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Chronic Embryo-Larval Exposure of Fathead Minnows to the Pharmaceutical Drug Metformin: Survival, Growth, and Microbiome Responses

Autor: Hufsa Khan, Victoria E. Restivo, Joanne L. Parrott, Stacey Clarence, Karen A. Kidd, Grazina Pacepavicius, Kallie Shires, Mehran Alaee, Cheryl Sullivan, Juliet Zhu

Publikováno v: Environmental toxicology and chemistry. 41(3)

Metformin is a glucose-lowering drug commonly found in municipal wastewater effluents (MWWEs). The present study investigated the chronic effects of metformin in early-life stages of the fathead minnow (Pimephales promelas). Endpoints assessed were g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df66c1fcb25d0809995feb775e810810
https://pubmed.ncbi.nlm.nih.gov/33788292

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Rainbow darter (Etheostoma caeruleum) from a river impacted by municipal wastewater effluents have altered gut content microbiomes

Autor: Michael G. Surette, Karen A. Kidd, Mark R. Servos, Victoria E. Restivo, Joanna Y. Wilson

Publikováno v: The Science of the total environment. 751

Municipal wastewater treatment plant (WWTP) effluent contains pharmaceuticals and personal care products known to affect fish health and reproduction. The microbiome is a community of bacteria integral in maintaining host health and is influenced by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6cc0f248900a78129a1b9f5fcb39705
https://pubmed.ncbi.nlm.nih.gov/32889463

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Gestational triphenyl phosphate exposure in C57Bl/6 mice perturbs expression of insulin-like growth factor signaling genes in maternal and fetal liver

Autor: Louise M. Winn, Christine L. Belanger, Nicola A. Philbrook, Victoria E. Restivo

Publikováno v: Birth Defects Research. 110:483-494

Triphenyl phosphate (TPhP) is an organophosphorus flame retardant and plasticizer that has been added to numerous consumer products in recent years. TPhP is not overtly toxic, however recent studies have suggested that it may have metabolic disruptin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3a4e1467388ae6db396315c69a4e96
https://doi.org/10.1002/bdr2.1185

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The gut content microbiome of wild-caught rainbow darter is altered during laboratory acclimation

Autor: Victoria E. Restivo, Karen A. Kidd, Joanna Y. Wilson, Michael G. Surette, Carol Bucking

Publikováno v: Comparative Biochemistry and Physiology Part D: Genomics and Proteomics. 39:100835

An increasing number of laboratory studies are showing that environmental stressors and diet affect the fish gut microbiome. However, the application of these results to wild populations is uncertain as little is known about how the gut microbiome sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8902bdc1b9033eaaadd16ae726c264ea
https://doi.org/10.1016/j.cbd.2021.100835

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Diabetes induces stable intrinsic changes to myeloid cells that contribute to chronic inflammation during wound healing in mice

Autor: Sally Wood, Laura Campbell, Terry E. Restivo, Pauline Bannon, Kimberly A. Mace, Matthew J. Hardman

Publikováno v: Disease Models & Mechanisms, Vol 6, Iss 6, Pp 1434-1447 (2013)
Disease Models & Mechanisms

Summary Acute inflammation in response to injury is a tightly regulated process by which subsets of leukocytes are recruited to the injured tissue and undergo behavioural changes that are essential for effective tissue repair and regeneration. The di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e2750c77fe5801954010f43709aafc
http://dmm.biologists.org/content/6/6/1434

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Application of the Chemokine CXCL12 Expression Plasmid Restores Wound Healing to Near Normal in a Diabetic Mouse Model

Autor: Kimberly A. Mace, Alden H. Harken, David M. Young, Terry E. Restivo

Publikováno v: Journal of Trauma: Injury, Infection & Critical Care. 69:392-398

Background: CXCL12 is a chemokine involved in postinjury leukocyte chemotaxis, migration, and homing of stem cells. We hypothesized that by increasing the level of the chemokine CXCL12 in wounds of diabetic mice, we would increase stem cell recruitme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e034cb8f6c5c484df59dbe9d9d6c26
https://doi.org/10.1097/ta.0b013e3181e772b0

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