Zobrazeno 1 - 10
of 799
pro vyhledávání: '"E. Radford"'
Autor:
Bob Schiffrin, Joel A. Crossley, Martin Walko, Jonathan M. Machin, G. Nasir Khan, Iain W. Manfield, Andrew J. Wilson, David J. Brockwell, Tomas Fessl, Antonio N. Calabrese, Sheena E. Radford, Anastasia Zhuravleva
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The ATP-independent chaperone SurA protects unfolded outer membrane proteins (OMPs) from aggregation in the periplasm of Gram-negative bacteria, and delivers them to the β-barrel assembly machinery (BAM) for folding into the outer membrane
Externí odkaz:
https://doaj.org/article/b8ce23fd6b774989b970d0af57f9265e
Autor:
Katherine L. Fenn, Jim E. Horne, Joel A. Crossley, Nils Böhringer, Romany J. Horne, Till F. Schäberle, Antonio N. Calabrese, Sheena E. Radford, Neil A. Ranson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The outer membrane is a formidable barrier that protects Gram-negative bacteria against environmental threats. Its integrity requires the correct folding and insertion of outer membrane proteins (OMPs) by the membrane-embedded β-barrel asse
Externí odkaz:
https://doaj.org/article/e2d6b62a22094d6bb6804c36a81d4e8a
Autor:
Chalmers C. Chau, Christopher M. Maffeo, Aleksei Aksimentiev, Sheena E. Radford, Eric W. Hewitt, Paolo Actis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Controlled manipulation of cultured cells by delivery of exogenous macromolecules is a cornerstone of experimental biology. Here we describe a platform that uses nanopipettes to deliver defined numbers of macromolecules into cultured cell li
Externí odkaz:
https://doaj.org/article/3608c7ce0c4946648711d04cca233e42
Autor:
Nikolaos Louros, Martin Wilkinson, Grigoria Tsaka, Meine Ramakers, Chiara Morelli, Teresa Garcia, Rodrigo Gallardo, Sam D’Haeyer, Vera Goossens, Dominique Audenaert, Dietmar Rudolf Thal, Ian R. Mackenzie, Rosa Rademakers, Neil A. Ranson, Sheena E. Radford, Frederic Rousseau, Joost Schymkowitz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Tauopathies encompass a group of neurodegenerative disorders characterised by diverse tau amyloid fibril structures. The persistence of polymorphism across tauopathies suggests that distinct pathological conditions dictate the adopted polymo
Externí odkaz:
https://doaj.org/article/f3710df2103c4621bd7f36ca9c11b864
Autor:
Isobel K. Dunstan, Ross McLeod, Daniel E. Radford-Smith, Wenzheng Xiong, Trinity Pate, Fay Probert, Daniel C. Anthony
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
IntroductionPost-infection syndromes are characterised by fatigue, muscle pain, anhedonia, and cognitive impairment; mechanistic studies exploring these syndromes have focussed on pathways downstream of Toll-like receptor (TLR) 4 activation. Here, we
Externí odkaz:
https://doaj.org/article/9244bad03f17430d921628b23178d2c0
Autor:
Conny Leistner, Martin Wilkinson, Ailidh Burgess, Megan Lovatt, Stanley Goodbody, Yong Xu, Susan Deuchars, Sheena E. Radford, Neil A. Ranson, René A. W. Frank
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Amyloid plaques composed of Aβ fibrils are a hallmark of Alzheimer’s disease (AD). However, the molecular architecture of amyloid plaques in the context of fresh mammalian brain tissue is unknown. Here, using cryogenic correlated light an
Externí odkaz:
https://doaj.org/article/1dd0f73ed8e440b4a6e25d4257c0c4dc
Publikováno v:
Lipids in Health and Disease, Vol 22, Iss 1, Pp 1-17 (2023)
Abstract Endotoxemia and sepsis induce neuroinflammation and increase the risk of neurodegenerative disorders although the mechanism by which peripheral infection leads to brain inflammation is not well understood. While circulating serum lipoprotein
Externí odkaz:
https://doaj.org/article/a0ae16dbb7b5460b94d403c920a6f699
Autor:
Martin Wilkinson, Rodrigo U. Gallardo, Roberto Maya Martinez, Nicolas Guthertz, Masatomo So, Liam D. Aubrey, Sheena E. Radford, Neil A. Ranson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
The authors use cryo-EM to determine amyloid fibrils structures of disease relevant variants of β2-microglobulin in vitro. Each variant is polymorphic, but all polymorphs from all samples are built from a a lego-like assembly of common building bloc
Externí odkaz:
https://doaj.org/article/e2de69dabe954fc29c63847d4f346f10
Autor:
Daniel E. Radford-Smith, Daniel C. Anthony, Fee Benz, James T. Grist, Monty Lyman, Jack J. Miller, Fay Probert
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104643- (2023)
Summary: Background: Socioeconomic pressures, sex, and physical health status strongly influence the development of major depressive disorder (MDD) and mask other contributing factors in small cohorts. Resilient individuals overcome adversity without
Externí odkaz:
https://doaj.org/article/1fac2c44da6f4607b1a375839a2c23ff
Autor:
Sabine M. Ulamec, Roberto Maya-Martinez, Emily J. Byrd, Katherine M. Dewison, Yong Xu, Leon F. Willis, Frank Sobott, George R. Heath, Patricija van Oosten Hawle, Vladimir L. Buchman, Sheena E. Radford, David J. Brockwell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The authors of this work characterize the effect of amino acid substitution on α-synuclein (α-Syn) aggregation. Residues 38 and 42 (in addition to 39) within the P1 region of α-Syn affect amyloid formation. The effect of substitution at position 3
Externí odkaz:
https://doaj.org/article/795dea3b15b941688aa5f281361c1332