Výsledky vyhledávání - "E. R. Barrack"

Androgen receptor variants with short glutamine or glycine repeats may identify unique subpopulations of men with prostate cancer

Autor: J M, Hakimi, M P, Schoenberg, R H, Rondinelli, S, Piantadosi, E R, Barrack

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 3(9)

The androgen receptor (AR) contains glutamine (CAG) and glycine (GGC) repeats that are each polymorphic in length. We screened clinically localized prostate cancers for somatic mutations in the length of the CAG and GGC repeats in the AR gene and cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8bb090013d53550449e03590ad0dcb93
https://pubmed.ncbi.nlm.nih.gov/9815849

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TGF beta in prostate cancer: a growth inhibitor that can enhance tumorigenicity

Autor: E R, Barrack

Publikováno v: The Prostate. 31(1)

A common feature of cancer cells is the autocrine production of growth promoters and the loss of function of tumor suppressors. In our search for such features of prostate cancer, we discovered that transforming growth factor beta 1 (TGF beta 1) leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::80744516bb34f625b63d38963ba21e08
https://pubmed.ncbi.nlm.nih.gov/9108888

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Androgen receptor mutations in prostate cancer

Autor: E R, Barrack

Publikováno v: The Mount Sinai journal of medicine, New York. 63(5-6)

AR gene mutations occur in both early-stage prostate cancers (28, 51, our unpublished data) and late-stage disease (36, 37, 55-57). One common feature is that both types of mutations retain ligand-dependent transcriptional activity. We speculate that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0a78cd7cf0115da08c33599152d4fbc
https://pubmed.ncbi.nlm.nih.gov/8898547

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Modulation of transforming growth factor beta 1 effects on prostate cancer cell proliferation by growth factors and extracellular matrix

Autor: D M, Morton, E R, Barrack

Publikováno v: Cancer research. 55(12)

Poorly differentiated MATLyLu rat prostate cancer cells are resistant to the growth inhibitory effect of transforming growth factor (TGF) beta 1 in vivo, but are inhibited by TGF-beta 1 in vitro. However, TGF-beta 1 inhibited proliferation only when

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd1220a37124a90fae747f488bfc591d
https://pubmed.ncbi.nlm.nih.gov/7780974

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Image analysis of androgen receptor immunostaining in metastatic prostate cancer. Heterogeneity as a predictor of response to hormonal therapy

Autor: M V, Sadi, E R, Barrack

Publikováno v: Cancer. 71(8)

Reliable predictors of the response of prostate cancer to androgen ablation therapy are lacking. The goals of this study were to determine whether nuclear androgen receptor (AR) concentrations in metastatic prostate cancer varied within and between s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::29d6f1bad1ff34fb93b615bc61f3b1f8
https://pubmed.ncbi.nlm.nih.gov/7680949

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Immunohistochemical study of androgen receptors in metastatic prostate cancer. Comparison of receptor content and response to hormonal therapy

Autor: M V, Sadi, P C, Walsh, E R, Barrack

Publikováno v: Cancer. 67(12)

A longstanding goal has been to determine whether androgen receptor (AR) levels could be used to predict the clinical response of metastatic prostate cancer to androgen withdrawal therapy. A major limitation of previous studies was the use of homogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c42326829009728e5dfe6c8af5d2ef6
https://pubmed.ncbi.nlm.nih.gov/1710537

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Determination of growth fraction in advanced prostate cancer by Ki-67 immunostaining and its relationship to the time to tumor progression after hormonal therapy

Autor: M V, Sadi, E R, Barrack

Publikováno v: Cancer. 67(12)

Reliable predictors of response for prostate cancer patients undergoing hormonal therapy are lacking. This study investigates the possibility that tumor proliferation rates might predict tumor behavior for these patients. The growth fraction of metas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5ce3d27ab593c4a69a09f95c9cd559c4
https://pubmed.ncbi.nlm.nih.gov/1710538

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Androgen receptors and growth fraction in metastatic prostate cancer as predictors of time to tumour progression after hormonal therapy

Autor: M V, Sadi, E R, Barrack

Publikováno v: Cancer surveys. 11

Reliable predictors of response for prostate cancer patients undergoing hormone therapy are lacking. Since 80-90% of such patients do respond but the time between therapy and relapse (progression) is variable, our goal has been to predict the time to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::52955071dc948cc656af3f3fe251366e
https://pubmed.ncbi.nlm.nih.gov/1841752

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The specific binding of estrogens and androgens to the nuclear matrix of sex hormone responsive tissues

Autor: D S Coffey, E R Barrack

Publikováno v: Journal of Biological Chemistry. 255:7265-7275

Specific sex steroid hormone binding sites have been identified in a discrete nuclear subfraction that is chromatin-depleted and salt-insoluble. This structure, referred to as the nuclear matrix, contains a residual pore complex-lamina, remnants of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34813cda7b997b903d4b69db540db33f
https://doi.org/10.1016/s0021-9258(20)79697-3

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