Zobrazeno 1 - 10
of 10
pro vyhledávání: '"E. M. Comijn"'
Autor:
Godefridus J. Peters, E. M. Comijn, Jacqueline Cloos, Gertjan J.L. Kaspers, Gerrit Jansen, Adrian C. Jaramillo, Andries M. Bergman
Publikováno v:
Jaramillo, A C, Bergman, A M, Comijn, E M, Jansen, G, Kaspers, G J L, Cloos, J & Peters, G J 2020, ' Effect of dexamethasone on the antileukemic effect of cytarabine : role of deoxycytidine kinase ', Nucleosides, Nucleotides and Nucleic Acids, vol. 39, no. 10-12, pp. 1335-1346 . https://doi.org/10.1080/15257770.2020.1780441
Nucleosides, Nucleotides and Nucleic Acids, 39(10-12), 1335-1346. Taylor and Francis Ltd.
Nucleosides, Nucleotides and Nucleic Acids, 39(10-12), 1335-1346. Taylor and Francis Ltd.
Dexamethasone (DEX) is often used in the initial treatment of leukemia. Earlier we demonstrated that DEX decreased the activity of deoxycytidine kinase (dCK) which is essential for the activation of cytarabine (ara-C). Therefore we investigated the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1505943a04f143e141e7aa8127d95c5
https://doi.org/10.1080/15257770.2020.1780441
https://doi.org/10.1080/15257770.2020.1780441
Autor:
Godefridus J. Peters, E. M. Comijn, Herbert M. Pinedo, Gerrit Jansen, P. Noordhuis, Habte Teshale, Robert Mauritz, Ietje Kathmann
Publikováno v:
Mauritz, R, Peters, G J, Kathmann, I, Teshale, H, Noordhuis, P, Comijn, E M, Pinedo, H M & Jansen, G 2008, ' Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo ', Cancer Chemotherapy and Pharmacology, vol. 62, no. 6, pp. 937-948 . https://doi.org/10.1007/s00280-008-0683-0
Cancer Chemotherapy and Pharmacology, 62(6), 937-948. Springer Verlag
Cancer Chemotherapy and Pharmacology, 62(6), 937-948. Springer Verlag
Murine L1210 leukaemia cells expressing either the reduced folate carrier (RFC) or the membrane folate receptor (MFR) were studied in vitro and in vivo to assess the dynamics of membrane transport of two categories antifolates; folate-based inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6483bac1909ea5e50f101c4d8d3b7a
https://doi.org/10.1007/s00280-008-0683-0
https://doi.org/10.1007/s00280-008-0683-0
Autor:
C.M. Kuiper, E. M. Comijn, H.R. Hendriks, G.J. Peters, D.A. Voorn, Andries M. Bergman, Finn Myhren, Marit Liland Sandvold
Publikováno v:
Biochemical Pharmacology, 67(3), 503-11. Elsevier Inc.
