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Autor:
M. Yamada, E. Richelson
Publikováno v:
Neuroscience. 64:405-417
We have recently cloned the neurotensin receptor from human substantia nigra. Usingin situ hybridization techniques, with an35S-labeled antisense RNA probe complementary to this receptor complementary DNA, we studied the expression of the human neuro
Autor:
B. Cusack, E. Richelson
Publikováno v:
Journal of Receptor Research. 13:123-134
Radioligand binding assays provide a powerful tool for screening drug candidates at many receptors. We present a method utilizing a robotic workstation, the Biomek 1000, which automates the tedious and repetitive tasks of these assays. First, the rob
Autor:
E, Richelson
Publikováno v:
Current opinion in investigational drugs (London, England : 2000). 2(2)
Autor:
B M, Tyler-McMahon, J A, Stewart, J, Jackson, M D, Bitner, A, Fauq, D J, McCormick, E, Richelson
Publikováno v:
Biochemical pharmacology. 62(7)
The dopamine transporter (DAT) plays a role in locomotion and is an obligatory target for amphetamines. We designed and synthesized an antisense peptide nucleic acid (PNA) to rat DAT to examine the effect of this antisense molecule on locomotion and
Autor:
E, Richelson, T, Souder
Publikováno v:
Life sciences. 68(1)
Using radioligand binding assays and post-mortem normal human brain tissue, we obtained equilibrium dissociation constants (K(d)s) for nine new antipsychotic drugs (iloperidone, melperone, olanzapine, ORG 5222, quetiapine, risperidone, sertindole, zi
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 55(1)
We have developed a neurotensin analog, L-[3,1'-naphthylalanine11]NT(8-13), NT34, that can distinguish between rat and human neurotensin receptors, and exhibits more than a 100-fold difference in binding affinities and a 60-fold difference in functio
Autor:
E, Richelson
Publikováno v:
The Journal of clinical psychiatry. 60
This article reviews the receptor pharmacology of neuroleptics, with a focus on newer drugs (e.g., risperidone, olanzapine, sertindole, quetiapine, and ziprasidone) in contrast to older compounds. All these newer compounds are considered to be atypic
Autor:
E, Richelson
Publikováno v:
The Journal of clinical psychiatry. 59
Seven of the newest antidepressants are the serotonin selective reuptake inhibitors (fluoxetine, sertraline, paroxetine, and fluvoxamine [currently approved in the United States for obsessive-compulsive disorder only]), a serotonin norepinephrine reu
Publikováno v:
Seminars in oncology. 25(1 Suppl 1)
The central nervous system side effects associated with interferon-alpha (IFN-alpha) therapy, including depression and cognitive changes, can compromise otherwise effective immunotherapy. The term "depression" has multiple meanings ranging from a fee