Výsledky vyhledávání - "E. M. Twiddy"

Characterization of monoclonal antibodies that react with unique and cross-reacting determinants of cholera enterotoxin and its subunits

Autor: R K Holmes, E M Twiddy

Publikováno v: Infection and Immunity. 42:914-923

Seventeen selected hybridoma cell lines that produced monoclonal antibodies against cholera enterotoxin (CT) were isolated and characterized. All of the monoclonal antibodies contained the kappa light chain; 14 were of the immunoglobulin G1 (IgG1) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa746171fc1ce65ade3a8c34b1065277
https://doi.org/10.1128/iai.42.3.914-923.1983

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Characterization of monoclonal antibodies to heat-labile enterotoxin encoded by a plasmid from a clinical isolate of Escherichia coli

Autor: Randall K. Holmes, B W Belisle, E M Twiddy

Publikováno v: Infection and Immunity. 43:1027-1032

Eight selected hybridoma cell lines that produced monoclonal antibodies against heat-labile enterotoxin from an Escherichia coli strain of human origin (LTh) were characterized. Antibodies produced by these cell lines were tested for binding specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4122ce181938240333665f662e73c5c2
https://doi.org/10.1128/iai.43.3.1027-1032.1984

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Synthesis of plasmid-coded heat-labile enterotoxin in wild-type and hypertoxinogenic strains of Escherichia coli and in other genera of Enterobacteriaceae

Autor: R. J. Neill, E. M. Twiddy, Randall K. Holmes

Publikováno v: Infection and Immunity. 41:1056-1061

The effect of host determinants on expression of plasmid-coded heat-labile enterotoxin (LT) was examined. A collection of LT plasmids was introduced into isogenic strains of Escherichia coli K-12 strains containing the wild type or hypertoxinogenic (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9181e5d2ec073a0d4487af6ff243d42a
https://doi.org/10.1128/iai.41.3.1056-1061.1983

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Production of type II heat-labile enterotoxin by Escherichia coli isolated from food and human feces

Autor: Richard L. Guerrant, A A Lima, Randall K. Holmes, Beatriz E. C. Guth, Luiz Rachid Trabulsi, C L Pickett, E M Twiddy, B D Franco, Tânia A. T. Gomes

Publikováno v: Europe PubMed Central

Escherichia coli strains isolated in Sao Paulo, Brazil, from feces of patients with diarrhea and from food samples produced toxin(s) that was shown to be related both immunologically and genetically to the recently characterized type II heat-labile e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3c7e55d537d799d36c02683acf2928
https://doi.org/10.1128/iai.54.2.587-589.1986

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Variation in chemical properties and antigenic determinants among type II heat-labile enterotoxins of Escherichia coli

Autor: R. K. Holmes, Beatriz E. C. Guth, E M Twiddy, Luiz Rachid Trabulsi

Type II heat-labile enterotoxin (LT-II) from Escherichia coli 41 was purified and compared with prototype LT-II encoded by genes from E. coli SA53. Both toxins were oligomeric proteins consisting of polypeptides A (Mr, 28,000) and B (Mr, 11,800). The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41bc8696b4a2ceb526311399dac8a81
https://europepmc.org/articles/PMC260193/

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Monoclonal antibodies with an expanded repertoire of specificities and potent neutralizing activity for Escherichia coli heat-labile enterotoxin

Autor: Randall K. Holmes, B W Belisle, E M Twiddy

Nine selected hybridoma cell lines that produced monoclonal antibodies against the heat-labile enterotoxin encoded by a plasmid from an Escherichia coli strain of human origin (LTh) were characterized. Hybridomas that produced anti-LTh antibodies wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b267c6c3c9f84c93321c6bef868d5f2f
https://europepmc.org/articles/PMC261610/

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Comparison of the carbohydrate-binding specificities of cholera toxin and Escherichia coli heat-labile enterotoxins LTh-I, LT-IIa, and LT-IIb

Autor: S Fukuta, E M Twiddy, John L. Magnani, Victor Ginsburg, R K Holmes

The heat-labile enterotoxins of Vibrio cholerae and Escherichia coli are related in structure and function. They are oligomers consisting of A and B polypeptide subunits. They bind to gangliosides, and they activate adenylate cyclase. The toxins form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9c4cbc1e86d8bd8363ba04caa8fbd1
https://europepmc.org/articles/PMC259472/

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Purification and characterization of type II heat-labile enterotoxin of Escherichia coli

Autor: E M Twiddy, Randall K. Holmes, C L Pickett

Type II heat-labile enterotoxin (LT-II) of Escherichia coli has several biologic activities similar to cholera toxin (CT) and E. coli type I heat-labile enterotoxin (LT-I), but it is not neutralized by antiserum prepared against CT or LT-I. LT-II was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4a0384620e1475f50bfd86b0cb909a
https://europepmc.org/articles/PMC260812/

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