Zobrazeno 1 - 10
of 23
pro vyhledávání: '"E. S. C. Wu"'
Publikováno v:
Drug Discovery Today. 2:341-350
Years of clinical research to treat disorders such as peptic ulcers and obstructive lung disease with the first generation of modestly selective M1 antagonists (e.g. pirenzepine, telenzepine) have been disappointing. For some indications (chronic obs
Autor:
Sally A. McCreedy, Kris E. Kucera, David J. Triggle, Matthew Marler, Roberta Mihut, E. S. C. Wu, Jack Gordon, Mary L. Stagnitto, Dan Widzowski, Andrew Howell, Anthony C. Machulskis, John Zongrone, Paul Bialobok, George B. Mullen, Marilyn K. Knowles, Shawn Sitar, James C. Blosser
Publikováno v:
Drug Development Research. 40:117-132
The purpose of these studies was to determine the levels of intrinsic activity in vitro at muscarinic receptor pharmacological subtypes (M1, M2, and M3) that would optimize cognitive activity while minimizing acute adverse cholinergic effects in vivo
Autor:
Alex Kover, Robert J. Murray, James C. Blosser, R. A. Mack, George B. Mullen, Sally A. McCreedy, James T. Loch, Anthony C. Machulskis, E. S. C. Wu, John C. Gordon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1813-1818
A short and efficient synthesis of both enantiomers of 2,8-dimethyl-1-oxa-8-azaspiro[4.5]-decan-3-one is described. The biological activity of the racemate resides predominantly in the S-enantiomer. While the S-isomer is a full M2-agonist, the R-isom
Publikováno v:
The Journal of Organic Chemistry. 58:6158-6162
Autor:
E. S. C. Wu, A. Kover
Publikováno v:
ChemInform. 24
Publikováno v:
ChemInform. 25
Autor:
James T. Loch, Robert J. Murray, James C. Blosser, Sally A. McCreedy, E. S. C. Wu, R. A. Mack, Anthony C. Machulskis, George B. Mullen, John C. Gordon, Alexander Rochester New York Us Kover
Publikováno v:
ChemInform. 26
Publikováno v:
Journal of medicinal chemistry. 41(22)
Autor:
E. S. C. Wu, E. Vedejs
Publikováno v:
Journal of the American Chemical Society. 97:4706-4713
Autor:
M. A. Dailey, T. L. Thomas, T. A. Davidson, T. E. Cole, A. R. Borrelli, M. Fedorchuk, E. S. C. Wu, James C. Blosser, K. G. Doring, J T Loch rd
Publikováno v:
Journal of Medicinal Chemistry. 32:183-192
(3-Phenyl-7-flavonoxy)propanolamines have been shown to exhibit antihypertensive activity in spontaneously hypertensive rats. Although they are structurally similar to classical beta-adrenergic blocking compounds, their activity is not due to inhibit