Zobrazeno 1 - 10
of 28
pro vyhledávání: '"E. Martin Fielden"'
Autor:
John Nolan, E. Martin Fielden, Matthew A. Naylor, Peter O'Neill, Bridget M. Sutton, Gerald E. Adams, Ian J. Stratford
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 29:333-337
To study the reduction of RB90740 (1), a fused pyrazine mono-N-oxide that has an oxic:hypoxic cytotoxicity ratio of10 in a range of murine and human tumor cells in vitro.Reduction of 1 has been initiated radiolytically and photochemically in aqueous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7d4b3b0d1259c7b551fe638408fb35
https://doi.org/10.1016/0360-3016(94)90285-2
https://doi.org/10.1016/0360-3016(94)90285-2
Autor:
Bridget M. Sutton, Gerald E. Adams, Nigel J. Reeves, S. Cole, E. Martin Fielden, Matthew A. Naylor, Ian J. Stratford
Publikováno v:
International journal of radiation oncology, biology, physics. 29(2)
Purpose: 1,2-Dihydro-8-(4-methylpiperazinyl)-4-phenylimidazo [1,2- a ] pyrido [3,2- e ] pyrazine-5-oxide (RB90740) is a bioreductive drug with an oxic to hypoxic toxicity ratio of 16 in cultured V79 cells in vitro . The aim of this study was to exami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096248c9c4b21f0e8bda7775fda13cc1
https://pubmed.ncbi.nlm.nih.gov/8195030
https://pubmed.ncbi.nlm.nih.gov/8195030
Autor:
E. Martin Fielden, Peter O'Neill
Publisher Summary This chapter discusses the primary free radical processes in DNA following the initial spatial distribution of energy deposition. In an attempt to characterize the DNA radicals formed within microseconds of irradiation, the transien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d6f5b9f4031c95c4f9dbe5ee7099857
https://doi.org/10.1016/b978-0-12-035417-7.50005-2
https://doi.org/10.1016/b978-0-12-035417-7.50005-2
Publikováno v:
Radiation Research. 121:149
The "in-pulse" luminescence emission from solid DNA produced upon irradiation with electron pulses of energy below 260 keV has been investigated in vacuo at 293 K to gain an insight into the existence of radiation-induced charge/energy migration with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28683bb110f44903809e9627d2f61d42
https://doi.org/10.2307/3577497
https://doi.org/10.2307/3577497
Autor:
Gillian N. Mautner, Peter B. Roberts, E. Martin Fielden, Giuseppe Rotilio, David J. Lowe, Lilia Calabrese, Robert C. Bray
Publikováno v:
Biochemical Journal. 139:49-60
1. Detailed studies on the mechanism of the enzymic reaction of bovine superoxide dismutase were carried out by using pulse radiolysis and electron paramagnetic resonance (e.p.r.). 2. The second-order rate constant for reaction between superoxide dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de32795f83a0618352b8ae0859b70ab
https://doi.org/10.1042/bj1390049
https://doi.org/10.1042/bj1390049
Autor:
G. Rotilio, Donatella Barra, E. Martin Fielden, Peter B. Roberts, Lilia Calabrese, Francesco Bossa
Publikováno v:
Biochemical and Biophysical Research Communications. 64:1303-1309
Amino acid analyses of irradiated bovine superoxide dismutase solutions showed that only a few types of residues are destroyed by H and Br 2 − radicals and confirmed the indications obtained from work on free amino acids. Furthermore destruction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12a60b9813eebd9db11a188856462b3
https://doi.org/10.1016/0006-291x(75)90834-7
https://doi.org/10.1016/0006-291x(75)90834-7
Publikováno v:
Biochemical Society Transactions. 1:1067-1072
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ce02fd4d405a2175fee86c34ffd6a14
https://doi.org/10.1042/bst0011067a
https://doi.org/10.1042/bst0011067a
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Enzymology. 268:605-609
The superoxide dismutase activity of bovine erythrocuprein has been studied by pulse radiolysis under steady-state and pre-steady-state conditions. Enzyme activity is independent of pH in the range 5.3 to 9.5. Cyanide inhibits the enzyme, indicating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9b6ac4f852161c4d8007390b1b35ab
https://doi.org/10.1016/0005-2744(72)90359-2
https://doi.org/10.1016/0005-2744(72)90359-2
Autor:
Orazio Sapora, E. Martin Fielden
Publikováno v:
Advanced Topics on Radiosensitizers of Hypoxic Cells ISBN: 9781475704013
Chromosomal deoxyribonucleic acid (DNA) is accepted as an important target for radiochemical damage in biological systems following ultraviolet and ionizing irradiation. Several types of experimental data support this hypothesis for numerous biologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2b2d8f71861a8e7d253077a743708d8
https://doi.org/10.1007/978-1-4757-0399-3_5
https://doi.org/10.1007/978-1-4757-0399-3_5
Publikováno v:
Radiation research. 70(3)
JOHANSEN, I., GULBRANDSEN, R., FIELDEN, E. M., AND SAPORA, O. Additive Effects Shown by Combinations of Nitroxyl and Electron-Affinic Hypoxic Cell Sensitizers. Radiat. Res. 70, 597-603 (1977). Nitroxyl free radical sensitizers enhance the radiation k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b34459aee3372e2943c52e3e482d39
https://pubmed.ncbi.nlm.nih.gov/327503
https://pubmed.ncbi.nlm.nih.gov/327503