Zobrazeno 1 - 10 of 103 pro vyhledávání: '"E. Menta"'
1
Synthesis and Antitumor Evaluation of 2,5-Disubstituted- Indazolo[4,3-gh]isoquinolin-6(2H)-ones (9-Aza-anthrapyrazoles)
Autor: L. Fiocchi, G. Pezzoni, C. E. Gallagher, E. Menta, A. P. Krapcho, M E Maresch, S. Spinelli, Miles P. Hacker, R. Di Domenico, F. C. Giuliani, Ambrogio Oliva, Gino Beggiolin
Publikováno v: Journal of Medicinal Chemistry. 41:5429-5444
The synthesis and antitumor evaluation of 2, 5-disubstituted-indazolo[4,3-gh]isoquinolin-6(2H)-ones (9-aza-APs) are described. The key intermediates in the synthesis are benz[g]isoquinoline-5,10-diones which are substituted at positions 6 and 9 with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde1964c6a22c73d81575db2417cb361
https://doi.org/10.1021/jm9804432
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2
N-Acyl-2-substituted-1,3-thiazolidines, a new class of non-narcotic antitussive agents: studies leading to the discovery of ethyl 2-[(2-methoxyphenoxy)methyl]-.beta.-oxothiazolidine-3-propanoate
Autor: Licia Gallico, E. Menta, Dalla Rosa C, L. Fiocchi, S. Spinelli, Gandolfi Carmelo A, Sergio Tognella, A. Lotto, Di Domenico R, A. Borghi
Publikováno v: Journal of Medicinal Chemistry. 38:508-525
The synthesis of a novel class of antitussive agents is described. The compounds were examined for antitussive activity in guinea pig after cough induction by electrical or chemical stimulation. Ethyl 2-[(2-methoxyphenoxy)methyl]-beta-oxothiazolidine
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591a41d9c273aa7501dbd32422fcd688
https://doi.org/10.1021/jm00003a014
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8
Pyrimidine-2,4,6-Triones: A New Effective and Selective Class of Matrix Metalloproteinase Inhibitors
Autor: F, Grams, H, Brandstetter, S, D'Alò, D, Geppert, H W, Krell, H, Leinert, V, Livi, E, Menta, A, Oliva, G, Zimmermann, F, Gram, E, Livi VMenta
Publikováno v: Biological Chemistry. 382
Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that have been implicated in various disease processes. Different classes of MMP inhibitors, including hydroxamic acids, phosphinic acids and thiols, have been previously described.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b5b7992074398f8ef740a9d5e62a00
https://doi.org/10.1515/bc.2001.159
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9
BBR 3464: a novel triplatinum complex, exhibiting a preclinical profile of antitumor efficacy different from cisplatin
Autor: C, Manzotti, G, Pratesi, E, Menta, R, Di Domenico, E, Cavalletti, H H, Fiebig, L R, Kelland, N, Farrell, D, Polizzi, R, Supino, G, Pezzoni, F, Zunino
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(7)
Multinuclear platinum complexes represent a new class of anticancer agents, distinct in terms of DNA binding features and the profile of antitumor activity from their mononuclear counterparts, in particular cisplatin. Among complexes of this class, B
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b51e58b96cef850b2470634d9451d2b
https://pubmed.ncbi.nlm.nih.gov/10914703
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10
Cytotoxicity, cellular uptake and DNA binding of the novel trinuclear platinun complex BBR 3464 in sensitive and cisplatin resistant murine leukemia cells
Autor: P, Di Blasi, A, Bernareggi, G, Beggiolin, L, Piazzoni, E, Menta, M L, Formento
Publikováno v: Anticancer research. 18(4C)
BBR 3464 is a novel trinuclear platinum anticancer agent designed on the hypothesis that new clinically useful platinum based anticancer agents should have novel structures unrelated to those of agents currently used in the clinic. BBR 3464 shows out
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f4cbf94244da6a17948a519a48dcc286
https://pubmed.ncbi.nlm.nih.gov/9713519
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