Zobrazeno 1 - 10
of 81
pro vyhledávání: '"E. Modi"'
Autor:
Maya Chopra, Meera E. Modi, Kira A. Dies, Nancy L. Chamberlin, Elizabeth D. Buttermore, Stephanie Jo Brewster, Lisa Prock, Mustafa Sahin
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 32-46 (2022)
Interest in gene-based therapies for neurodevelopmental disorders is increasing exponentially, driven by the rise in recognition of underlying genetic etiology, progress in genomic technology, and recent proof of concept in several disorders. The cur
Externí odkaz:
https://doaj.org/article/b06707dc5eda41d08b9202717d7435f6
Autor:
Meera E. Modi, Katayoun Derakhchan, Christopher T. Winkelmann, Elizabeth J. Galbreath, David E. Ehmann
Publikováno v:
Molecular Genetics and Metabolism. 138:107227
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca8ae069c78f256b45f3cc5dc9d8dac1
https://doi.org/10.1016/j.ymgme.2022.107227
https://doi.org/10.1016/j.ymgme.2022.107227
Autor:
Meera E. Modi, Natalia Boukharov, Kristin Tonini, Nancy Paz, Mary R. Alessandrini, Kartik Shah, Eric Park, Rizwana Islam
Publikováno v:
Molecular Genetics and Metabolism. 138:107226
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a5dfb448a8eff36bdc47fc8f81456c2
https://doi.org/10.1016/j.ymgme.2022.107226
https://doi.org/10.1016/j.ymgme.2022.107226
Autor:
Mustafa Sahin, Meera E. Modi
Publikováno v:
Neuron. 106:359-361
Dysregulation of the PI3K/Akt/mTOR pathway has become a point of convergence in autism spectrum disorder (ASD). In this issue of Neuron, Tai et al. (2020) identify a therapeutic role for tau reduction in downregulating this pathway and ameliorating A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17ee49b765e7952bf88b3edbdca7e033
https://doi.org/10.1016/j.neuron.2020.04.019
https://doi.org/10.1016/j.neuron.2020.04.019
Autor:
Michael. G. Mariscal, Elizabeth Berry-Kravis, Joseph D. Buxbaum, Lauren E. Ethridge, Rajna Filip-Dhima, Jennifer H. Foss-Feig, Alexander Kolevzon, Meera. E. Modi, Matthew W. Mosconi, Charles A. Nelson, Craig M. Powell, Paige M. Siper, Latha Soorya, Andrew Thaliath, Audrey Thurm, Bo Zhang, Mustafa Sahin, April R. Levin, the Developmental Synaptopathies Consortium
Publikováno v:
Molecular Autism
Molecular Autism, Vol 12, Iss 1, Pp 1-12 (2021)
Molecular Autism, Vol 12, Iss 1, Pp 1-12 (2021)
Background Phelan-McDermid Syndrome (PMS) is a rare condition caused by deletion or mutation of the SHANK3 gene. Individuals with PMS frequently present with intellectual disability, autism spectrum disorder, and other neurodevelopmental challenges.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca944f0c95d3506eab40d8934594b015
http://europepmc.org/articles/PMC8082621
http://europepmc.org/articles/PMC8082621
Autor:
Michael. G. Mariscal, Berry-Kravis, Elizabeth, Buxbaum, Joseph D., Ethridge, Lauren E., Filip-Dhima, Rajna, Foss-Feig, Jennifer H., Kolevzon, Alexander, Meera. E. Modi, Mosconi, Matthew W., Nelson, Charles A., Powell, Craig M., Siper, Paige M., Soorya, Latha, Thaliath, Andrew, Thurm, Audrey, Zhang, Bo, Sahin, Mustafa, Levin, April R.
Additional file 1. Supplementary Table 1. Group comparisons for power in each frequency band, and phase-amplitude coupling metrics. Median values (25th and 75th percentile values in parentheses) are presented for each category. All tests performed us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9349b56410dd57c6a8e8633d17f6a8
Autor:
Charles A. Nelson, Mustafa Sahin, Laurie Bayet, Amanda O’Brien, Meera E. Modi, Katherine D. Riley
Publikováno v:
Frontiers in Integrative Neuroscience
Frontiers in Integrative Neuroscience, Vol 14 (2020)
Frontiers in Integrative Neuroscience, Vol 14 (2020)
Individuals with Tuberous Sclerosis Complex (TSC) have atypical white matter integrity and neural connectivity in the brain, including language pathways. To explore functional activity associated with auditory and language processing in individuals w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1748c47c3272e8151efac630f974d05
http://europepmc.org/articles/PMC7161665
http://europepmc.org/articles/PMC7161665
Autor:
Stephen H.T. Lammers, Chloe E. Super, Hannah Purtell, Elizabeth Bainbridge, Sameer C. Dhamne, Meera E. Modi, Mustafa Sahin, Sarika Gurnani, Alexander Rotenberg, Mustafa Q. Hameed, Ervin L. Johnson
Publikováno v:
Epilepsy Behav
High-voltage rhythmic electroencephalographic (EEG) spikes have been recorded in wildtype (WT) rats during periods of light slow-wave sleep and passive wakefulness. The source of this activity is unclear but has been attributed to either an inherent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa68bf8ce9ddaac9a5317f41e9e2f53
https://doi.org/10.1016/j.yebeh.2018.09.003
https://doi.org/10.1016/j.yebeh.2018.09.003
The Way Forward for Mechanism-Based Therapeutics in Genetically Defined Neurodevelopmental Disorders
Autor:
Meera E. Modi, Mustafa Sahin
Publikováno v:
Clinical Pharmacology & Therapeutics. 104:603-606
Rare genetically defined neurodevelopmental disorders with increased risk of autism have recently become an entry point for autism-related drug discovery. Through exploration of downstream effects of the pathological mutations, specific mechanistic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e48bd250e4a19982a89b8485904a669
https://doi.org/10.1002/cpt.1181
https://doi.org/10.1002/cpt.1181
Autor:
Elyza Kelly, Jonathan O. Lipton, Samantha M. Schaeffer, Stephen H.T. Lammers, Jill L. Silverman, Chloe E. Super, Lothar Lindemann, Alexander Rotenberg, John R. Dreier, Meera E. Modi, Mustafa Sahin, Michael Honer, Sameer C. Dhamne, David J. Kwiatkowski, Georg Jaeschke
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol 43, iss 6
Drugs targeting metabotropic glutamate receptor 5 (mGluR5) have therapeutic potential in autism spectrum disorders (ASD), including tuberous sclerosis complex (TSC). The question whether inhibition or potentiation of mGluR5 could be beneficial depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3afe43df944198059452f4ac8ac6fa
https://doi.org/10.1038/npp.2017.295
https://doi.org/10.1038/npp.2017.295