Zobrazeno 1 - 10
of 20
pro vyhledávání: '"E. N. Timofeev"'
Publikováno v:
Biophysics. 62:207-213
A individual approach to the treatment of cancer patients, which takes the genetic features of the patient’s metabolism into account, allows one to choose an appropriate drug and its dose, that increases the efficiency of therapy and prevents the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::090356e4694255a7d42999a285a5a7a3
https://doi.org/10.1134/s0006350917020270
https://doi.org/10.1134/s0006350917020270
Autor:
S A, Lapa, K S, Romashova, M A, Spitsyn, V E, Shershov, V E, Kuznetsova, T O, Guseinov, O A, Zasedateleva, S P, Radko, E N, Timofeev, A V, Lisitsa, A V, Chudinov
Publikováno v:
Molekuliarnaia biologiia. 52(6)
A modification of the enzymatic method for the preparation of combinatorial random DNA libraries, which combines amplification in isolated microvolumes with the simultaneous incorporation of modified nucleotides and subsequent separation of DNA stran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e3c085cc8fd2bf007aa5231b35171e54
https://pubmed.ncbi.nlm.nih.gov/30633241
https://pubmed.ncbi.nlm.nih.gov/30633241
Autor:
A V, Chudinov, Y Y, Kiseleva, V E, Kuznetsov, V E, Shershov, M A, Spitsyn, T O, Guseinov, S A, Lapa, E N, Timofeev, A I, Archakov, A V, Lisitsa, S P, Radko, A S, Zasedatelev
Publikováno v:
Molekuliarnaia biologiia. 51(3)
Here, we describe the synthesis and purification of six deoxyuridine triphosphate derivatives that contain protein-like functional groups and alkene linkers of various lengths. Using KOD XL and Deep Vent polymerases, these derivatives have been incor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4e0a23d2e12838dd394cde476320459b
https://pubmed.ncbi.nlm.nih.gov/28707670
https://pubmed.ncbi.nlm.nih.gov/28707670
Publikováno v:
Russian Journal of Bioorganic Chemistry. 36:528-531
Oligonucleotide analogues containing one or a few glycine, L-, and D-alanine residues instead of phosphodiester internucleotide linkages were synthesized (C3′-NH-C(O)-CH(X)-NH-C(O)-C4′, where X = H, (S)-CH3, and (R)-CH3. The stability of the dupl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d4e3b95f53208b9a5e4308527b4ebe0
https://doi.org/10.1134/s1068162010040138
https://doi.org/10.1134/s1068162010040138
Publikováno v:
Russian Journal of Bioorganic Chemistry. 34:201-206
The synthesis of oligonucleotides containing 1-(2-deoxy-beta-D-ribofuranosyl)-2-methyl-4-nitroindole and 1-(2-deoxy-beta-D-ribofuranosyl)-2-phenyl-4-nitroindole is described. The synthesized modified oligonucleotides were used for studying the stabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ff64d87181514229b08cf2f048afdb
https://doi.org/10.1134/s106816200802009x
https://doi.org/10.1134/s106816200802009x
Publikováno v:
Scopus-Elsevier
Oligonucleotide analogues bearing an acyclocytidine linked to thymidine by an amide (3'-O-CH2-CO-N-5') bond were synthesized. Melting curves of duplexes formed by modified oligonucleotides and complementary natural oligomers were obtained and thermod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a891089cfb1e5fe1ed2925b87c457ba
https://doi.org/10.1134/s1068162008020106
https://doi.org/10.1134/s1068162008020106
Publikováno v:
Scopus-Elsevier
A method for the synthesis of 5'-deoxy-5'-ethoxycarbonylmethyl nucleosides has been developed. 3-O-Benzyloxymethyl-1,2-O-isopropylidene-alpha-D-allofuranose was oxidized by sodium periodate to form a 5-aldo derivative, which was converted by the reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65492132aefd3893dc4d241f960b67d
https://pubmed.ncbi.nlm.nih.gov/19915643
https://pubmed.ncbi.nlm.nih.gov/19915643
Publikováno v:
Scopus-Elsevier
An improved method for the synthesis of 3-deoxy-3-carboxymethylnucleosides was suggested. Oxidation of 5-O-benzoyl-l,2-O-isopropylidene-alpha-D-xylofuranose resulted in the 3-keto derivative, which was treated with triethylphosphonoacetate in the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58f98cb0e6b4d4e8370f405962e0538
https://pubmed.ncbi.nlm.nih.gov/19377525
https://pubmed.ncbi.nlm.nih.gov/19377525
Publikováno v:
Molekuliarnaia biologiia. 38(3)
Binding of short fluorescently labeled AT-containing DNA duplexes with modified oligocytidylates is studied. The latter are modified to contain unnatural alpha-anomers along with natural beta-nucleotides; the nucleotide composition is selected accord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::697516317771dfcc074015e4214d0e5c
https://pubmed.ncbi.nlm.nih.gov/15285625
https://pubmed.ncbi.nlm.nih.gov/15285625
Publikováno v:
Molekuliarnaia biologiia. 36(1)
We studied the properties of DNA duplexes containing 5-nitroindole (N) in one of the chains. We synthesized 8-membered oligos with N at the 5' or at the 3' end: 5'-d(NXGACCGTC)-3' or 5'-d(GACCGTCXN)-3', where X is one of the four natural bases, makin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ccf37352544cef4c572a660ad93b1cd3
https://pubmed.ncbi.nlm.nih.gov/11862706
https://pubmed.ncbi.nlm.nih.gov/11862706