Zobrazeno 1 - 10
of 43
pro vyhledávání: '"E. Michael Gibbs"'
Autor:
H. James Harwood, Jr., Stephen F. Petras, Dennis J. Hoover, Dayna C. Mankowski, Victor F. Soliman, Eliot D. Sugarman, Bernard Hulin, Younggil Kwon, E. Michael Gibbs, James T. Mayne, Judith L. Treadway
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 3, Pp 547-563 (2005)
Diabetic dyslipidemia requires simultaneous treatment with hypoglycemic agents and lipid-modulating drugs. We recently described glycogen phosphorylase inhibitors that reduce glycogenolysis in cells and lower plasma glucose in ob/ob mice (J. Med. Che
Externí odkaz:
https://doaj.org/article/5ebbe43f58a84c83843fcaee4e9c9fbd
Autor:
Ahmed E Enayetallah, Daniel Ziemek, Michael T Leininger, Ranjit Randhawa, Jianxin Yang, Tara B Manion, Dawn E Mather, William J Zavadoski, Max Kuhn, Judith L Treadway, Shelly Ann G des Etages, E Michael Gibbs, Nigel Greene, Claire M Steppan
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27009 (2011)
Triglyceride accumulation is associated with obesity and type 2 diabetes. Genetic disruption of diacylglycerol acyltransferase 1 (DGAT1), which catalyzes the final reaction of triglyceride synthesis, confers dramatic resistance to high-fat diet induc
Externí odkaz:
https://doaj.org/article/5661590c2bdc4b59b1a5d3906590a54f
Autor:
Tara B. Manion, Roberto A. Calle, Benjamin S. Maciejewski, Terrell A. Patterson, Thomas S. McDonald, Steven Watkins, Jennifer L. LaPerle, E. Michael Gibbs, Dawn Mather, Avijit Ghosh, Danny Chen, William J. Zavadoski, Claire M. Steppan, Maya Hanna
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 304:G958-G969
Alterations in fat metabolism, in particular elevated plasma concentrations of free fatty acids and triglycerides (TG), have been implicated in the pathogenesis of Type 2 diabetes, obesity, and cardiovascular disease. Acyl-CoA:diacylglycerol acyltran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58851d26674ed39fe0b3016d639d84b4
https://doi.org/10.1152/ajpgi.00384.2012
https://doi.org/10.1152/ajpgi.00384.2012
Autor:
John Litchfield, Melissa P. Andrews, Jian-Cheng Li, Jennifer L. LaPerle, Christian Perreault, Leena Patel, Karki Kapil Kumar, Michael John Munchhof, Gayatri Balan, Angel Guzman-Perez, Robert L. Dow, Gary Erik Aspnes, E. Michael Gibbs
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6122-6125
A novel series of potent DGAT-1 inhibitors was developed originating from the lactam-based clinical candidate PF-04620110. Incorporation of a dioxino[2,3-d]pyrimidine-based core afforded good alignment of pharmacophore features and resulted in improv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95ed7c4f5b938b83389ece1c1b98390
https://doi.org/10.1016/j.bmcl.2011.08.028
https://doi.org/10.1016/j.bmcl.2011.08.028
Autor:
J. Kyle Krady, Rashmi Kumari, Shyama D. Patel, Susan J. Vannucci, Lisa B. Willing, William J. Zavadoski, E. Michael Gibbs, Ian A. Simpson
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 30:352-360
Diabetes is an increased risk factor for stroke and results in increased brain damage in experimental animals and humans. The precise mechanisms are unclear, but our earlier studies in the db/db mice suggested that the cerebral inflammatory response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0806597049bb7af7e4531ebc89b378b
https://doi.org/10.1038/jcbfm.2009.221
https://doi.org/10.1038/jcbfm.2009.221
Autor:
Michael Scott Visser, Michael P. DeNinno, Melissa P. Andrews, Andrew Simon Bell, Michael John Palmer, Nan Eshelby, Cynthia Eller-Zarbo, John B. Etienne, Yue Chen, E. Michael Gibbs, William J. Zavadoski, Li J. Yu, Dianna E. Moore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2537-2541
Starting from a non-selective pyrazolo-pyrimidone lead, the sequential use of parallel medicinal chemistry and directed synthesis led to the discovery of potent, highly selective, and orally bioavailable PDE9 inhibitors. The availability of these too
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90579384bdc00653d5f3b8ed65d6fc3e
https://doi.org/10.1016/j.bmcl.2009.03.024
https://doi.org/10.1016/j.bmcl.2009.03.024
Autor:
David E. Johnson, E. Michael Gibbs, William J. Zavadoski, Karen L. Houseknecht, Hans Rollema, Alan Robertson
Publikováno v:
Neuropsychopharmacology. 32:289-297
Although it is generally accepted that atypical antipsychotics differ in their risk for diabetic side effects, the underlying pharmacological mechanisms are unknown. Studies on the mechanisms of antipsychotic-induced hyperglycemia or insulin resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5b39718f8a2dd96e8dc8e9b7cf928b
https://doi.org/10.1038/sj.npp.1301209
https://doi.org/10.1038/sj.npp.1301209
Autor:
Judith L. Treadway, Walter S. Zawalich, Hanae Yamazaki, Karen M. Ward, Wesley S. Lebel, Anne W. Schmidt, David E. Johnson, Hans Rollema, E. Michael Gibbs
Publikováno v:
Diabetes. 54:1552-1558
Treatment with the atypical antipsychotics olanzapine and clozapine has been associated with an increased risk for deterioration of glucose homeostasis, leading to hyperglycemia, ketoacidosis, and diabetes, in some cases independent of weight gain. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd9886734a54c2cb826f7f17b2f6fb43
https://doi.org/10.2337/diabetes.54.5.1552
https://doi.org/10.2337/diabetes.54.5.1552
Autor:
Thomas H. Reynolds, Ralph W. Stevenson, E. Michael Gibbs, Scott C. McCoid, Joseph T. Brozinick, Samuel W. Cushman, Diane M. Hargrove, Nancy A. Nardone
Publikováno v:
Diabetes. 50:593-600
We previously reported that overexpression of GLUT4 in lean, nondiabetic C57BL/KsJ- lepr db/+ ( db/+ ) mice resulted in improved glucose tolerance associated with increased basal and insulin-stimulated glucose transport in isolated skeletal muscle. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d02f52c96f088b1661cc016aea95428
https://doi.org/10.2337/diabetes.50.3.593
https://doi.org/10.2337/diabetes.50.3.593
Autor:
Dawn Mather, Mark Niosi, Susan Tapley, Christian Perreault, Michael John Munchhof, Angel Guzman-Perez, Jian-Cheng Li, Robert L. Dow, Melissa P. Andrews, Jennifer L. LaPerle, Leena Patel, William J. Zavadoski, Qifang Li, E. Michael Gibbs
Publikováno v:
Bioorganicmedicinal chemistry. 21(17)
DGAT-1 is an enzyme that catalyzes the final step in triglyceride synthesis. mRNA knockout experiments in rodent models suggest that inhibitors of this enzyme could be of value in the treatment of obesity and type II diabetes. The carboxylic acid-bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4dad263bd8eb51ef40984fc855a78be
https://pubmed.ncbi.nlm.nih.gov/23871442
https://pubmed.ncbi.nlm.nih.gov/23871442