Zobrazeno 1 - 10
of 18
pro vyhledávání: '"E. Nicholas Petersen"'
Autor:
E Nicholas Petersen, Mahmud Arif Pavel, Samuel S Hansen, Manasa Gudheti, Hao Wang, Zixuan Yuan, Keith R Murphy, William Ja, Heather A Ferris, Erik Jorgensen, Scott B Hansen
Publikováno v:
eLife, Vol 12 (2024)
Rapid conversion of force into a biological signal enables living cells to respond to mechanical forces in their environment. The force is believed to initially affect the plasma membrane and then alter the behavior of membrane proteins. Phospholipas
Externí odkaz:
https://doaj.org/article/cca19ceafd0f4bda82ed3c895c620453
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Mechanosensation by biological membranes can be relayed by mechanical tension to ion channels. Here the authors show that phospholipase D (PLD) is activated by mechanical disruption of lipid rafts which allows PLD to mix with its substrate in the lip
Externí odkaz:
https://doaj.org/article/ef25fc0a4a2e402685b431a30b4dbb41
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Anesthetics are used every day in thousands of hospitals to induce loss of consciousness, yet scientists and the doctors who administer these compounds lack a molecular understanding for their action. The chemical properties of anestheti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff847c745931da1549c6a98edb5ded5
http://europepmc.org/articles/PMC7306821
http://europepmc.org/articles/PMC7306821
Autor:
Andrew S. Hansen, Hae-Won Chung, Scott B. Hansen, Cerrone Cabanos, Mahmud Arif Pavel, E. Nicholas Petersen, Keith R. Murphy, William W. Ja
Publikováno v:
Journal of Molecular Biology. 431:196-209
Despite the widespread consumption of ethanol, mechanisms underlying its anesthetic effects remain uncertain. n-Alcohols induce anesthesia up to a specific chain length and then lose potency-an observation known as the "chain-length cutoff effect." T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86756f7f3227910eb544e1f3bc5b9113
https://doi.org/10.1016/j.jmb.2018.11.028
https://doi.org/10.1016/j.jmb.2018.11.028
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
We thank van Swinderen and Hines (1) for their response to our recent article, where we find that anesthetics disrupt lipid rafts and activate phospholipase D (PLD) through a membrane-mediated mechanism (2). Here we take the opportunity to address so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18888490ef47728ab7f2639c971607e
https://europepmc.org/articles/PMC7547279/
https://europepmc.org/articles/PMC7547279/
Akademický článek
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Publikováno v:
Biochim Biophys Acta Biomembr
TWIK related K+ channel (TREK-1) is a mechano- and anesthetic sensitive channel that when activated attenuates pain and causes anesthesia. Recently the enzyme phospholipase D2 (PLD2) was shown to bind to the channel and generate a local high concentr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abadbed4dd930933e315289ea39110a9
https://pubmed.ncbi.nlm.nih.gov/31672538
https://pubmed.ncbi.nlm.nih.gov/31672538
Autor:
William Ja, Mahmud Arif Pavel, Manasa Gudheti, E. Nicholas Petersen, Scott B. Hansen, Erik M. Jorgensen, Keith R. Murphy
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cce689957e781bbde3b097f3f4c36487
https://doi.org/10.1096/fasebj.2019.33.1_supplement.797.6
https://doi.org/10.1096/fasebj.2019.33.1_supplement.797.6
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16aed77ee735356442adf94225449cc9
https://doi.org/10.1096/fasebj.2019.33.1_supplement.797.2
https://doi.org/10.1096/fasebj.2019.33.1_supplement.797.2
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed4235f4db3e84a97b455c81007b9086
https://doi.org/10.1096/fasebj.2019.33.1_supplement.797.4
https://doi.org/10.1096/fasebj.2019.33.1_supplement.797.4