Zobrazeno 1 - 10
of 39
pro vyhledávání: '"E. M. Hawes"'
Publikováno v:
Journal of Natural Products. 63:857-860
Clivorine (1) and ligularine (2), two hepatotoxic otonecine-type pyrrolizidine alkaloids isolated from Ligularia hodgsonii, an antitussive traditional Chinese medicine, were investigated in CDCl(3) and D(2)O by various NMR techniques to delineate why
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054010996ebf48d1f856d4178dc3ca49
https://doi.org/10.1021/np9906119
https://doi.org/10.1021/np9906119
Autor:
T. Van Putten, G. Mckay, K.K. Midha, Manickam Aravagiri, Stephen R. Marder, E. M. Hawes, Jim Mintz, J. W. Hubbard
Publikováno v:
British Journal of Psychiatry. 158:658-665
The levels of fluphenazine and fluphenazine sulphoxide in schizophrenic patients who were randomly assigned to receive either 5 mg or 25 mg of fluphenazine decanoate every two weeks were monitored. Patients treated with 25 mg of fluphenazine decanoat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36949b1d5a0e66c2d567a971225ae73c
https://doi.org/10.1192/bjp.158.5.658
https://doi.org/10.1192/bjp.158.5.658
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(12)
The formation of the N1-glucuronide metabolite of each nicotine enantiomer was studied in pooled human liver microsomes (n = 6). The metabolite formed from natural S(-)-nicotine was identified by comparison of the high-pressure liquid chromatography
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b003764b5a74240875782f50adafe2f5
https://pubmed.ncbi.nlm.nih.gov/11717169
https://pubmed.ncbi.nlm.nih.gov/11717169
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(10)
A series of eight 1-substituted imidazoles was investigated as model substrates for glucuronidation at an aromatic tertiary amine of polyaza heterocyclic ring systems. The human UDP-glucuronosyltransferases (UGTs) involved and substrate specificities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5a5c626231f4919b078069df88bfa35
https://pubmed.ncbi.nlm.nih.gov/11560872
https://pubmed.ncbi.nlm.nih.gov/11560872
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(12)
The metabolism of the hepatotoxic otonecine-type pyrrolizidine alkaloid (PA), clivorine, was investigated using rat liver microsomes. The metabolites dehydroretronecine (DHR), 7-glutathionyldehydroretronecine (7-GSH-DHR), 7, 9-diglutathionyldehydrore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d9e83068827b6e626e302e4bcc128f0c
https://pubmed.ncbi.nlm.nih.gov/11095586
https://pubmed.ncbi.nlm.nih.gov/11095586
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(9)
1-Phenylimidazole was investigated as a potential model substrate with respect to formation of a quaternary ammonium-linked glucuronide (N(+)-glucuronide) at an aromatic type tertiary amine. A reference sample of the potential N(+)-glucuronide metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ee67be2e71ea5b98229396674739692
https://pubmed.ncbi.nlm.nih.gov/10950841
https://pubmed.ncbi.nlm.nih.gov/10950841
Autor:
E M, Hawes
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(9)
Glucuronidation of either an aliphatic or aromatic tertiary amine group in a molecule results in a quaternary ammonium-linked glucuronide metabolite (i.e. N+-glucuronide). The development of sound information on N+-glucuronide metabolites, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f692ccd17bc27672556340b7f3347c6b
https://pubmed.ncbi.nlm.nih.gov/9733660
https://pubmed.ncbi.nlm.nih.gov/9733660
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(2)
The formation of the pyrrolic alcohol glutathione (GSH) conjugates of two different types of pyrrolizidine alkaloids (PAs), i.e. clivorine (an otonecine-type PA) and retrorsine (a retronecine-type PA), was investigated with rat microsomes in the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7261719cba4a89c75ace92e60398109f
https://pubmed.ncbi.nlm.nih.gov/9456306
https://pubmed.ncbi.nlm.nih.gov/9456306
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 25(4)
The involvement of FMO in the N-oxygenation of CLZ was investigated by use of purified FMOs and human liver microsomes that contained the mean amount of immunoreactive FMO3 relative to other human liver microsomal preparations in a liver bank. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b82d29e34d4a6c58da1bc2438a399f8e
https://pubmed.ncbi.nlm.nih.gov/9107553
https://pubmed.ncbi.nlm.nih.gov/9107553
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 14(6)
The metabolism of the piperidine-type phenothiazine antipsychotic agents thioridazine, mesoridazine and sulforidazine was studied in vitro with 10 000g liver supernatants obtained from rats and dogs. After incubations at 37°C for different time inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f510089b26050b12f363e622211087e8
https://pubmed.ncbi.nlm.nih.gov/8807548
https://pubmed.ncbi.nlm.nih.gov/8807548