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Akademický článek

Periconceptional alcohol alters in vivo heart function in ageing female rat offspring: Possible involvement of oestrogen receptor signalling

Autor: Emily S. Dorey, John P. Headrick, Tamara M. Paravicini, Mary E. Wlodek, Karen M. Moritz, Melissa E. Reichelt

Publikováno v: Experimental Physiology, Vol 108, Iss 5, Pp 772-784 (2023)

Abstract Alcohol exposure throughout gestation is detrimental to cardiac development and function. Although many women decrease alcohol consumption once aware of a pregnancy, exposure prior to recognition is common. We, therefore, examined the effect

Externí odkaz: https://doaj.org/article/75fb20c7660847e0ae467adf56b99a92

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Akademický článek

Early cardiac aging linked to impaired stress-resistance and transcriptional control of stress response, quality control and mitochondrial pathways

Autor: Kevin J. Ashton, Can J. Kiessling, Jamie-Lee M. Thompson, Aliah Y. Aziz, Walter G. Thomas, John P. Headrick, Melissa E. Reichelt

Publikováno v: Experimental Gerontology, Vol 171, Iss , Pp 112011- (2023)

Phenotypic and transcriptomic evidence of early cardiac aging, and associated mechanisms, were investigated in young to middle-aged male mice (C57Bl/6; ages 8, 16, 32, 48 wks). Left ventricular gene expression (profiled via Illumina MouseWG-6 BeadChi

Externí odkaz: https://doaj.org/article/b99895f74fa84d758c457e5f9d5d22fc

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Akademický článek

WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis

Autor: Uda Y. Ho, Chun-Wei Allen Feng, Yvonne Y. Yeap, Amanda L. Bain, Zhe Wei, Belal Shohayeb, Melissa E. Reichelt, Hayden Homer, Kum Kum Khanna, Josephine Bowles, Dominic C. H. Ng

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)

Uda Ho et al find that loss of centriolar scaffold protein WDR62 in mouse testis leads to defects in spermatogenesis. They find that WDR62 deficiency leads to centriole underduplication in spermatocytes and delayed manchette removal in spermatids due

Externí odkaz: https://doaj.org/article/5fa87d30eabf4504b9c5fb5bd757b344

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Akademický článek

Type I Diabetes Mellitus Increases the Cardiovascular Complications of Influenza Virus Infection

Autor: Jane E. Sinclair, Conor J. Bloxham, Han Chiu, Keng Yih Chew, Jake Russell, Yusuke Yoshikawa, Helle Bielefeldt-Ohmann, Lauren E. Steele, Katina D. Hulme, Nathalie AJ. Verzele, Ellesandra C. Noye, Melanie Wu, Melissa E. Reichelt, Walter G. Thomas, Linda A. Gallo, Meredith A. Redd, Kirsty R. Short

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)

People with diabetes mellitus are susceptible to both cardiovascular disease and severe influenza A virus infection. We hypothesized that diabetes also increases risks of influenza-associated cardiac complications. A murine type 1 (streptozotocin-ind

Externí odkaz: https://doaj.org/article/a5d94dcaed7a4b54a8b0874e68cd9768

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Akademický článek

Sotagliflozin, a Dual SGLT1/2 Inhibitor, Improves Cardiac Outcomes in a Normoglycemic Mouse Model of Cardiac Pressure Overload

Autor: Sophia L. Young, Lydia Ryan, Thomas P. Mullins, Melanie Flint, Sarah E. Steane, Sarah L. Walton, Helle Bielefeldt-Ohmann, David A. Carter, Melissa E. Reichelt, Linda A. Gallo

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

Selective SGLT2 inhibition reduces the risk of worsening heart failure and cardiovascular death in patients with existing heart failure, irrespective of diabetic status. We aimed to investigate the effects of dual SGLT1/2 inhibition, using sotagliflo

Externí odkaz: https://doaj.org/article/3d8d2e4e85a44d89a8f35e1262506864

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Stimulation of the four isoforms of receptor tyrosine kinase ErbB4, but not ErbB1, confers cardiomyocyte hypertrophy

Autor: Brooke W. Purdue, Melissa E. Reichelt, David J. Pennisi, Enzo R. Porrello, Nicola J. Smith, Giovanna Gambarotta, Zhen Wang, Hsiu-Wen Chan, Shannon L. O'Brien, Walter G. Thomas, Tamara M. Paravicini

Publikováno v: Journal of Cellular Physiology. 236:8160-8170

Epidermal growth factor (EGF) receptors (ErbB1-ErbB4) promote cardiac development and growth, although the specific EGF ligands and receptor isoforms involved in growth/repair versus pathology remain undefined. We challenged ventricular cardiomyocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6fe3c5a27edc0ce52327a2899bf8a4e
https://doi.org/10.1002/jcp.30487

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Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury

Background: Ischemia–reperfusion injury (IRI) is one of the major risk factors implicated in morbidity and mortality associated with cardiovascular disease. During cardiac ischemia, the buildup of acidic metabolites results in decreased intracellul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a87355930a63d2e18ca69d4c7ecfae
https://hdl.handle.net/10453/151624

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Akademický článek

RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility.

Autor: Ze-Yan Yu, Ju-Chiat Tan, Aisling C McMahon, Siiri E Iismaa, Xiao-Hui Xiao, Scott H Kesteven, Melissa E Reichelt, Marion C Mohl, Nicola J Smith, Diane Fatkin, David Allen, Stewart I Head, Robert M Graham, Michael P Feneley

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e99024 (2014)

To determine the mechanisms by which the α1A-adrenergic receptor (AR) regulates cardiac contractility.We reported previously that transgenic mice with cardiac-restricted α1A-AR overexpression (α1A-TG) exhibit enhanced contractility but not hypertr

Externí odkaz: https://doaj.org/article/7cf2975340e84d309efedf580a689349

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