Bergman, A M, Kuiper, C M, Voorn, D A, Comijn, E M, Myhren, F, Sandvold, ML, Hendriks, H R & Peters, G J 2004, ' Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinofuranosylcytosine in leukemia and solid tumor cell lines. ', Biochemical Pharmacology, vol. 67, no. 3, pp. 503-11 . https://doi.org/10.1016/j.bcp.2003.09.028
Bergman, A M, Kuiper, C M, Voorn, D A, Comijn, E M, Myhren, F, Sandvold, ML, Hendriks, H R & Peters, G J 2004, ' Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinofuranosylcytosine in leukemia and solid tumor cell lines. ', Biochemical Pharmacology, vol. 67, no. 3, pp. 503-11 . https://doi.org/10.1016/j.bcp.2003.09.028
1-beta-D-arabinofuranosylcytosine (ara-C) is a deoxycytidine analog with activity in leukemia, which requires phosphorylation by deoxycytidine kinase (dCK) to allow formation of its active phosphate 1-beta-D-arabinofuranosylcytosine triphosphate, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2793f0bf230391c084290660b63bb341
https://doi.org/10.1016/j.bcp.2003.09.028
https://doi.org/10.1016/j.bcp.2003.09.028
Autor:
E. M. Comijn, G. Giaccone, G. Veerman, W.J.F. van der Vijgh, Godefridus J. Peters, D.A. Voorn, Pieter E. Postmus, C.J.A. van Moorsel, H.M. Pinedo, Kees Smid, B Lakerveld
Publikováno v:
European Journal of Cancer. 36:2420-2429
The combination of 2',2'-difluorodeoxycytidine (gemcitabine, dFdC) and cis-diammine-dichloroplatinum(II) (cisplatin, CDDP) is increasingly applied in clinical oncology. We studied the underlying mechanisms of the in vivo schedule dependency and supra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8697ac9eed855fa2185549e08c711924
https://doi.org/10.1016/s0959-8049(00)00345-2
https://doi.org/10.1016/s0959-8049(00)00345-2
Autor:
José M. Padrón, Gertjan J.L. Kaspers, Isabelle Hubeek, C.L. van der Wilt, E. M. Comijn, G.J. Peters, R. L. Merriman
Publikováno v:
Hubeek, I, Comijn, E M, van der Wilt, C L, Merriman, R L, Padron, J M, Kaspers, G J L & Peters, G J 2008, ' CI-994 (N-acetyl-dinaline) in combination with conventional anti-cancer agents is effective against acute myeloid leukemia in vitro and in vivo ', Oncology Reports, vol. 19, no. 6, pp. 1517-1523 .
Scopus-Elsevier
Oncology Reports, 19(6), 1517-1523. Spandidos Publications
Scopus-Elsevier
Oncology Reports, 19(6), 1517-1523. Spandidos Publications
N-acetyl-dinaline (CI-994) is an investigational anti-cancer drug which inhibits histone deacetylases. We evaluated the interaction between CI-994 and conventional chemotherapeutics used in acute myeloid leukemia (AML) in a rat model for AML and Brow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb398b8b9d3fb4a2f1c0bfc8fcaf264f
https://pubmed.ncbi.nlm.nih.gov/18497959
https://pubmed.ncbi.nlm.nih.gov/18497959
Publikováno v:
Scopus-Elsevier
Oncology Reports, 18(1), 287-291. Spandidos Publications
Bijnsdorp, I V, Comijn, E M, Padron, J M, Gmeiner, W H & Peters, G J 2007, ' Mechanisms of action of FdUMP[10]: Metabolite activation and thymidylate synthase inhibition ', Oncology Reports, vol. 18, no. 1, pp. 287-291 .
Oncology Reports, 18(1), 287-291. Spandidos Publications
Bijnsdorp, I V, Comijn, E M, Padron, J M, Gmeiner, W H & Peters, G J 2007, ' Mechanisms of action of FdUMP[10]: Metabolite activation and thymidylate synthase inhibition ', Oncology Reports, vol. 18, no. 1, pp. 287-291 .
FdUMP[10] is a multimer of FdUMP, a suicide inhibitor of thymidylate synthase (TS), and was designed to bypass resistance to 5-fluorouracil (5FU). The aim of the study was to compare the effect of FdUMP[10] with 5FU and 5-fluoro-2-deoxyuridine (FUdR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e840c387a07119a0f2d63ce3a297bc
https://pubmed.ncbi.nlm.nih.gov/17549381
https://pubmed.ncbi.nlm.nih.gov/17549381
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids, 23, 1503-1506. Taylor and Francis Ltd.
