Zobrazeno 1 - 10
of 57
pro vyhledávání: '"E. P. Noble"'
Autor:
Rhianna J. Rowland, Svitlana Korolchuk, Marco Salamina, Natalie J. Tatum, James R. Ault, Sam Hart, Johan P. Turkenburg, James N. Blaza, Martin E. M. Noble, Jane A. Endicott
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The cell division cycle 25 phosphatases CDC25A, B and C regulate cell cycle transitions by dephosphorylating residues in the conserved glycine-rich loop of CDKs to activate their activity. Here, we present the cryo-EM structure of CDK2-cycli
Externí odkaz:
https://doaj.org/article/7f9036edb0fb4c63978dfd51fe5e5873
Autor:
Rhianna J. Rowland, Richard Heath, Daniel Maskell, Rebecca F. Thompson, Neil A. Ranson, James N. Blaza, Jane A. Endicott, Martin E. M. Noble, Marco Salamina
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract p27KIP1 (cyclin-dependent kinase inhibitor 1B, p27) is a member of the CIP/KIP family of CDK (cyclin dependent kinase) regulators that inhibit cell cycle CDKs. p27 phosphorylation by CDK1/2, signals its recruitment to the SCFSKP2 (S-phase ki
Externí odkaz:
https://doaj.org/article/255a782ee4174ccbb388f8fffc48d107
Autor:
Alice Douangamath, Daren Fearon, Paul Gehrtz, Tobias Krojer, Petra Lukacik, C. David Owen, Efrat Resnick, Claire Strain-Damerell, Anthony Aimon, Péter Ábrányi-Balogh, José Brandão-Neto, Anna Carbery, Gemma Davison, Alexandre Dias, Thomas D. Downes, Louise Dunnett, Michael Fairhead, James D. Firth, S. Paul Jones, Aaron Keeley, György M. Keserü, Hanna F. Klein, Mathew P. Martin, Martin E. M. Noble, Peter O’Brien, Ailsa Powell, Rambabu N. Reddi, Rachael Skyner, Matthew Snee, Michael J. Waring, Conor Wild, Nir London, Frank von Delft, Martin A. Walsh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The SARS-CoV-2 main protease is an important target for the development of COVID-19 therapeutics. Here, the authors combine X-ray crystallography and mass spectrometry and performed a large scale fragment screening campaign, which yielded 96 liganded
Externí odkaz:
https://doaj.org/article/d499338758524d99942f9963faf75661
Autor:
Pamela A. Lochhead, Julie A. Tucker, Natalie J. Tatum, Jinhua Wang, David Oxley, Andrew M. Kidger, Victoria P. Johnson, Megan A. Cassidy, Nathanael S. Gray, Martin E. M. Noble, Simon J. Cook
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Selective ERK5 inhibitors target ERK5 kinase activity, but they do not phenocopy the effects of ERK5 genetic depletion. Here, the authors demonstrate that the direct interaction of these inhibitors to ERK5 kinase domain induces conformational changes
Externí odkaz:
https://doaj.org/article/74f91df61c624308a4815d6adcffb1f9
Autor:
Alfredo E. Tadeo Noble, Héctor M. De Los Santos Posadas, Gregorio Ángeles Pérez, Jorge A. Torres Pérez
Publikováno v:
Revista Mexicana de Ciencias Forestales, Vol 5, Iss 25, Pp 64-83 (2018)
Se proponen los estimadores muestrales para el análisis del inventario forestal del ejido Noh Bec y su remedición. Se analizó la información proveniente de 302 conglomerados distribuidos en cuatro estratos de selva mediana subperennifolia est
Externí odkaz:
https://doaj.org/article/58139d20905242e0bcdf9b813ad91682
Autor:
E. P. Noble
Publikováno v:
European Psychiatry. 15:79-89
SummarySince 1990, association studies have amassed strong evidence implicating the D2dopamine receptor (DRD2) gene in alcoholism. Specifically, theTaql A minor (A1) allele of the DRD2 gene has been associated with alcoholism. The DRD2 gene has also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1ab6f17d7450044fb983d7ceb869a5
https://doi.org/10.1016/s0924-9338(00)00208-x
https://doi.org/10.1016/s0924-9338(00)00208-x
Autor:
B, Lawford, R, Young, E P, Noble, D, Crawford, J, Rowell, S, Shadforth, T, Ritchie, X, Zhang, G E, Cooksley
Publikováno v:
Addiction biology. 4(1)
Hepatitis C is highly prevalent among intravenous drug abusers, but to date research has not widely explicated behavioural risk factors regarding acquisition of infection. The A₁allele of the D₂ dopamine receptor (DRD2) gene is a hypothesized ris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::518bb73fef264049d35dea2a3285f686
https://pubmed.ncbi.nlm.nih.gov/20575771
https://pubmed.ncbi.nlm.nih.gov/20575771
Publikováno v:
Journal of Biological Chemistry. 267:10607-10612
Chick brain precursor neurons were observed to introduce sialic acid biosynthetically into only three specific gangliosides: monosialosyl lactosyl ceramide (GM3), disialosyl lactosyl ceramide (GD3), and disialosyl gangliotrihexosyl ceramide (GD2), wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9f29235ea6ab73d37686ff0ddd8dda0
https://doi.org/10.1016/s0021-9258(19)50060-6
https://doi.org/10.1016/s0021-9258(19)50060-6
Autor:
C. Phillip Morris, Bruce R. Lawford, Christopher D. Swagell, Ian P. Hughes, Karen Heslop, Joanne Voisey, E. P. Noble, Ross McD. Young, Burnett Kann, Angela van Daal
Publikováno v:
Depression and anxiety. 26(1)
Background: Variations in genes related to the dopaminergic pathway have been implicated in neuropsychiatric disorders such as schizophrenia, substance misuse, Alzheimer's disease and Post Traumatic Stress Disorder (PTSD). A single nucleotide polymor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cc0daa88d152ec747a2c5764848174
https://pubmed.ncbi.nlm.nih.gov/18833581
https://pubmed.ncbi.nlm.nih.gov/18833581
Publikováno v:
Addictive behaviors. 29(7)
Substance misuse is influenced by multiple genetic and environmental factors. Recent research has identified a number of potential genetic markers of risk and those associated with drug reward substrates show particular promise. The current study ree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163ec9fd53fb580122cb7235fdc87202
https://pubmed.ncbi.nlm.nih.gov/15345265
https://pubmed.ncbi.nlm.nih.gov/15345265