Mathematical Model of Hepatitis B Virus With Effect of Vaccination and Treatments

Autor: Saif H. Elkhadir, Ali E. M. Saeed, Abdelfatah Abasher

Publikováno v: International Journal of Analysis and Applications, Vol 20, Pp 53-53 (2022)

In this paper, a mathematical model of hepatitis B virus with vaccination and treatments is studied, Stability analysis discussed and the disease-free equilibrium and endemic equilibrium points obtained, the basic reproductive number R0 determined an

Externí odkaz: https://doaj.org/article/f72d83f2500c4fc1b108f749a8cc8811

Xylochemical Synthesis and Biological Evaluation of Shancigusin C and Bletistrin G

Autor: Leander Geske, Ulrich Kauhl, Mohamed E. M. Saeed, Anja Schüffler, Eckhard Thines, Thomas Efferth, Till Opatz

Publikováno v: Molecules, Vol 26, Iss 11, p 3224 (2021)

The biological activities of shancigusin C (1) and bletistrin G (2), natural products isolated from orchids, are reported along with their first total syntheses. The total synthesis of shancigusin C (1) was conducted by employing the Perkin reaction

Externí odkaz: https://doaj.org/article/ee3cff6e205f45be9168ced622b4541f

Betulinic Acid Exerts Cytotoxic Activity Against Multidrug-Resistant Tumor Cells via Targeting Autocrine Motility Factor Receptor (AMFR)

Autor: Mohamed E. M. Saeed, Nuha Mahmoud, Yoshikazu Sugimoto, Thomas Efferth, Heba Abdel-Aziz

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Betulinic acid (BetA) is a naturally occurring pentacyclic triterpene isolated from the outer bark of white-barked birch trees and many other medicinal plants. Here, we studied betulinic acid's cytotoxic activity against drug-resistant tumor cell lin

Externí odkaz: https://doaj.org/article/2e63aae3d82b4776903432f59075cc1c

Biomarker Expression Profiling in Cervix Carcinoma Biopsies Unravels WT1 as a Target of Artesunate

Autor: MOHAMED E. M. SAEED, CANDELA CIVES-LOSADA, THOMAS EFFERTH

Publikováno v: Cancer Genomics Proteomics

Background/Aim: Artemisinin and its derivatives are not only approved antimalarial drugs but also exert strong anticancer activity. Based on the clinical activity of artesunate (ART) that has been previously reported in cervix carcinoma, we investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49565fd6a4795685f87354022cb9a11f
https://europepmc.org/articles/PMC9620444/

In Silico and In Vitro Screening of 50 Curcumin Compounds as EGFR and NF-κB Inhibitors

Autor: Mohamed E. M. Saeed, Rümeysa Yücer, Mona Dawood, Mohamed-Elamir F. Hegazy, Assia Drif, Edna Ooko, Onat Kadioglu, Ean-Jeong Seo, Fadhil S. Kamounah, Salam J. Titinchi, Beatrice Bachmeier, Thomas Efferth

Publikováno v: Saeed, M E M, Yücer, R, Dawood, M, Hegazy, M E F, Drif, A, Ooko, E, Kadioglu, O, Seo, E J, Kamounah, F S, Titinchi, S J, Bachmeier, B & Efferth, T 2022, ' In Silico and In Vitro Screening of 50 Curcumin Compounds as EGFR and NF-κB Inhibitors ', International Journal of Molecular Sciences, vol. 23, no. 7, 3966 . https://doi.org/10.3390/ijms23073966
International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3966

The improvement of cancer chemotherapy remains a major challenge, and thus new drugs are urgently required to develop new treatment regimes. Curcumin, a polyphenolic antioxidant derived from the rhizome of turmeric (Curcuma longa L.), has undergone e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e462bad39757f176c45413be4a0d5c8f
https://pubmed.ncbi.nlm.nih.gov/35409325