Výsledky vyhledávání - "E. O. Yablokov"

Screening of potential non-azole inhibitors of lanosterol14-alpha demethylase (CYP51) of Candida fungi

Autor: A S Ivanov, T. V. Shkel, Sergei A. Usanov, Oksana Gnedenko, L. A. Kaluzhskiy, Andrey Gilep, E O Yablokov, Yuri Mezentsev, P V Ershov

Publikováno v: Biomeditsinskaya Khimiya. 67:42-50

Currently, opportunistic fungi of the genus Candida are the main causative agents of mycoses, which are especially severe upon condition of acquired immunodeficiency. The main target for the development of new antimycotics is the cytochrome P450 51 (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c0a0380bed756057a01badbc2e4231
https://doi.org/10.18097/pbmc20216701042

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Application of the SPR Biosensor for the Analysis of Protein–Protein Interactions in Aqueous Environment and Bilayer Lipid Membrane As Exemplified by P450scc (CYP11A1)

Autor: A. M. Tumilovich, Andrey Gilep, Anton Kavaleuski, P V Ershov, Andrew Ivanov, E O Yablokov, L. A. Kaluzhskiy, Natallia Strushkevich, Oksana Gnedenko

Publikováno v: Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 15:89-96

Protein–protein interactions (PPIs) are crucial for the successful realization of many metabolic and signaling pathways. Of particular interest are PPIs of membrane proteins, which form stable and/or transient complexes for the signal transduction,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::114d3a4162559c2b353c6bf74edf2177
https://doi.org/10.1134/s1990747821010049

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SPR Analysis of Protein-Protein Interactions Involving Cytochromes P450 and Cytochrome b5 Integrated into Lipid Membrane

Autor: A S Ivanov, T. V. Shkel, E O Yablokov, G. V. Sergeev, K. S. Kurpedinov, P V Ershov, L. A. Kaluzhskiy, I. V. Haidukevich, Sergei A. Usanov, D. S. Sonina

Publikováno v: Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry. 14:168-173

Identification of new protein-protein interactions (PPI) and characterization of quantitative parameters of complex formation represent one of central tasks of modern protein interactomics. This study is a logical continuation of the cycle of our pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10174d0fdbee09db6c3481700ac2e8f7
https://doi.org/10.1134/s1990750820020067

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Прямой молекулярный фишинг цинкзависимых белковых партнеров бета-амилоида 1–16 с 'Тайваньской' (D7H) мутацией и с фосфорилированным остатком Ser8

Autor: P V Ershov, Nikolai V. Gnuchev, Alexander A. Makarov, Vladimir A. Mitkevich, E O Yablokov, Yu. V. Mezentsev, Andrew Ivanov, L A Kaluzgskiy, Sergey A. Kozin

Publikováno v: Молекулярная биология. 54:1029-1036

We previously showed that the metal-binding domain 1-16 of intact amyloid-beta (Aβ) is involved in interactions with a number of proteins from the cytosolic fraction of SK-N-SH human neuroblastoma cells in a zinc-dependent manner only. It is known t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::167dafba351cd21ae2cc535a96fcb11e
https://doi.org/10.31857/s0026898420060038

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Interaction of prostacyclin synthase with cytochromes P450

Autor: A S Ivanov, T. V. Shkel, S A Usanov, A. A. Gilep, P V Ershov, Natallia Strushkevich, Oksana Gnedenko, E O Yablokov, A V Svirid, I. V. Haidukevich

Publikováno v: Biomeditsinskaya Khimiya. 65:63-66

Biosensor experiments on investigation of interaction between prostacyclin synthase (PGIS) and different proteins of the cytochrome P450 monooxygenase systems were perfomed. Interaction of PGIS with microsomal (CYP21A2, CYP2E1) and mitochondrial (CYP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92c16602fda5159ddc7d918abacc260
https://doi.org/10.18097/pbmc20196501063

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Substrate-induced modulation of protein-protein interactions within human mitochondrial cytochrome P450-dependent system

Autor: Andrey Gilep, Anton Kavaleuski, P V Ershov, Natallia Strushkevich, А.S. Ivanov, Y. V. Mezentsev, L. A. Kaluzhskiy, T. A. Sushko, E O Yablokov

Publikováno v: The Journal of steroid biochemistry and molecular biology. 208

Steroidogenesis is strictly regulated at multiple levels, as produced steroid hormones are crucial to maintain physiological functions. Cytochrome P450 enzymes are key players in adrenal steroid hormone biosynthesis and function within short redox-ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b804f1c1ccb9c1d3d6f947041f0d55d4
https://pubmed.ncbi.nlm.nih.gov/33271253

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[Direct Molecular Fishing of Zinc-Dependent Protein Partners of Amyloid-beta 1-16 with the Taiwan (D7H) Mutation and Phosphorylated Ser8 Residue]

Autor: P V, Ershov, Yu V, Mezentsev, E O, Yablokov, L A, Kaluzgskiy, A S, Ivanov, N V, Gnuchev, V A, Mitkevich, A A, Makarov, S A, Kozin

Publikováno v: Molekuliarnaia biologiia. 54(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f1b494c5c64a5326ccbbca520a869562
https://pubmed.ncbi.nlm.nih.gov/33276366

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Direct Molecular Fishing of Protein Partners for Proteins Encoded by Genes of Human Chromosome 18 in HepG2 Cell Lysate

Autor: Konstantin N. Yarygin, Oksana Gnedenko, A. V. Florinskaya, I. V. Vakhrushev, P V Ershov, E O Yablokov, L. A. Kaluzhskiy, Alexei Medvedev, Yu. V. Mezentsev, A. S. Ivanov, Andrey Gilep, V. G. Zgoda, Sergei A. Usanov, O. S. Raeva

Publikováno v: Russian Journal of Bioorganic Chemistry. 44:759-768

The aim of this work was to identify the spectrum of possible protein-protein interactions (PPI) for six target proteins (CYB5A, RAB27B, SMAD4, CXXC1, RNMT, ТТR) encoded by genes of human chromosome 18, which have a certain medical significance. Fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b85339f20b8439cd1e276a2a0794338
https://doi.org/10.1134/s1068162019010059

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