Zobrazeno 1 - 10
of 325
pro vyhledávání: '"E. Schade"'
Autor:
Aaron M. Gruver, Haiyan Lu, Xiaoxian Zhao, Angie D. Fulford, Michael D. Soper, Darryl Ballard, Jeffrey C. Hanson, Andrew E. Schade, Eric D. Hsi, Klaus Gottlieb, Kelly M. Credille
Publikováno v:
Diagnostic Pathology, Vol 18, Iss 1, Pp 1-12 (2023)
Abstract Background Histologic evaluation of the mucosal changes associated with celiac disease is important for establishing an accurate diagnosis and monitoring the impact of investigational therapies. While the Marsh-Oberhuber classification has b
Externí odkaz:
https://doaj.org/article/77800cfdc1234688b422c739cee2d36c
Autor:
Francesca Nardi, Naiara Perurena, Amy E. Schade, Ze-Hua Li, Kenneth Ngo, Elena V. Ivanova, Aisha Saldanha, Chendi Li, Prafulla C. Gokhale, Aaron N. Hata, David A. Barbie, Cloud P. Paweletz, Pasi A. Jänne, Karen Cichowski
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 16 (2023)
Despite the success of KRAS G12C inhibitors in non–small cell lung cancer (NSCLC), more effective treatments are needed. One preclinical strategy has been to cotarget RAS and mTOR pathways; however, toxicity due to broad mTOR inhibition has limited
Externí odkaz:
https://doaj.org/article/755ab4bb5edc4eaaa779ca594c91fcf4
Autor:
Amy E Schade, Ryan Kuzmickas, Carrie L Rodriguez, Kaia Mattioli, Miriam Enos, Alycia Gardner, Karen Cichowski
Publikováno v:
PLoS Biology, Vol 21, Iss 4, p e3002038 (2023)
While screening and early detection have reduced mortality from prostate cancer, castration-resistant disease (CRPC) is still incurable. Here, we report that combined EZH2/HDAC inhibitors potently kill CRPCs and cause dramatic tumor regression in agg
Externí odkaz:
https://doaj.org/article/cbbf2f8fe5bb48b684463c3b2ea4080e
Practicing Progress : The Promise and Limitations of Enlightenment. Festschrift for John A. McCarthy
Autor:
Richard E. Schade, Dieter Sevin
Practicing Progress focuses on the German Enlightenment in its dual manifestation as a cultural era and as a mode of discourse. The volume's unifying theme is the promise and limitations of the Enlightenment, as seen from the twenty-first century. Co
Publikováno v:
Trends in Biochemical Sciences. 47:1009-1022
Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB):E2F and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin-dependent kinase (CDK) phosphorylation of RB and DREAM allows for the expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d498e5b2073919b5021203e2452cf7
https://doi.org/10.1016/j.tibs.2022.06.007
https://doi.org/10.1016/j.tibs.2022.06.007
Autor:
Jong Wook Kim, Christian Berrios, Miju Kim, Amy E Schade, Guillaume Adelmant, Huwate Yeerna, Emily Damato, Amanda Balboni Iniguez, Laurence Florens, Michael P Washburn, Kim Stegmaier, Nathanael S Gray, Pablo Tamayo, Ole Gjoerup, Jarrod A Marto, James DeCaprio, William C Hahn
Publikováno v:
eLife, Vol 9 (2020)
Alterations involving serine-threonine phosphatase PP2A subunits occur in a range of human cancers, and partial loss of PP2A function contributes to cell transformation. Displacement of regulatory B subunits by the SV40 Small T antigen (ST) or mutati
Externí odkaz:
https://doaj.org/article/32430c98748f4c4397dd12a2a347b246
Autor:
David S. Hong, Ramon V. Tiu, Michael S. Gordon, Ilaria Conti, Karim A. Benhadji, Sheng-Bin Peng, James R. Henry, Michael D. Kaufman, Daniel L. Flynn, KrisAnne Crowe, Andrew E. Schade, Danni Yu, Melinda D. Willard, Amanda Sykes, Ling Gao, Wei Zhang, Michael J. Millward, Jordi Rodon Ahnert, Geoffrey I. Shapiro, Keith T. Flaherty, Antoine Hollebecque, Ryan J. Sullivan
Supplementary Figure S3 shows a heatmap of gene expression in the scale of log2 fold ratio between pre- and on-treatment tumor samples. The gene expression was obtained using the formula for a gene g: 2^[20-CT_g+HK]/1000 where CT is the cycle thresho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::577850f37d6a2a83b1ce6e248f301b3a
https://doi.org/10.1158/1535-7163.22521466
https://doi.org/10.1158/1535-7163.22521466
Autor:
Geoffrey I. Shapiro, Patrick Y. Wen, Keith T. Flaherty, Edward M. Chan, Damien M. Cronier, Martin Frenzel, Lily Q. Li, Palaniappan Kulanthaivel, Ricardo Martinez, Tuan S. Nguyen, Angie D. Fulford, Andrew E. Schade, Richard P. Beckmann, Aejaz Nasir, John F. Hilton, Drew W. Rasco, Muralidhar Beeram, Kyriakos P. Papadopoulos, Leena Gandhi, Jonathan W. Goldman, Anthony W. Tolcher, Sara M. Tolaney, Lee S. Rosen, Amita Patnaik
Supplementary Table 1. Summary of 33 Patients Treated with Abemaciclib in Dose Escalation. Supplementary Table 2. Baseline patient and disease characteristics. Supplementary Table 3. Possibly related treatment-emergent adverse events (>10% all grades
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36991b4fd4f6f7c7f083e22b6e2c0a5d
https://doi.org/10.1158/2159-8290.22531521
https://doi.org/10.1158/2159-8290.22531521
Autor:
Bianca, Frommer, Theresa, Folchert, Anna-Lena, Witschel, Mailin, Reddeker, Magdalena A R, Hauck, Nina, Anderle, Victoria S E, Schade, Laura, Zagami, Marielle, Rieks, Lutz, Wobbe, Andrea, Bräutigam, Marion, Eisenhut
Publikováno v:
Microbiology resource announcements.
Pseudomonas sp. strain MM223, Pseudomonas sp. strain MM227, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8b1f0d98cb622a95921e5c78bf7adbe2
https://pubmed.ncbi.nlm.nih.gov/36602347
https://pubmed.ncbi.nlm.nih.gov/36602347
Autor:
Bianca Frommer, Theresa Folchert, Anna-Lena Witschel, Mailin Reddeker, Magdalena A. R. Hauck, Nina Anderle, Victoria S. E. Schade, Laura Zagami, Marielle Rieks, Lutz Wobbe, Andrea Bräutigam, Marion Eisenhut
Pseudomonas sp. strain MM223, Pseudomonas sp. strain MM227, and Rheinheimera sp. strain MM224 were isolated from a muddy soil sample from the edge of a pond. Here, we present whole-genome sequences and phylogenetic classifications for all three bacte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8aba4cead80ed307f698ccac1aa216
https://pub.uni-bielefeld.de/record/2967990
https://pub.uni-bielefeld.de/record/2967990