Zobrazeno 1 - 10
of 73
pro vyhledávání: '"E. Michael Danielsen"'
Autor:
E. Michael Danielsen, Gert H. Hansen
Publikováno v:
Pharmaceutics, Vol 10, Iss 4, p 172 (2018)
The small intestinal epithelium constitutes a major permeability barrier for the oral administration of therapeutic drugs with poor bioavailability, and permeation enhancers (PEs) are required to increase the paracellular and/or transcellular uptake
Externí odkaz:
https://doaj.org/article/05cb3e0cde854d3c972dce052f69db36
Autor:
E Michael Danielsen, Gert H Hansen
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76661 (2013)
The small intestinal brush border has an unusually high proportion of glycolipids which promote the formation of lipid raft microdomains, stabilized by various cross-linking lectins. This unique membrane organization acts to provide physical and chem
Externí odkaz:
https://doaj.org/article/4448f9c12cf34772819e236deae47765
Autor:
E. Michael Danielsen
Publikováno v:
Biochimica et biophysica acta. Biomembranes. 1863(1)
Permeation enhancers (PEs) are compounds aimed to increase intestinal uptake of oral drugs with poor bioavailability. This mini-review focuses on results recently obtained with PEs using an intestinal organ culture model. The model predicts which par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ca843da492591700f8824e12d3a0ab
https://pubmed.ncbi.nlm.nih.gov/32946886
https://pubmed.ncbi.nlm.nih.gov/32946886
Autor:
E. Michael Danielsen, Alba De Haro Hernando, Jørgen Olsen, Mohammad Yassin, Elisabeth M. Danielsen, Gert H. Hansen, Karina Rasmussen
Publikováno v:
Danielsen, E M, De Haro Hernando, A, Yassin, M, Rasmussen, K, Olsen, J, Hansen, G H & Danielsen, E M 2020, ' Short-term tissue permeability actions of dextran sulfate sodium studied in a colon organ culture system ', Tissue Barriers, vol. 8, no. 2, 1728165 . https://doi.org/10.1080/21688370.2020.1728165
Tissue Barriers
article-version (VoR) Version of Record
Tissue Barriers
article-version (VoR) Version of Record
Dextran sulfate sodium (DSS)-induced colitis is the most commonly used animal model for inflammatory bowel diseases. However, the precise molecular action of DSS, in particular its initial effect on the epithelial tissue permeability, is still poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4011cd2d052d217e80de627f7a414d6f
https://curis.ku.dk/portal/da/publications/shortterm-tissue-permeability-actions-of-dextran-sulfate-sodium-studied-in-a-colon-organ-culture-system(b7f74e9c-5dcd-4f1c-aa35-88c4679a2169).html
https://curis.ku.dk/portal/da/publications/shortterm-tissue-permeability-actions-of-dextran-sulfate-sodium-studied-in-a-colon-organ-culture-system(b7f74e9c-5dcd-4f1c-aa35-88c4679a2169).html
Autor:
Gert H. Hansen, E. Michael Danielsen
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1860:1589-1599
“Cell penetrating peptides” (CPPs) are natural or synthetic peptides with the ability to interact with cell membranes in order to enter cells and/or deliver cargo. They attract considerable interest as permeation enhancers for oral delivery of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ded9b6a4b0326fabf80774ade75e21
https://doi.org/10.1016/j.bbamem.2018.05.015
https://doi.org/10.1016/j.bbamem.2018.05.015
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1859:360-367
Chitosan is a polycationic polysaccharide consisting of β-(1-4)-linked glucosamine units and due to its mucoadhesive properties, chemical derivatives of chitosan are potential candidates as enhancers for transmucosal drug delivery. Recently, glycol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8118818eda4334d9f413765898b642ad
https://doi.org/10.1016/j.bbamem.2016.12.017
https://doi.org/10.1016/j.bbamem.2016.12.017
Autor:
E. Michael Danielsen, Gert H. Hansen
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1858:233-243
Pinocytosis at the small intestinal brush border was studied in postweaned porcine cultured mucosal explants, using the fluorescent polar probes Alexa hydrazide (AH, MW 570), Texas red dextran (TRD, MW ~ 3000), and Cascade blue dextran (CBD, MW ~ 10,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43eec1beb50b74d8e46bc8a91746d969
https://doi.org/10.1016/j.bbamem.2015.11.022
https://doi.org/10.1016/j.bbamem.2015.11.022
Autor:
E. Michael Danielsen, Gert H. Hansen
Publikováno v:
Tissue barriers. 5(3)
Intestinal permeation enhancers (PEs) are agents aimed to improve oral delivery of therapeutic drugs with poor bioavailability. The main permeability barrier for oral delivery is the intestinal epithelium, and PEs act to increase the paracellular and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97ff6db7f0882529c17b0b7c42224f9
https://pubmed.ncbi.nlm.nih.gov/28837408
https://pubmed.ncbi.nlm.nih.gov/28837408
Autor:
E. Michael Danielsen
Publikováno v:
Histochemistry and Cell Biology. 143:545-556
The small intestinal brush border is a specialized cell membrane that needs to withstand the solubilizing effect of bile salts during assimilation of dietary nutrients and to achieve detergent resistance; it is highly enriched in glycolipids organize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250b5fcfbb7a2e4d0b5f7463e5c93e3e
https://doi.org/10.1007/s00418-014-1302-2
https://doi.org/10.1007/s00418-014-1302-2
Publikováno v:
Neurochemical Research. 40:410-419
The ability to modulate the synaptic GABA levels has been demonstrated by using the clinically effective and selective GAT1 inhibitor tiagabine [(R)-N-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid]. N-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e444b1273fed103cf48d0244960bdee5
https://doi.org/10.1007/s11064-014-1494-9
https://doi.org/10.1007/s11064-014-1494-9