Zobrazeno 1 - 10
of 97
pro vyhledávání: '"E. Olander"'
Autor:
Nabeel Bardeesy, Robert T. Manguso, Hongwu Zheng, Rahul M. Kohli, Vikram Deshpande, Brandon Nicolay, Lipika Goyal, Cristina R. Ferrone, Mathias Heikenwälder, Tong Wang, Russell W. Jenkins, Rodrigo Saad-Berreta, Yi Sun, Sebastien Ronseaux, Christine Hudson, Mirian Fernández-Vaquero, María García-Beccaria, William Shen, Meiqi Luo, Qibiao Wu, Yuanli Zhen, Vajira Weeresekara, Krishna Seshu Tummala, Amaya Pankaj, Ramzi Adil, Kira E. Olander, Emily Kessler, Ting-Yu Wei, Vindhya Vijay, Joshua Merritt, Juan Dubrot, Lei Shi, Meng-Ju Wu
Supplementary table from Mutant IDH Inhibits IFNγ–TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4591e78e7671b476dda13e33c1b01770
https://doi.org/10.1158/2159-8290.22541389
https://doi.org/10.1158/2159-8290.22541389
Autor:
Nabeel Bardeesy, Robert T. Manguso, Hongwu Zheng, Rahul M. Kohli, Vikram Deshpande, Brandon Nicolay, Lipika Goyal, Cristina R. Ferrone, Mathias Heikenwälder, Tong Wang, Russell W. Jenkins, Rodrigo Saad-Berreta, Yi Sun, Sebastien Ronseaux, Christine Hudson, Mirian Fernández-Vaquero, María García-Beccaria, William Shen, Meiqi Luo, Qibiao Wu, Yuanli Zhen, Vajira Weeresekara, Krishna Seshu Tummala, Amaya Pankaj, Ramzi Adil, Kira E. Olander, Emily Kessler, Ting-Yu Wei, Vindhya Vijay, Joshua Merritt, Juan Dubrot, Lei Shi, Meng-Ju Wu
Supplementary Figure from Mutant IDH Inhibits IFNγ–TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f285ec531b322829e126b3586d7fc7
https://doi.org/10.1158/2159-8290.22541395.v1
https://doi.org/10.1158/2159-8290.22541395.v1
Autor:
Nabeel Bardeesy, Robert T. Manguso, Hongwu Zheng, Rahul M. Kohli, Vikram Deshpande, Brandon Nicolay, Lipika Goyal, Cristina R. Ferrone, Mathias Heikenwälder, Tong Wang, Russell W. Jenkins, Rodrigo Saad-Berreta, Yi Sun, Sebastien Ronseaux, Christine Hudson, Mirian Fernández-Vaquero, María García-Beccaria, William Shen, Meiqi Luo, Qibiao Wu, Yuanli Zhen, Vajira Weeresekara, Krishna Seshu Tummala, Amaya Pankaj, Ramzi Adil, Kira E. Olander, Emily Kessler, Ting-Yu Wei, Vindhya Vijay, Joshua Merritt, Juan Dubrot, Lei Shi, Meng-Ju Wu
Isocitrate dehydrogenase 1 mutations (mIDH1) are common in cholangiocarcinoma. (R)-2-hydroxyglutarate generated by the mIDH1 enzyme inhibits multiple α-ketoglutarate–dependent enzymes, altering epigenetics and metabolism. Here, by developing mIDH1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28dbb03d0373c9d903a08ccbd12df350
https://doi.org/10.1158/2159-8290.c.6549628.v1
https://doi.org/10.1158/2159-8290.c.6549628.v1
Autor:
Emily Kessler, Rodrigo Saad-Berreta, Hongwu Zheng, Vikram Deshpande, Krishna S. Tummala, Brandon Nicolay, William Shen, Ramzi Adil, Meng-Ju Wu, Juan Dubrot, Lipika Goyal, Vajira Weeresekara, Amaya Pankaj, Mathias Heikenwalder, Tong Wang, Mirian Fernandez-Vaquero, María García-Beccaria, Ting-Yu Wei, Kira E Olander, Sebastien Ronseaux, Vindhya Vijay, Qibiao Wu, Yuanli Zhen, Christine Hudson, Nabeel Bardeesy, Lei Shi, Rahul M. Kohli, Meiqi Luo, Yi Sun, Russell W. Jenkins, Robert T. Manguso, Cristina R. Ferrone, Joshua Merritt
Publikováno v:
Cancer Discovery. 12:812-835
Isocitrate dehydrogenase 1 mutations (mIDH1) are common in cholangiocarcinoma. (R)-2-hydroxyglutarate generated by the mIDH1 enzyme inhibits multiple α-ketoglutarate–dependent enzymes, altering epigenetics and metabolism. Here, by developing mIDH1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f862d0e585b8159d6489f25b69e68d80
https://doi.org/10.1158/2159-8290.cd-21-1077
https://doi.org/10.1158/2159-8290.cd-21-1077
Autor:
Juan Dubrot, Peter P. Du, Sarah Kate Lane-Reticker, Emily A. Kessler, Audrey J. Muscato, Arnav Mehta, Samuel S. Freeman, Peter M. Allen, Kira E. Olander, Kyle M. Ockerman, Clara H. Wolfe, Fabius Wiesmann, Nelson H. Knudsen, Hsiao-Wei Tsao, Arvin Iracheta-Vellve, Emily M. Schneider, Andrea N. Rivera-Rosario, Ian C. Kohnle, Hans W. Pope, Austin Ayer, Gargi Mishra, Margaret D. Zimmer, Sarah Y. Kim, Animesh Mahapatra, Hakimeh Ebrahimi-Nik, Dennie T. Frederick, Genevieve M. Boland, W. Nicholas Haining, David E. Root, John G. Doench, Nir Hacohen, Kathleen B. Yates, Robert T. Manguso
Publikováno v:
Nature immunology. 23(10)
