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Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

Autor: I. Plastira, E. Bernhart, M. Goeritzer, T. DeVaney, H. Reicher, A. Hammer, B. Lohberger, A. Wintersperger, B. Zucol, W. F. Graier, D. Kratky, E. Malle, W. Sattler

Publikováno v: Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-28 (2017)

Abstract Background Extracellular lysophosphatidic acid (LPA) species transmit signals via six different G protein-coupled receptors (LPAR1–6) and are indispensible for brain development and function of the nervous system. However, under neuroinfla

Externí odkaz: https://doaj.org/article/275bdff4de584594a8741445fdbfe635

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Akademický článek

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Akademický článek

Implications of endogenous and exogenous lipoprotein lipase for the selective uptake of HDL3-associated cholesteryl esters by mouse peritoneal macrophages

Autor: U Panzenboeck, A Wintersberger, S Levak-Frank, R Zimmermann, R Zechner, G M Kostner, E Malle, W Sattler

Publikováno v: Journal of Lipid Research, Vol 38, Iss 2, Pp 239-253 (1997)

To investigate the implications of endogenous LPL on selective uptake of HDL3-associated cholesteryl esters (HDL3-CEs) by mouse peritoneal macrophages (MPMs), we have performed uptake experiments with MPMs obtained from control mice and transgenic kn

Externí odkaz: https://doaj.org/article/d4a0ee7e03cd4615821336c618afe04e

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Akademický článek

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Akademický článek

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Cardioprotective effects of 5-hydroxymethylfurfural mediated by inhibition of L-type Ca

Autor: G, Wölkart, A, Schrammel, C N, Koyani, S, Scherübel, K, Zorn-Pauly, E, Malle, B, Pelzmann, M, Andrä, A, Ortner, B, Mayer

Publikováno v: British Journal of Pharmacology

Background and Purpose The antioxidant 5‐hydroxymethylfurfural (5‐HMF) exerts documented beneficial effects in several experimental pathologies and is currently tested as an antisickling drug in clinical trials. In the present study, we examined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d36b765b53236469ce5e86a67774ada
https://pubmed.ncbi.nlm.nih.gov/28768052

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Additional file 4: Figure S4. of Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

Autor: I. Plastira, E. Bernhart, M. Goeritzer, T. DeVaney, H. Reicher, A. Hammer, B. Lohberger, A. Wintersperger, B. Zucol, W. Graier, D. Kratky, E. Malle, W. Sattler

TCLPA5 inhibits the phosphorylation of pro-inflammatory transcription factors. BV-2 microglia cells were cultured in 6-well plates and serum-starved overnight. Cells were treated with LPA (1 μM) or LPA (1 μM) in the presence of (A) TCLPA5 (5 μM) f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::038c41818bc9280da15f894364d5e682

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Additional file 6: Figure S6. of Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

Autor: I. Plastira, E. Bernhart, M. Goeritzer, T. DeVaney, H. Reicher, A. Hammer, B. Lohberger, A. Wintersperger, B. Zucol, W. Graier, D. Kratky, E. Malle, W. Sattler

PKD family members control the secretion of pro-inflammatory cytokines and chemokines. BV-2 cells were cultured on 12-well plates; serum-starved o/n and the supernatants were collected after incubation with DMSO, DMSO plus LPA (1 μM) or LPA (1 μM)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eccd9574d82dfc20c4f584c668e149c2

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Additional file 3: Figure S3. of Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

Autor: I. Plastira, E. Bernhart, M. Goeritzer, T. DeVaney, H. Reicher, A. Hammer, B. Lohberger, A. Wintersperger, B. Zucol, W. Graier, D. Kratky, E. Malle, W. Sattler

LPA promotes activation of pro-inflammatory transcription factors in BV-2 cells. Serum-starved (A) BV-2 cells were treated with 0.1% BSA (control) or LPA (1 μM) for the indicated time periods, the cellular protein lysates were collected and phosphor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b8b625a41bb2501c037d35893fad550

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Additional file 5: Figure S5. of Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

Autor: I. Plastira, E. Bernhart, M. Goeritzer, T. DeVaney, H. Reicher, A. Hammer, B. Lohberger, A. Wintersperger, B. Zucol, W. Graier, D. Kratky, E. Malle, W. Sattler

The phosphorylation of pro-inflammatory transcription factors is under PKD family control. BV-2 cells, serum-starved overnight and treated with LPA (1 μM) or LPA (1 μM) in the presence of (A) CRT0066101 (1 μM) for the indicated time periods. Cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c2002f48134aa1aa2f2890b533f58fe

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