Zobrazeno 1 - 10 of 377 pro vyhledávání: '"E. S. Soliman"'
3
Akademický článek
Repurposing of drug candidates against Epstein-Barr virus: Virtual screening, docking computations, molecular dynamics, and quantum mechanical study.
Autor: Mahmoud A A Ibrahim, Alaa M A Hassan, Eslam A R Mohamed, Gamal A H Mekhemer, Peter A Sidhom, Mohamed A El-Tayeb, Shahzeb Khan, Tamer Shoeib, Mahmoud E S Soliman, Alaa H M Abdelrahman
Publikováno v: PLoS ONE, Vol 19, Iss 11, p e0312100 (2024)
Epstein-Barr virus (EBV) was the first tumor virus identified in humans, and it is mostly linked to lymphomas and cancers of epithelial cells. Nevertheless, there is no FDA-licensed drug feasible for this ubiquitous EBV viral contagion. EBNA1 (Epstei
Externí odkaz: https://doaj.org/article/38693de6b7d9468396b75241ea858769
Zobrazit plný text záznamu
4
Akademický článek
Novel Sunifiram-carbamate hybrids as potential dual acetylcholinesterase inhibitor and NMDAR co-agonist: simulation-guided analogue design and pharmacological screening
Autor: Khalid A. Agha, Nader E. Abo-Dya, Abdul Rashid Issahaku, Clement Agoni, Mahmoud E. S. Soliman, Eatedal H. Abdel-Aal, Zakaria K. Abdel-Samii, Tarek S. Ibrahim
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1241-1256 (2022)
An efficient method for synthesising NMDAR co-agonist Sunifiram (DM235), in addition to Sunifram-carbamate and anthranilamide hybrids, has been developed in high yields via protecting group-free stepwise unsymmetric diacylation of piperazine using N-
Externí odkaz: https://doaj.org/article/4e635989cfea448eab1877e1019864be
Zobrazit plný text záznamu
8
Akademický článek
The Unusual Architecture of RNA-Dependent RNA Polymerase (RdRp)’s Catalytic Chamber Provides a Potential Strategy for Combination Therapy against COVID-19
Autor: Kamel Metwally, Nader E. Abo-Dya, Mohammed Issa Alahmdi, Maha Z. Albalawi, Galal Yahya, Aimen Aljoundi, Elliasu Y. Salifu, Ghazi Elamin, Mahmoud A. A. Ibrahim, Yasien Sayed, Sylvia Fanucchi, Mahmoud E. S. Soliman
Publikováno v: Molecules, Vol 28, Iss 6, p 2806 (2023)
The unusual and interesting architecture of the catalytic chamber of the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) was recently explored using Cryogenic Electron Microscopy (Cryo-EM), which revealed the presence of two distinctive binding caviti
Externí odkaz: https://doaj.org/article/a3686c20460b45f7b706fbd4b5d44f8d
Zobrazit plný text záznamu
9
Akademický článek
Artificial Intelligence, Machine Learning, and Big Data for Ebola Virus Drug Discovery
Autor: Samuel K. Kwofie, Joseph Adams, Emmanuel Broni, Kweku S. Enninful, Clement Agoni, Mahmoud E. S. Soliman, Michael D. Wilson
Publikováno v: Pharmaceuticals, Vol 16, Iss 3, p 332 (2023)
The effect of Ebola virus disease (EVD) is fatal and devastating, necessitating several efforts to identify potent biotherapeutic molecules. This review seeks to provide perspectives on complementing existing work on Ebola virus (EBOV) by discussing
Externí odkaz: https://doaj.org/article/8012805661244f51a4e443eb0705e0eb
Zobrazit plný text záznamu
10
Akademický článek
Chetomin, a SARS-CoV-2 3C-like Protease (3CLpro) Inhibitor: In Silico Screening, Enzyme Docking, Molecular Dynamics and Pharmacokinetics Analysis
Autor: Mahmoud A. A. Ibrahim, Alaa H. M. Abdelrahman, Dina E. M. Mohamed, Khlood A. A. Abdeljawaad, Mohamed Ahmed Naeem, Gamal A. Gabr, Ahmed M. Shawky, Mahmoud E. S. Soliman, Peter A. Sidhom, Paul W. Paré, Mohamed-Elamir F. Hegazy
Publikováno v: Viruses, Vol 15, Iss 1, p 250 (2023)
The emergence of the Coronavirus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to over 6 million deaths. The 3C-like protease (3CLpro) enzyme of the SARS-CoV-2 virus is an attractive d
Externí odkaz: https://doaj.org/article/9b889d0689364673945ed2c575f1957b
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje