Výsledky vyhledávání - "E. S. Starodubova"

Akademický článek

Codon optimization and improved delivery/immunization regimen enhance the immune response against wild-type and drug-resistant HIV-1 reverse transcriptase, preserving its Th2-polarity

Autor: A. A. Latanova, S. Petkov, A. Kilpelainen, J. Jansons, O. E. Latyshev, Y. V. Kuzmenko, J. Hinkula, M. A. Abakumov, V. T. Valuev-Elliston, M. Gomelsky, V. L. Karpov, F. Chiodi, B. Wahren, D. Y. Logunov, E. S. Starodubova, M. G. Isaguliants

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-22 (2018)

Abstract DNA vaccines require a considerable enhancement of immunogenicity. Here, we optimized a prototype DNA vaccine against drug-resistant HIV-1 based on a weak Th2-immunogen, HIV-1 reverse transcriptase (RT). We designed expression-optimized gene

Externí odkaz: https://doaj.org/article/1b38b6e3c64d4d089d2e1bc152026848

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Akademický článek

Luciferase Expression Allows Bioluminescence Imaging But Imposes Limitations on the Orthotopic Mouse (4T1) Model of Breast Cancer

Autor: V. P. Baklaushev, A. Kilpeläinen, S. Petkov, M. A. Abakumov, N. F. Grinenko, G. M. Yusubalieva, A. A. Latanova, I. L. Gubskiy, F. G. Zabozlaev, E. S. Starodubova, T. O. Abakumova, M. G. Isaguliants, V. P. Chekhonin

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)

Abstract Implantation of reporter-labeled tumor cells in an immunocompetent host involves a risk of their immune elimination. We have studied this effect in a mouse model of breast cancer after the orthotopic implantation of mammary gland adenocarcin

Externí odkaz: https://doaj.org/article/1e8e0eebf76b4e3cbb74e7a11e8b17f1

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C-terminal lysosome targeting domain of CD63 modifies cellular localization of rabies virus glycoprotein

Autor: Vadim L. Karpov, Y. V. Kuzmenko, O. V. Preobrazhenskaya, A. A. Latanova, E. S. Starodubova

Publikováno v: Molecular Biology. 51:404-407

The glycoprotein of rabies virus is the central antigen elicited the immune response to infection; therefore, the majority of developing anti-rabies vaccines are based on this protein. In order to increase the efficacy of DNA immunogen encoding rabie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0970fe5b526c33717ca377ddb40b1a9c
https://doi.org/10.1134/s0026893317020200

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Rabies Virus Glycoprotein with a Consensus Amino Acid Sequence and a Lysosome Targeting Signal Causes Effective Production of Antibodies in DNA-Immunized Mice

Autor: Vadim L. Karpov, A. A. Latanova, E. O. Pankova, O. V. Preobrazhenskaya, Y. V. Kuzmenko, E. S. Starodubova

Publikováno v: Molecular Biology. 52:269-271

Safe and effective anti-rabies vaccines are intensely sought worldwide. DNA vaccines have already shown their efficacy and safety and have occupied a special place in the field. Two prototype anti-rabies DNA vaccines were compared for the potential t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3c4c221c05bbef48b533478fd8a1d4f
https://doi.org/10.1134/s0026893318020164

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Creation of DNA vaccine vector based on codon-optimized gene of rabies virus glycoprotein (G protein) with consensus amino acid sequence

Autor: E. S. Starodubova, A. A. Latanova, Y. V. Kuzmenko, Vadim L. Karpov, O. V. Preobrazhenskaya

Publikováno v: Molecular Biology. 50:328-331

An optimized design of the rabies virus glycoprotein (G protein) for use within DNA vaccines has been suggested. The design represents a territorially adapted antigen constructed taking into account glycoprotein amino acid sequences of the rabies vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a241479741018e0889c2104cd3926d9d
https://doi.org/10.1134/s0026893316020242

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Nonstructural protein 1 of tick-borne encephalitis virus activates the expression of immunoproteasome subunits

Autor: Galina G. Karganova, Y. V. Kuzmenko, Vadim L. Karpov, E. S. Starodubova, A. V. Timofeev

Publikováno v: Molecular Biology. 50:307-312

The interaction of viral proteins with host cell components plays an important role in antiviral immune response. One of the key steps of antiviral defense is the formation of immunoproteasomes. The effect of nonstructural protein 1 (NS1) of tick-bor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ca60e5c59b5ef84fe54a8f8b1ee7f15
https://doi.org/10.1134/s0026893316020126

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Codon optimization and improved delivery/immunization regimen enhance the immune response against wild-type and drug-resistant HIV-1 reverse transcriptase, preserving its Th2-polarity

Autor: Denis Y. Logunov, Jorma Hinkula, Francesca Chiodi, Maria G. Isaguliants, Maxim A. Abakumov, A. A. Latanova, Oleg Latyshev, Vladimir T. Valuev-Elliston, Mark Gomelsky, Yulia Kuzmenko, Britta Wahren, Athina Kilpelainen, Stefan Petkov, Vadim L. Karpov, E. S. Starodubova, Juris Jansons

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-22 (2018)

DNA vaccines require a considerable enhancement of immunogenicity. Here, we optimized a prototype DNA vaccine against drug-resistant HIV-1 based on a weak Th2-immunogen, HIV-1 reverse transcriptase (RT). We designed expression-optimized genes encodin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30fe3ea7a2740af9b6d7a12b83a72431
https://zenodo.org/record/2706482

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