Designing target trials using electronic health records: A case study of second-line disease-modifying anti-rheumatic drugs and cardiovascular disease outcomes in patients with rheumatoid arthritis.

Autor: Adovich S Rivera, Jacob B Pierce, Arjun Sinha, Anna E Pawlowski, Donald M Lloyd-Jones, Yvonne C Lee, Matthew J Feinstein, Lucia C Petito

Publikováno v: PLoS ONE, Vol 19, Iss 6, p e0305467 (2024)

BackgroundEmulation of the "target trial" (TT), a hypothetical pragmatic randomized controlled trial (RCT), using observational data can be used to mitigate issues commonly encountered in comparative effectiveness research (CER) when randomized trial

Externí odkaz: https://doaj.org/article/9a3d4db4e86c4062a9f86353a45a55a2

Timing of Intubation in Coronavirus Disease 2019: A Study of Ventilator Mechanics, Imaging, Findings, and Outcomes

Autor: Avni A. Bavishi, MD, MS, Ruben J. Mylvaganam, MD, Rishi Agarwal, MD, Ryan J. Avery, MD, Michael J. Cuttica, MD, For the NU COVID Investigators, A. Christine Argento, Ajay A. Wagh, Alexander V. Misharin, Alexandra C. McQuattie-Pimentel, Alexis Rose Wolfe, Alvaro Donayre, Ankit Bharat, Anna E. Pawlowski, Anne R. Levenson, Anthony M. Joudi, Benjamin D. Singer, Betty Tran, Catherine A. Gao, Chao Qi, Chiagozie O. Pickens, Chitaru Kurihara, Clara J. Schroedl, Daniel Meza, Daniel Schneider, David A. Kidd, David D. Odell, David W. Kamp, Elizabeth S. Malsin, Emily M. Leibenguth, Eric P. Cantey, Gabrielle Y. Liu, G. R. Scott Budinger, Helen K. Donnelly, Isaac A. Goldberg, Jacob I. Sznajder, Jacqueline M. Kruser, James M. Walter, Jane E. Dematte, Jason M. Arnold, John Coleman, Joseph I. Bailey, Joseph S. Deters, Justin A. Fiala, Katharine Secunda, Kaitlyn Vitale, Khalilah L. Gates, Kristy Todd, Lindsey D. Gradone, Lindsey N. Textor, Lisa F. Wolfe, Lorenzo L. Pesce, Luisa Morales-Nebreda, Madeline L. Rosenbaum, Manu Jain, Marc A. Sala, Mary Carns, Marysa V. Leya, Mengjia Kang, Michael J. Alexander, Michael J. Cuttica, Michelle Hinsch Prickett, Natalie Jensema, Nicole Borkowski, Nikolay S. Markov, Orlyn R. Rivas, Paul A. Reyfman, Peter H. S. Sporn, Prasanth Nannapaneni, Rachel B. Kadar, Rachel M. Kaplan, Rade Tomic, Radhika Patel, Rafael Garza-Castillon, Ravi Kalhan, Richard G. Wunderink, Rogan A. Grant, Romy Lawrence, Ruben J. Mylvaganam, Samuel S. Kim, Sanket Thakkar, Sean B. Smith, SeungHye Han, Sharon R. Rosenberg, Susan R. Russell, Sydney M. Hyder, Taylor A. Poor, Theresa A. Lombardo, Zasu M. Klug

Publikováno v: Critical Care Explorations, Vol 3, Iss 5, p e0415 (2021)

Objectives:. Determine the variation in outcomes and respiratory mechanics between the subjects who are intubated earlier versus later in their coronavirus disease 2019 course. Design:. Retrospective cohort study. Setting:. Northwestern Memorial Hosp

Externí odkaz: https://doaj.org/article/a5ecd5f3973e465d9c9346646dbe1a1d

Machine learning links unresolving secondary pneumonia to mortality in patients with severe pneumonia, including COVID-19

Autor: Catherine A. Gao, Nikolay S. Markov, Thomas Stoeger, Anna E. Pawlowski, Mengjia Kang, Prasanth Nannapaneni, Rogan A. Grant, Chiagozie Pickens, James M. Walter, Jacqueline M. Kruser, Luke V. Rasmussen, Daniel Schneider, Justin Starren, Helen K. Donnelly, Alvaro Donayre, Yuan Luo, G.R. Scott Budinger, Richard G. Wunderink, Alexander V. Misharin, Benjamin D. Singer

Publikováno v: Journal of Clinical Investigation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3b4ea4624551eff7c0b284ed063e250
https://doi.org/10.1172/jci170682

Machine Learning To Stratify Methicillin-Resistant Staphylococcus aureus Risk among Hospitalized Patients with Community-Acquired Pneumonia

Autor: Nathaniel J. Rhodes, Roxane Rohani, Paul R. Yarnold, Anna E. Pawlowski, Michael Malczynski, Chao Qi, Sarah H. Sutton, Teresa R. Zembower, Richard G. Wunderink

Publikováno v: Antimicrob Agents Chemother

Methicillin-resistant Staphylococcus aureus (MRSA) is an uncommon but serious cause of community-acquired pneumonia (CAP). A lack of validated MRSA CAP risk factors can result in overuse of empirical broad-spectrum antibiotics. We sought to develop r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44c47700722ae63cd79d25a36f9e556
https://europepmc.org/articles/PMC9872682/

Atrial arrhythmia prevalence and characteristics for human immunodeficiency virus-infected persons and matched uninfected controls.

Autor: Jes M Sanders, Alexandra B Steverson, Anna E Pawlowski, Daniel Schneider, Chad J Achenbach, Donald M Lloyd-Jones, Matthew J Feinstein

Publikováno v: PLoS ONE, Vol 13, Iss 3, p e0194754 (2018)

BACKGROUND:Human Immunodeficiency Virus-Infected (HIV+) persons have elevated risks for various manifestations of cardiovascular disease (CVD). No studies to our knowledge have compared atrial fibrillation (AF) and atrial flutter (AFL) prevalence and

Externí odkaz: https://doaj.org/article/82a9ffece8964cc0be30f0c5d5388193