Zobrazeno 1 - 10
of 391
pro vyhledávání: '"E. Sanders‐Bush"'
Autor:
Harel Weinstein, R Seifert, Juan A. Ballesteros, Ulrik Gether, E Sanders-Bush, Brian K. Kobilka
Publikováno v:
Journal of Biological Chemistry. 272:2587-2590
Mutations in several domains can lead to agonist-independent, constitutive activation of G protein-coupled receptors. However, the nature of the structural and molecular changes that constitutively turn on a G protein-coupled receptor remains unknown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dada5ece70ac029b88c5cc0595dfa970
https://doi.org/10.1074/jbc.272.5.2587
https://doi.org/10.1074/jbc.272.5.2587
Autor:
R, Ye, A M D, Carneiro, Q, Han, D, Airey, E, Sanders-Bush, B, Zhang, L, Lu, R, Williams, R D, Blakely
Publikováno v:
Genes, brain, and behavior. 13(3)
Presynaptic serotonin (5-hydroxytryptamine, 5-HT) transporters (SERT) regulate 5-HT signaling via antidepressant-sensitive clearance of released neurotransmitter. Polymorphisms in the human SERT gene (SLC6A4) have been linked to risk for multiple neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f6d9d6f0c2811d2025aec6760813e7d2
https://pubmed.ncbi.nlm.nih.gov/24405699
https://pubmed.ncbi.nlm.nih.gov/24405699
Autor:
E. Sanders‐Bush, David L. Nelson, Steve R. Waldman, Danuta Marona-Lewicka, David E. Nichols, Aaron Monte, D. B. Wainscott
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6b99687e14e904cdc72b2250902a42c
https://doi.org/10.1002/chin.199801111
https://doi.org/10.1002/chin.199801111
Publikováno v:
British journal of pharmacology. 134(2)
1. The serotonin(2C) (5-HT(2C)) receptor couples to both phospholipase C (PLC)-inositol phosphate (IP) and phospholipase A(2) (PLA(2))-arachidonic acid (AA) signalling cascades. Agonists can differentially activate these effectors (i.e. agonist-direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::550996b2c9fb65c806b229bc884456bf
https://pubmed.ncbi.nlm.nih.gov/11564657
https://pubmed.ncbi.nlm.nih.gov/11564657
Publikováno v:
Synapse (New York, N.Y.). 39(4)
Treatment with conventional antipsychotic drugs (APDs) is accompanied by extrapyramidal side effects (EPS), which are thought to be due to striatal dopamine D(2) receptor blockade. In contrast, treatment with atypical APDs is marked by a low incidenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d8f5732e8f7f341c8dc8734cbe82843c
https://pubmed.ncbi.nlm.nih.gov/11169779
https://pubmed.ncbi.nlm.nih.gov/11169779
Publikováno v:
The Journal of biological chemistry. 275(10)
To determine the intracellular signaling mechanism of the 5-HT(2C) receptor endogenously expressed in choroid plexus epithelial cells, we implemented a strategy of targeted disruption of protein-protein interactions. This strategy entails the deliver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f080673fbb0457a04b8ab9910da4512f
https://pubmed.ncbi.nlm.nih.gov/10702266
https://pubmed.ncbi.nlm.nih.gov/10702266
Publikováno v:
The Journal of biological chemistry. 273(9)
The beta2-adrenoreceptor (beta2AR) couples to the G-protein Gs to mediate adenylyl cyclase activation. The splice variants of Gs alpha differ by a 15-amino acid insert between the Ras-like domain and the alpha-helical domain. The long splice variant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::85b7f51cb56d98702e24b75594d24f8a
https://pubmed.ncbi.nlm.nih.gov/9478963
https://pubmed.ncbi.nlm.nih.gov/9478963
Publikováno v:
The Journal of biological chemistry. 272(5)
Mutations in several domains can lead to agonist-independent, constitutive activation of G protein-coupled receptors. However, the nature of the structural and molecular changes that constitutively turn on a G protein-coupled receptor remains unknown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cdecd7f1b0a436c610caf49f201c7540
https://pubmed.ncbi.nlm.nih.gov/9006889
https://pubmed.ncbi.nlm.nih.gov/9006889
Publikováno v:
Molecular pharmacology. 50(4)
The actions of the neurotransmitter 5-hydroxytryptamine (5-HT) (serotonin) are mediated by multiple receptor subtypes. One of the prominent serotonin receptors in the brain is the 5-HT2C receptor (5-HT2C-R). We report the occurrence of a second 5-HT2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::67e1d767492e54eb37fd74ec677792c2
https://pubmed.ncbi.nlm.nih.gov/8863824
https://pubmed.ncbi.nlm.nih.gov/8863824
Autor:
R S, Westphal, E, Sanders-Bush
Publikováno v:
Molecular pharmacology. 49(3)
Previous studies have shown that agonist activation of the 5-hydroxytryptamineC (5-HT2C) receptor expressed in NIH-3T3 fibroblasts results in development of a transformed phenotype. In light of recent evidence from our laboratory demonstrating consti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::785d6d897f7a97dd4e85325a51b0d7a3
https://pubmed.ncbi.nlm.nih.gov/8643087
https://pubmed.ncbi.nlm.nih.gov/8643087