocular diseases. These technologies offer new hope for patients
Externí odkaz:
https://doaj.org/article/d58bc19db29b4a7e9532ad192a5f1a3b
Autor:
Alexa Sadier, Neal Anthwal, Andrew L. Krause, Renaud Dessalles, Michael Lake, Laurent A. Bentolila, Robert Haase, Natalie A. Nieves, Sharlene E. Santana, Karen E. Sears
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Tooth classes are an innovation that has contributed to the evolutionary success of mammals. However, our understanding of the mechanisms by which tooth classes diversified remain limited. We use the evolutionary radiation of noctilionoid ba
Externí odkaz:
https://doaj.org/article/f09515d3e8264921b6934e659a66b829
Autor:
Neal Anthwal, Daniel J. Urban, Alexa Sadier, Risa Takenaka, Simon Spiro, Nancy Simmons, Richard R. Behringer, Chris J. Cretekos, John J. Rasweiler, Karen E. Sears
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Through the evolution of novel wing structures, bats (Order Chiroptera) became the only mammalian group to achieve powered flight. This achievement preceded the massive adaptive radiation of bats into diverse ecological niches. We
Externí odkaz:
https://doaj.org/article/2772d3e2aedb4863ba2e22bd960da368
Autor:
Victoria J Sugrue, Joseph Alan Zoller, Pritika Narayan, Ake T Lu, Oscar J Ortega-Recalde, Matthew J Grant, C Simon Bawden, Skye R Rudiger, Amin Haghani, Donna M Bond, Reuben R Hore, Michael Garratt, Karen E Sears, Nan Wang, Xiangdong William Yang, Russell G Snell, Timothy A Hore, Steve Horvath
Publikováno v:
eLife, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/3a91ff2b152a430ebb04aa6413d17d2f
Autor:
Pamela F. Weiss, Cora E. Sears, Timothy G. Brandon, Christopher B. Forrest, Emily Neu, Melanie Kohlheim, Jenny Leal, Rui Xiao, Daniel Lovell
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background The effectiveness of biologic therapies, primarily tumor necrosis factor inhibitors (TNFi), for children with spondyloarthritis (SpA) has made inactive disease a realistic patient outcome. However, biologic therapies are costly, p
Externí odkaz:
https://doaj.org/article/d1702cf8534e4c1ebb23eaa08b57fc0c
Autor:
Steven D Imrisek, Matthew Lee, Dan Goldner, Harpreet Nagra, Lindsey M Lavaysse, Jamillah Hoy-Rosas, Jeff Dachis, Lindsay E Sears
Publikováno v:
JMIR Diabetes, Vol 7, Iss 2, p e34624 (2022)
BackgroundPersonalized feedback is an effective behavior change technique frequently incorporated into mobile health (mHealth) apps. Innovations in data science create opportunities for leveraging the wealth of user data accumulated by mHealth apps t
Externí odkaz:
https://doaj.org/article/f4105385cb234378b3ae6a49aecb651d
Autor:
Katie E. Sears, Keerthi Gullapalli, Divya Trivedi, Alexander Mihas, Michael A. Bukys, Jan Jensen
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104133- (2022)
Summary: Successful manufacture of specialized human cells requires process understanding of directed differentiation. Here, we apply high-dimensional Design of Experiments (HD-DoE) methodology to identify critical process parameters (CPPs) that gove
Externí odkaz:
https://doaj.org/article/99c661bf3bef4aff957a35284d2f3ab6
Autor:
Charandeep Singh, Vincent Tran, Leah McCollum, Youstina Bolok, Kristin Allan, Alex Yuan, George Hoppe, Henri Brunengraber, Jonathan E. Sears
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Prematurely born babies need extra oxygen to survive, but this can cause damage to the eyes and lead to infant blindness. Here the authors show that this hyperoxia changes the metabolism of Müller cells in the retina such that they use up, rather th
Externí odkaz:
https://doaj.org/article/956377e5821140ba84212046f44f2ab9
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 37 (2022)
We asked whether hyperoxia might induce hypomyelination of the corpus callosum, clinically described as periventricular leukomalacia (PVL) of the severely preterm infant. Mouse pups and their nursing dams were placed in 80% oxygen from P4-P8, then re
Externí odkaz:
https://doaj.org/article/516e198bc24346d0b0ecfc2ee8abf5a9
Autor:
Victoria J Sugrue, Joseph Alan Zoller, Pritika Narayan, Ake T Lu, Oscar J Ortega-Recalde, Matthew J Grant, C Simon Bawden, Skye R Rudiger, Amin Haghani, Donna M Bond, Reuben R Hore, Michael Garratt, Karen E Sears, Nan Wang, Xiangdong William Yang, Russell G Snell, Timothy A Hore, Steve Horvath
Publikováno v:
eLife, Vol 10 (2021)
In mammals, females generally live longer than males. Nevertheless, the mechanisms underpinning sex-dependent longevity are currently unclear. Epigenetic clocks are powerful biological biomarkers capable of precisely estimating chronological age and
Externí odkaz:
https://doaj.org/article/901ed9d95cff4307a781c381e14cdfb3