The immune system can eliminate tumors, but checkpoints enable immune escape. Here, we identify immune evasion mechanisms using genome-scale in vivo CRISPR screens across cancer models treated with immune checkpoint blockade (ICB). We identify immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2baea80423306b35717a112e6865b459
https://pubmed.ncbi.nlm.nih.gov/36151395
https://pubmed.ncbi.nlm.nih.gov/36151395
Autor:
Hakimeh Ebrahimi-Nik, Arvin Iracheta-Vellve, Kira E. Olander, Thomas R.G. Davis, Sarah Y. Kim, Mitchell D. Yeary, James C. Patti, Tyler M. Balon, Omar Ismail Avila, Cun Lan Chuong, Meng-Ju Wu, Christina K. Baumgartner, Keith M. Hamel, Kathleen A. McGuire, Rebecca Mathew, Carey Backus, Ian C. Kohnle, Zhaoming Xiong, Elliot P. Farney, Jennifer M. Frost, Geoff T. Halvorsen, Matthew Rees, Andrew Boghossian, Melissa Ronan, Jennifer A. Roth, Todd R. Golub, Gabriel K. Griffin, Nabeel El-Bardeesy, Clay C. Beauregard, Philip R. Kym, Kathleen B. Yates, Robert T. Manguso
Publikováno v:
Cancer Immunology Research. 10:A41-A41
Immune checkpoint blockade is effective for a subset of patients across many cancers, but most patients are refractory to current immunotherapies and new approaches are needed to overcome resistance. The protein tyrosine phosphatase PTPN2 is a centra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62f4e8814e7bd29051c6abf0b707bbe5
https://doi.org/10.1158/2326-6074.tumimm22-a41
https://doi.org/10.1158/2326-6074.tumimm22-a41
Publikováno v:
European Journal of Public Health. 31
Background During pregnancy, women's mental and physical health, health behaviours, and experiences of maternity care can have significant implications for obstetric, maternal and child outcomes. These factors can be impacted by adverse life-events,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0157d08835b8cc72d0831c55c7bf2ca5
https://doi.org/10.1093/eurpub/ckab164.686
https://doi.org/10.1093/eurpub/ckab164.686
Autor:
Arvin Iracheta-Vellve, Hakimeh Ebrahimi-Nik, Thomas R. Davis, Kira E. Olander, Sarah Y. Kim, Mitchell D. Yeary, James C. Patti, Ian C. Kohnle, Christina K. Baumgartner, Keith M. Hamel, Kathleen A. McGuire, Cun Lan Chuong, Zhaoming Xiong, Elliot P. Farney, Jennifer M. Frost, Matthew Rees, Andrew Boghossian, Melissa Ronan, Jennifer A. Roth, Todd R. Golub, Gabriel K. Griffin, Clay Beauregard, Philip R. Kym, Kathleen B. Yates, Robert T. Manguso
Publikováno v:
Cancer Research. 82:606-606
Immune checkpoint blockade is effective for a subset of patients across many cancers, but most patients are refractory to current immunotherapies and new approaches are needed to overcome resistance. The protein tyrosine phosphatase PTPN2 is a centra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41bf1f8f30988b71b649ed6c58e4e9df
https://doi.org/10.1158/1538-7445.am2022-606
https://doi.org/10.1158/1538-7445.am2022-606
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 315:H1544-H1552
Cardiomyopathy is a significant contributor to morbidity and mortality in Duchenne muscular dystrophy (DMD). Membrane instability, leading to intracellular Ca2+ mishandling and overload, causes myocyte death and subsequent fibrosis in DMD cardiomyopa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fe897886cd84a39f6b5baf33d00282
https://doi.org/10.1152/ajpheart.00341.2018
https://doi.org/10.1152/ajpheart.00341.2018
Autor:
Susan Klaeger, John G. Doench, Jingyi Wu, Aya G Halawi, Emily M Schneider, Brian C. Miller, Emily J. Robitschek, Bradley E. Bernstein, Malvina Papanastasiou, Nelson H. Knudsen, Tung H Nguyen, Deborah Dele-Oni, Mitchell D Yeary, Kira E Olander, Kathleen B. Yates, James C Patti, Thomas Davis, Suzanna Rachimi, Robert T. Manguso, Jacob D. Jaffe, Gabriel K. Griffin, Jeffrey J. Ishizuka, W. Nicholas Haining, Jeffrey Hsu, Arvin Iracheta-Vellve, Steven A. Carr, Peter P. Du, Sarah Y Kim, Margaret D. Zimmer
Publikováno v:
Nature
Epigenetic dysregulation is a defining feature of tumorigenesis that is implicated in immune escape1,2. Here, to identify factors that modulate the immune sensitivity of cancer cells, we performed in vivo CRISPR-Cas9 screens targeting 936 chromatin r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef05e15bb6d81b801aecc3c45512f1c
https://pubmed.ncbi.nlm.nih.gov/34906316
https://pubmed.ncbi.nlm.nih.gov/34906316