Zobrazeno 1 - 10
of 227
pro vyhledávání: '"E. R. Pfefferkorn"'
Autor:
E. R. Pfefferkorn, Buddy Ullman, John A. Darling, David S. Roos, Leah M. Fohl, Robert G. K. Donald, William J. Sullivan, Kshitiz Chaudhary
Publikováno v:
Journal of Biological Chemistry. 279:31221-31227
We have exploited a variety of molecular genetic, biochemical, and genomic techniques to investigate the roles of purine salvage enzymes in the protozoan parasite Toxoplasma gondii. The ability to generate defined genetic knockouts and target transge
Publikováno v:
Experimental Parasitology. 99:235-243
In contrast to the cytocidal effect of 6-thiopurines on mammalian cells, the action of 6-thioxanthine on Toxoplasma gondii was only parasitostatic. 6-Thioxanthine was a substrate of the parasite's hypoxanthine-guanine phosphoribosyltransferase. That
Autor:
E. R. Pfefferkorn, Susan E. Borotz
Publikováno v:
Experimental Parasitology. 79:374-382
6-Thioxanthine caused 50% inhibition of the growth of Toxoplasma gondii in human fibroblasts at a concentration of 5 micrograms/ml. A mutant induced by treatment with ethylnitrosourea (ThxR-1) was 20-fold more resistant than the wildtype. Wild-type p
Autor:
Susan E. Borotz, E. R. Pfefferkorn
Publikováno v:
Antimicrobial Agents and Chemotherapy. 38:31-37
Azithromycin and spiramycin markedly inhibited the growth of Toxoplasma gondii in cultured human fibroblasts. However, 3 days of treatment were required to reveal their full antitoxoplasma activity. This delayed onset of inhibition was similar to tha
Autor:
A. P. Ricketts, E R Pfefferkorn
Publikováno v:
Antimicrobial Agents and Chemotherapy. 37:2358-2363
Anticoccidial drugs were evaluated for activity and for the development of resistance in a model of Toxoplasma gondii growing in human fibroblast cultures. Of 13 anticoccidial drugs tested, 9 had selective antitoxoplasma activity (50% inhibitory conc
Publikováno v:
Parasitology Today. 9:392-395
The protozoan parasite Toxoplasma gondii has recently emerged as an important opportunistic pathogen in humans. Toxoplasma also shares a number of biological features with Plasmodium and Eimeria, which are important pathogens of humans and animals. B
Publikováno v:
The Journal of Immunology. 146:3145-3151
The three types of IgG FcR (Fc gamma RI, Fc gamma RII, Fc gamma RIII) on human leukocytes play an important role in elimination of antibody-coated infectious agents. To further understand the role of the different Fc gamma R in mediating this killing
Autor:
Björn Folkow, E. R. Pfefferkorn
Publikováno v:
Ciba Foundation Symposium 100-Development of the Vascular System
Blood vessels readily adapt their design in response to sustained functional changes. If pressure (P) increases, the resulting thickening of the walls (w) of the resistance vessels, associated with a reduction in average inner radius (ri), keeps wall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4796b111a58c7ca919e43d697cc172b5
https://doi.org/10.1002/9780470720813.ch5
https://doi.org/10.1002/9780470720813.ch5
Publikováno v:
Ciba Foundation Symposium 99-Cytopathology of Parasitic Disease ISBN: 9780470720806
Ciba Foundation Symposium 99-Cytopathology of Parasitic Disease
Ciba Foundation Symposium 99-Cytopathology of Parasitic Disease
Toxoplasma gondii, an obligate intracellular parasite, is readily grown in nearly all cultured cells. The host-parasite relationship in these cultures can often be explored by using mutant host cells or mutant parasites. Host cells incapable of incor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9ed52d8279a018a077ce0f87a05eebd
https://doi.org/10.1002/9780470720806.ch5
https://doi.org/10.1002/9780470720806.ch5