Sigmond, J, Comijn, E M, Kamphuis, JAE & Peters, G J 2004, ' Combinations of 5-fluorouracil with UCN-01 or staurosporine ', Nucleosides, Nucleotides and Nucleic Acids, vol. 23, pp. 1503-1506 . https://doi.org/10.1081/NCN-200027718
Sigmond, J, Comijn, E M, Kamphuis, JAE & Peters, G J 2004, ' Combinations of 5-fluorouracil with UCN-01 or staurosporine ', Nucleosides, Nucleotides and Nucleic Acids, vol. 23, pp. 1503-1506 . https://doi.org/10.1081/NCN-200027718
The action of 5‐Fluorouracil (5‐FU) is mediated by inhibition of thymidylate synthase (TS), which is regulated by cell cycle proteins controlled by protein phosphorylation. We studied the effects of staurosporine and its analogue UCN‐01, inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae07f686d7d1207790370186abc09184
https://doi.org/10.1002/chin.200512224
https://doi.org/10.1002/chin.200512224
Publikováno v:
Anti-cancer drugs. 16(3)
Trifluorothymidine (TFT) is a fluorinated thymidine analog that after conversion to its monophosphate derivative can inhibit thymidylate synthase (TS) and be incorporated into DNA. TFT is a good substrate for thymidine phosphorylase (TP), and the com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0964b0d43f5dae8e2bf8edb54140401a
https://pubmed.ncbi.nlm.nih.gov/15711180
https://pubmed.ncbi.nlm.nih.gov/15711180
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids, 23, 1491-1494. Taylor and Francis Ltd.
Temmink, O H, Comijn, E M, Fukushima, M & Peters, G J 2004, ' Intracellular thymidylate synthose inhibition by trifluorothymidine in FM3A cells ', Nucleosides, Nucleotides and Nucleic Acids, vol. 23, pp. 1491-1494 . https://doi.org/10.1081/NCN-200027707
Temmink, O H, Comijn, E M, Fukushima, M & Peters, G J 2004, ' Intracellular thymidylate synthose inhibition by trifluorothymidine in FM3A cells ', Nucleosides, Nucleotides and Nucleic Acids, vol. 23, pp. 1491-1494 . https://doi.org/10.1081/NCN-200027707
Trifluorothymidine (TFT) can be phosphorylated by thymidine kinase (TK) to TFTMP which can inhibit thymidylate synthase (TS), resulting in depletion of thymidine nucleotides. TFT can be degraded by thymidine phosphorylase (TP) which can be inhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01dc9e17cff463b2efecbcde1e71e424
https://research.vumc.nl/en/publications/d7bb0a4b-2c98-4dd1-9c17-37a147ae23fc
https://research.vumc.nl/en/publications/d7bb0a4b-2c98-4dd1-9c17-37a147ae23fc
Autor:
K. Breistol, D.A. Voorn, Finn Myhren, Marit Liland Sandvold, Kees Smid, Øystein Fodstad, G.J. Peters, E. M. Comijn, P. Noordhuis, C.M. Kuiper, H.R. Hendriks, Andries M. Bergman
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids, 23, 1329-1333. Taylor and Francis Ltd.
Bergman, A M, Kuiper, C M, Noordhuis, P, Smid, K, Voorn, D A, Comijn, E M, Myhren, F, Sandvold, ML, Hendriks, H R, Fodstad, O, Breistol, K & Peters, G J 2004, ' Antiproliferative activity and mechanism of action of fatty acid derivatives of gemcitabine in leukemia and solid tumor cell lines and in human xenografts ', Nucleosides, Nucleotides and Nucleic Acids, vol. 23, pp. 1329-1333 . https://doi.org/10.1081/NCN-200027579
Bergman, A M, Kuiper, C M, Noordhuis, P, Smid, K, Voorn, D A, Comijn, E M, Myhren, F, Sandvold, ML, Hendriks, H R, Fodstad, O, Breistol, K & Peters, G J 2004, ' Antiproliferative activity and mechanism of action of fatty acid derivatives of gemcitabine in leukemia and solid tumor cell lines and in human xenografts ', Nucleosides, Nucleotides and Nucleic Acids, vol. 23, pp. 1329-1333 . https://doi.org/10.1081/NCN-200027579
Gemcitabine is a deoxycytidine analog, which can be inactivated by deamination catalyzed by deoxycytidine deaminase (dCDA). Altered transport over the cell membrane is a mechanism of resistance to gemcitabine. To facilitate accumulation, the fatty ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b16dbf1ab20bf1f231cf6c4fe6dedf2
https://research.vumc.nl/en/publications/9d153df8-329d-4423-bd38-bde8bf993a12
https://research.vumc.nl/en/publications/9d153df8-329d-4423-bd38-bde8bf993a12