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Engineering an inducible leukemia-associated fusion protein enables large-scale ex vivo production of functional human phagocytes.

Autor: Windisch R; Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany., Soliman S; Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany., Hoffmann A; Vascular Biology, Institute for Stroke and Dementia Research, Ludwig-Maximilians-Universität München, Munich 81377, Germany.; Department of Anesthesiology, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany., Chen-Wichmann L; Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany., Danese A; Biomedical Center, Department of Physiological Genomics, Ludwig-Maximilians-Universität München, Munich 81377, Germany., Vosberg S; Department of Medicine III, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany.; German Cancer Consortium, Partner site Munich, Munich 81377, Germany.; German Cancer Research Center, Heidelberg 69120, Germany.; Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz 8010, Austria., Bravo J; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main 60596, Germany., Lutz S; Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany., Kellner C; Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany., Fischer A; Department of Internal Medicine III, University Hospital Regensburg, Regensburg 93053, Germany., Gebhard C; Leibniz Institute for Immunotherapy, Regensburg 93053, Germany., Redondo Monte E; Department of Medicine III, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany.; German Cancer Consortium, Partner site Munich, Munich 81377, Germany.; German Cancer Research Center, Heidelberg 69120, Germany., Hartmann L; Department of Medicine III, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany.; German Cancer Consortium, Partner site Munich, Munich 81377, Germany.; German Cancer Research Center, Heidelberg 69120, Germany., Schneider S; Department of Medicine III, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany.; Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany.; Institute of Human Genetics, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany., Beier F; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty University Hospital Aachen, Rheinisch-Westfälische Technische Hochschule Aachen, Aachen 52074, Germany., Strobl CD; Department of Medicine III, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany.; German Cancer Consortium, Partner site Munich, Munich 81377, Germany.; German Cancer Research Center, Heidelberg 69120, Germany., Weigert O; Department of Medicine III, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany.; German Cancer Consortium, Partner site Munich, Munich 81377, Germany.; German Cancer Research Center, Heidelberg 69120, Germany., Peipp M; Division of Antibody-Based Immunotherapy, Department of Medicine II, Christian Albrechts University of Kiel, Kiel 24105, Germany., Schündeln M; Pediatric Hematology and Oncology, Department of Pediatrics III, University Hospital Essen and the University of Duisburg-Essen, Essen 45147, Germany., Stricker SH; Biomedical Center, Department of Physiological Genomics, Ludwig-Maximilians-Universität München, Munich 81377, Germany., Rehli M; Department of Internal Medicine III, University Hospital Regensburg, Regensburg 93053, Germany.; Leibniz Institute for Immunotherapy, Regensburg 93053, Germany., Bernhagen J; Vascular Biology, Institute for Stroke and Dementia Research, Ludwig-Maximilians-Universität München, Munich 81377, Germany.; Munich Cluster for Systems Neurology, Munich 81377, Germany., Humpe A; Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany., Klump H; Institute for Transfusion Medicine, University Hospital Essen, Essen 45147, Germany.; Institute for Transfusion Medicine and Cell Therapeutics, University Hospital Aachen, Rheinisch-Westfälische Technische Hochschule Aachen, Aachen 52074, Germany., Brendel C; Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115., Krause DS; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main 60596, Germany.; Institute of General Pharmacology and Toxicology, University Hospital Frankfurt, Goethe-University, Frankfurt am Main 60596, Germany., Greif PA; Department of Medicine III, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany.; German Cancer Consortium, Partner site Munich, Munich 81377, Germany.; German Cancer Research Center, Heidelberg 69120, Germany., Wichmann C; Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jun 18; Vol. 121 (25), pp. e2312499121. Date of Electronic Publication: 2024 Jun 10.