Zobrazeno 1 - 10
of 517
pro vyhledávání: '"E. Rainey"'
Autor:
Kazutaka Nanba, Amy R. Blinder, Aaron M. Udager, Yuusuke Hirokawa, Takayoshi Miura, Hiroshi Okuno, Koki Moriyoshi, Yuto Yamazaki, Hironobu Sasano, Akihiro Yasoda, Noriko Satoh-Asahara, William E. Rainey, Tetsuya Tagami
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Double somatic mutations in CTNNB1 and GNA11/Q have recently been identified in a small subset of aldosterone-producing adenomas (APAs). As a possible pathogenesis of APA due to these mutations, an association with pregnancy, menopause, or puberty ha
Externí odkaz:
https://doaj.org/article/f946e9d2c19542a38c90af28d8ca3ed6
Autor:
Sharmilee Vetrivel, Mariangela Tamburello, Andrea Oßwald, Ru Zhang, Ali Khan, Sara Jung, Jessica E. Baker, William E. Rainey, Elisabeth Nowak, Barbara Altieri, Mario Detomas, Deepika Watts, Tracy Ann Williams, Ben Wielockx, Felix Beuschlein, Martin Reincke, Silviu Sbiera, Anna Riester
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundWe performed a transcriptomic analysis of adrenal signaling pathways in various forms of endogenous Cushing’s syndrome (CS) to define areas of dysregulated and druggable targets.MethodologyNext-generation sequencing was performed on adren
Externí odkaz:
https://doaj.org/article/06a80babc7d747e8a08bb4d32b7074de
Autor:
Celso E. Gomez-Sanchez, Desmaré van Rooyen, William E. Rainey, Kazutaka Nanba, Amy R. Blinder, Radhakrishna Baliga
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Aldosterone-producing adenoma is a rare cause of hypertension in children. Only a limited number of cases of aldosterone-producing adenomas with somatic KCNJ5 gene mutations have been described in children. Blacks are particularly more susceptible to
Externí odkaz:
https://doaj.org/article/ab449a8b5c8f4c5d881794cc23a575eb
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Aldosterone production is physiologically under the control of circulating potassium and angiotensin II as well as adrenocorticotropic hormone and other secretagogues such as serotonin. The adrenal’s capacity to produce aldosterone relies heavily o
Externí odkaz:
https://doaj.org/article/e31cbefc72d947ac9dd270764f7e7571
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
BackgroundSomatic gene mutations that facilitate inappropriate intracellular calcium entrance have been identified in most aldosterone-producing adenomas (APAs). Studies suggest that angiotensin II and adrenocorticotropic hormone (ACTH) augment aldos
Externí odkaz:
https://doaj.org/article/ac4d57a521834026b6421b68ad4db9eb
Autor:
Takuya Kitamura, Amy R Blinder, Kazutaka Nanba, Mika Tsuiki, Mutsuki Mishina, Hiroshi Okuno, Koki Moriyoshi, Yuto Yamazaki, Hironobu Sasano, Keisuke Yoneyama, Aaron M Udager, William E Rainey, Akihiro Yasoda, Noriko Satoh-Asahara, Tetsuya Tagami
Publikováno v:
European Journal of Endocrinology. 187:K39-K45
Although excess production of androgens and glucocorticoids has often been observed in adrenocortical carcinomas, adrenocortical adenoma with such hormonal activity is rare. Herein, we report a 41-year-old woman who presented with hyperandrogenemia a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6715138e50648aa93babd535f9db74d1
https://doi.org/10.1530/eje-22-0508
https://doi.org/10.1530/eje-22-0508
Autor:
Kimberly Wellman, Rui Fu, Amber Baldwin, Juilee Rege, Elisabeth Murphy, William E. Rainey, Neelanjan Mukherjee
Publikováno v:
Cells, Vol 10, Iss 9, p 2376 (2021)
Adrenal steroid hormone production is a dynamic process stimulated by adrenocorticotropic hormone (ACTH) and angiotensin II (AngII). These ligands initialize a rapid and robust gene expression response required for steroidogenesis. Here, we compare t
Externí odkaz:
https://doaj.org/article/e44a6c1a17ac4a5e9a84ae9b94512eeb
Autor:
Hiroki Shimada, Naotaka Kogure, Erika Noro, Masataka Kudo, Kaori Sugawara, Ikuko Sato, Kyoko Shimizu, Makoto Kobayashi, Dai Suzuki, Rehana Parvin, Takako Saito‐Ito, Akira Uruno, Akiko Saito‐Hakoda, William E. Rainey, Sadayoshi Ito, Atsushi Yokoyama, Akira Sugawara
Publikováno v:
FEBS Open Bio, Vol 7, Iss 9, Pp 1410-1421 (2017)
Aldosterone synthase is the key rate‐limiting enzyme in adrenal aldosterone production, and induction of its gene (CYP11B2) results in the progression of hypertension. As hypertension is a frequent complication among patients with diabetes, we set
Externí odkaz:
https://doaj.org/article/2ae9d397d3764417a027e9cbb10c10b1
Autor:
Nathan E. Rainey, Ana Saric, Alexandre Leberre, Etienne Dewailly, Christian Slomianny, Guillaume Vial, Harold I. Zeliger, Patrice X. Petit
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-20 (2017)
Abstract Humans are exposed to multiple exogenous environmental pollutants. Many of these compounds are parts of mixtures that can exacerbate harmful effects of the individual mixture components. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is primari
Externí odkaz:
https://doaj.org/article/12c798577ea7439c9deaed3a553f1af3
Autor:
Kazutaka Nanba, William E. Rainey
Publikováno v:
Curr Opin Endocrinol Diabetes Obes
PURPOSE OF REVIEW: Renin-independent aldosterone production from one or both affected adrenal(s), a condition known as primary aldosteronism (PA), is a common cause of secondary hypertension. In this review, we aimed to summarize recent findings rega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be83624cf162ff28db0683e5439477a
https://pubmed.ncbi.nlm.nih.gov/35621175
https://pubmed.ncbi.nlm.nih.gov/35621175