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Autor:
Ghassan K. Abou-Alfa, E. M. O' Reilly, Herbert Hurwitz, S. G. Eckhardt, W. G. Harker, Manuel Modiano, Richard Letourneau, J. Ackerman, R. L. De Jager, Nerses Simon Tchekmedyian
Publikováno v:
Memorial Sloan Kettering Cancer Center
4006 BACKGROUND: DX is a novel hexacyclic, water-soluble, topoisomerase-1 inhibitor. DX has single-agent and combination activity with GEM in APC (D'Adamo, et al. ASCO, 2001; O'Reilly, et al. ASCO, 2002). A multicenter, randomized phase III trial com