Zobrazeno 1 - 10
of 710
pro vyhledávání: '"E. Merritt"'
Autor:
Marc McLeod, Mario C. Chang, Anna Rushin, Mukundan Ragavan, Rohit Mahar, Gaurav Sharma, Arshee Badar, Anthony Giacalone, Max E. Glanz, Vinay R. Malut, Dalton Graham, Nishanth E. Sunny, James A. Bankson, Kenneth Cusi, Matthew E. Merritt
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101714- (2024)
Summary: Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing annually and affects over a third of US adults. MASLD can progress to metabolic dysfunction-associated steatohepatitis (MASH), characterized by severe
Externí odkaz:
https://doaj.org/article/c5f37c219a1342b59cc8a63717b98100
Autor:
Lucia Cilenti, Jacopo Di Gregorio, Rohit Mahar, Fei Liu, Camilla T. Ambivero, Muthu Periasamy, Matthew E. Merritt, Antonis S. Zervos
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Obesity is a growing epidemic affecting millions of people worldwide and a major risk factor for a multitude of chronic diseases and premature mortality. Accumulating evidence suggests that mitochondria have a profound role in diet-induced obesity an
Externí odkaz:
https://doaj.org/article/4e9129dc645344a9b0a8a2258082e805
Autor:
Alessia Urzi, Ines Lahmann, Lan Vi N. Nguyen, Benjamin R. Rost, Angélica García-Pérez, Noemie Lelievre, Megan E. Merritt-Garza, Han C. Phan, Gary J. Bassell, Wilfried Rossoll, Sebastian Diecke, Severine Kunz, Dietmar Schmitz, Mina Gouti
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The complex neuromuscular network that controls body movements is the target of severe diseases that result in paralysis and death. Here, we report the development of a robust and efficient self-organizing neuromuscular junction (soNMJ) mode
Externí odkaz:
https://doaj.org/article/2a4b36d43f0e4127a2f6076ef4be50b5
Autor:
Marcelo Febo, Rohit Mahar, Nicholas A. Rodriguez, Joy Buraima, Marjory Pompilus, Aeja M. Pinto, Matteo M. Grudny, Adriaan W. Bruijnzeel, Matthew E. Merritt
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
IntroductionThe differential expression of emotional reactivity from early to late adulthood may involve maturation of prefrontal cortical responses to negative valence stimuli. In mice, age-related changes in affective behaviors have been reported,
Externí odkaz:
https://doaj.org/article/4f0f9079ac464cad8527bfce8c8840ff
Autor:
Stephen J. Staklinski, Mario C. Chang, Rebecca C. Ahrens‐Nicklas, Shagun Kaur, Arianna K. Stefanatos, Elizabeth E. Dudenhausen, Matthew E. Merritt, Michael S. Kilberg
Publikováno v:
JIMD Reports, Vol 64, Iss 2, Pp 167-179 (2023)
Abstract Asparagine synthetase (ASNS) catalyzes the synthesis of asparagine (Asn) from aspartate and glutamine. Biallelic mutations in the ASNS gene result in ASNS Deficiency (ASNSD). Children with ASNSD exhibit congenital microcephaly, epileptic‐l
Externí odkaz:
https://doaj.org/article/43ff810be89c4f6e9718627d28111f9a
Autor:
Rohit Mahar, Mukundan Ragavan, Mario C. Chang, Savannah Hardiman, Nissin Moussatche, Adam Behar, Rolf Renne, Matthew E. Merritt
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Oncolytic viral therapy is a recent advance in cancer treatment, demonstrating promise as a primary treatment option. To date, the secondary metabolic effects of viral infection in cancer cells has not been extensively studied. In this work,
Externí odkaz:
https://doaj.org/article/73e20652647c43a6985afe9e06614b7e
Autor:
Christopher J. Frost, Andrea Ramirez-Mata, Ram B. Khattri, Matthew E. Merritt, Susan C. Frost
Publikováno v:
PLoS ONE, Vol 18, Iss 3 (2023)
Hypoxia is a common feature of most solid tumors, one that favors tumor progression and limits treatment effectiveness. Targeting hypoxia has long been a goal in cancer therapy, by identifying factors that reverse or ameliorate the effects of hypoxia
Externí odkaz:
https://doaj.org/article/112d1d5fff75411487fee40004ef91f5
Autor:
Haichang Li, Zhongguang Li, Xiuchun Li, Chuanxi Cai, Serena Li Zhao, Robert E. Merritt, Xinyu Zhou, Tao Tan, Valerie Bergdall, Jianjie Ma
Publikováno v:
Cells, Vol 12, Iss 14, p 1915 (2023)
Sulfur mustard (SM) and nitrogen mustard (NM) are vesicant agents that cause skin injury and blistering through complicated cellular events, involving DNA damage, free radical formation, and lipid peroxidation. The development of therapeutic approach
Externí odkaz:
https://doaj.org/article/9baabc4c99314d48a190c0eae4c53a4d
Autor:
Robert E. Merritt, Peter J. Kneuertz, Mahmoud Abdel-Rasoul, Desmond M. D’Souza, Kyle A. Perry
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 16, Iss 1, Pp 1-10 (2021)
Abstract Background Locally advanced esophageal carcinoma is typically treated with neoadjuvant chemoradiation and esophagectomy (trimodality therapy). We compared the long-term oncologic outcomes of minimally invasive Ivor Lewis esophagectomy (M-ILE
Externí odkaz:
https://doaj.org/article/d63a27196a9e477abc7e23fa7def94d8
Autor:
Haichang Li, Pei-Hui Lin, Pranav Gupta, Xiangguang Li, Serena Li Zhao, Xinyu Zhou, Zhongguang Li, Shengcai Wei, Li Xu, Renzhi Han, Jing Lu, Tao Tan, Dong-Hua Yang, Zhe-Sheng Chen, Timothy M. Pawlik, Robert E. Merritt, Jianjie Ma
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-15 (2021)
Abstract Background Cancer cells develop resistance to chemotherapeutic intervention by excessive formation of stress granules (SGs), which are modulated by an oncogenic protein G3BP2. Selective control of G3BP2/SG signaling is a potential means to t
Externí odkaz:
https://doaj.org/article/927f7bde79de4345b15b1de3d3bbb033